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Muscle mass, muscle strength, functional performance,and physical impairment in women with the hypermobility type of Ehlers-Danlos syndrome

submitted by kochrchi 1 year and 10 months ago
To investigate lower extremity muscle mass, muscle strength, functional performance, and physical impairment in women with the Ehlers-Danlos Syndrome hypermobility type (EDS-HT). Forty-three women with EDS-HT and 43 sex- and age-matched healthy control subjects participated. Muscle mass was determinedby dual-energy x-ray absorptiometry. Muscle strength and muscle strength endurance weremeasured with isokinetic dynamometry at 6,18, and 24°/s angular velocities. Also static muscle endurance during posture maintenance was assessed. Simultaneously, pain and fatigue were evaluated by VAS and Borg-scale respectively. In addition, the chair rise test for assessment of functional performance and the Arthritis Impact Measurement Scale for physical impairment evaluation were used. Compared to control subjects, EDS-HT patients showed substantial lower extremity muscle weakness, reflected by significantly reduced knee extensor and flexor muscle strength and endurance parameters, with differences ranging from -3% to -49%; reduced static muscle endurance time; and diminished functional performance. Lower extremity muscle mass was similar in both groups and unlikely to affect the muscle strength results. By contrast, pain and fatigue, were omnipresent and increased remarkably due to the tests. Furthermore, the EDS-HT group was physical impaired, especially in the -domain ‘walking and bending’. This study demonstrates severely reduced quantitative muscle function and impairment in physical function in patients with EDS-HT compared to age- and sex-matched controls. The muscle weakness may be due to muscle dysfunction rather than reduced muscle mass. Whether muscle strengthand endurance can be improved by appropriate exercise programs needs evaluation in further studies.

Topic: Health

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