Biology Agriculture Aquaculture Horticulture Postharvest Forestry Geography Environment Health





Muscle mass, muscle strength, functional performance,and physical impairment in women with the hypermobility type of Ehlers-Danlos syndrome

submitted by kochrchi 1 year and 10 months ago
To investigate lower extremity muscle mass, muscle strength, functional performance, and physical impairment in women with the Ehlers-Danlos Syndrome hypermobility type (EDS-HT). Forty-three women with EDS-HT and 43 sex- and age-matched healthy control subjects participated. Muscle mass was determinedby dual-energy x-ray absorptiometry. Muscle strength and muscle strength endurance weremeasured with isokinetic dynamometry at 6,18, and 24°/s angular velocities. Also static muscle endurance during posture maintenance was assessed. Simultaneously, pain and fatigue were evaluated by VAS and Borg-scale respectively. In addition, the chair rise test for assessment of functional performance and the Arthritis Impact Measurement Scale for physical impairment evaluation were used. Compared to control subjects, EDS-HT patients showed substantial lower extremity muscle weakness, reflected by significantly reduced knee extensor and flexor muscle strength and endurance parameters, with differences ranging from -3% to -49%; reduced static muscle endurance time; and diminished functional performance. Lower extremity muscle mass was similar in both groups and unlikely to affect the muscle strength results. By contrast, pain and fatigue, were omnipresent and increased remarkably due to the tests. Furthermore, the EDS-HT group was physical impaired, especially in the -domain ‘walking and bending’. This study demonstrates severely reduced quantitative muscle function and impairment in physical function in patients with EDS-HT compared to age- and sex-matched controls. The muscle weakness may be due to muscle dysfunction rather than reduced muscle mass. Whether muscle strengthand endurance can be improved by appropriate exercise programs needs evaluation in further studies.


Topic: Health

Add your comment

Please Login or Signup to leave a comment

Related stories

Relationship between fatigue and gait abnormality in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility type
submitted by diltovit 1 year and 7 months ago - Topic: Health
Ehlers-Danlos syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterised by joint hypermobility, skin hyperextensibility and tissue fragility. It has recently been shown that muscle weakness occurs frequently in EDS, and that fatigue is a common and clinically important symptom. The aim of this study was to investigate the relations...

The relationship between grip strength and muscle mass (MM), inflammatory biomarkers and physical performance in community-dwelling very old persons
submitted by ova3118 9 months ago - Topic: Health
The main consequence of the loss of MM and muscle strength is limitations of physical performance and disability in older people. It is unclear whether a decline in functional capacity results from the loss of MM and/or the qualitative impairment of the muscle tissue. The aim of our research was to investigate the relationship between physical performance and grip strength, inflammatory markers...

Physical Therapy for the Antepartum Hospitalized Patient With Ehlers-Danlos Syndrome
submitted by oyb119 5 months ago - Topic: Health
Antepartum bed rest is prescribed to minimize the risk of preterm delivery, but can lead to muscle weakness, deconditioning, musculoskeletal pain, fatigue, and depression, depending on the duration of bed rest. The purpose of this case report is to identify the physical therapist's role in treating a pregnant woman with complications of Ehlers-Danlos syndrome (EDS) who was placed on hospitalize...

Clinical Relevance of Different Muscle Strength Indexes and Functional Impairment in Women Aged 75 Years and Older
submitted by hamdastoro 1 year and 2 months ago - Topic: Health
Muscle mass index has long been used as a useful index to evaluate the risks of developing functional impairments. However, there is evidence that other indexes (particularly muscle strength–based indexes) may be more relevant. Thus, the purpose of this study was to compare the association between different indexes of muscle mass or strength with self-reported and measured functional perf...

Association of sarcopenia with functional decline in community-dwelling elderly subjects in Japan
submitted by sarish 1 year and 1 month ago - Topic: Health
The present study aimed to determine the association of sarcopenia, defined by muscle mass, muscle strength and physical performance, with functional disability from a 2-year cohort study of community-dwelling elderly Japanese people. MethodParticipants were 743 community-dwelling elderly Japanese people aged 65 years or older. We used bioelectrical impedance analysis (BIA) to measure muscle ma...

Dietary intake and physical performance in healthy elderly women: A 3-year follow-up
submitted by mockinta 1 year and 6 months ago - Topic: Health
Aging is generally accompanied by changes in body composition, muscle mass and strength, leading to a decline in motor and functional performance. Physical activity and eating habits could be involved in modulating this paraphysiological deterioration. of our study was to investigate changes in body composition, diet and physical performance in healthy, elderly females over a 3-year follow-up. ...


Association of anorexia with sarcopenia in a community-dwelling elderly population: results from the ilSIRENTE study
submitted by stivi2065 1 year and 7 months ago - Topic: Health
There is increasing evidence that anorexia of aging can cause physical and mental impairment. The aim of the present study was to evaluate the relationship between anorexia and sarcopenia in elderly persons aged 80 years or older. Data are from the baseline evaluation of 354 subjects enrolled in the ilSIRENTE study. The ilSIRENTE study is a prospective cohort study performed in the mountain com...

Bradykinin type 2 receptor -9/-9 genotype is associated with triceps brachii muscle hypertrophy following strength training in young healthy men
submitted by jpv2053 1 year and 5 months ago - Topic: Health
Bradykinin type 2 receptor (B2BRK) genotype was reported to be associated with changes in the left-ventricular mass as a response to aerobic training, as well as in the regulation of the skeletal muscle performance in both athletes and non-athletes. However, there are no reports on the effect of B2BRK 9-bp polymorphism on the response of the skeletal muscle to strength training, and our aim was...

Muscular wasting, sarcopenia and cachexia: a trouble for the patients, a challenge for the doctors. The role of the person in this dramatic scenario
submitted by somonih 1 year and 4 months ago - Topic: Health
Nowadays, the importance of muscle mass, strength, and metabolic function is demonstrated in both the daily life activities and prognosis. However, the evaluation of muscle mass is not routinely measured by doctors. Clinically, the loss of muscular mass is classified as: muscular wasting, sarcopenia, cachexia. The pathogenesis of sarcopenia-wasting-cachexia is multi-factorial. Indeed, imbalance...

Preliminary evidence that low ankle-brachial index is associated with reduced bilateral hip extensor strength and functional mobility in peripheral arterial disease
submitted by agagag 1 year and 3 months ago - Topic: Health
Peripheral arterial disease (PAD) has been associated with skeletal muscle pathology, including atrophy of the affected muscles. In addition, oxidative metabolism is impaired, muscle function is reduced, and gait and mobility are restricted. We hypothesized that greater severity of symptomatic PAD would be associated with lower levels of muscle mass, strength, and endurance, and that these musc...

Prevalence and associated factors of sarcopenia among elderly in Brazil: Findings from the SABE study
submitted by jaykowo 4 months ago - Topic: Health
The aim of the present study was to examine the prevalence and factors associated with sarcopenia in older residents in São Paulo, Brazil. Cross-sectional study. São Paulo, Brazil.1,149 older individuals from the second wave of the Saúde, Bem-Estar e Envelhecimento (SABE) study from 2006. The definition of sarcopenia was based on the consensus of the European Working Group on Sarcopenia in O...

Gender Differences in Anthropometric Predictors of Physical Performance in Older Adults
submitted by daomortenizpo 1 year and 5 months ago - Topic: Health
Both high body fat and low muscle mass have been associated with physical disability in older adults. However, men and women differ markedly in body composition; men generally have more absolute and relative lean muscle mass and less fat mass than women. It is not known how these anthropometric differences differentially affect physical ability in men and women. This study examines differences ...