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Risk factors for peristomal pyoderma gangrenosum complicating inflammatory bowel disease

submitted by samonothco 1 year and 10 months ago
Risk factors for peristomal pyoderma gangrenosum (PPG) are not well defined. The aim of this study was to evaluate risk factors associated with development of PPG. Both PPG patients and controls were obtained by searching a database of the Cleveland Clinic using the ICD-9 code from March 2005 to May 201The control group was selected by matching for underlying diseases and type of stoma in a ratio of 3:Univariate and multivariate analyses were performed. A total of 15 PPG cases and 45 controls were included. The mean age at the time of PPG diagnosis was 46.0±14.4years. The underlying disease was Crohn's disease in 7 patients (46.7%), ulcerative colitis in 7 (46.7%) and indeterminate colitis in 1 (6.7%). Eleven patients (73.3%) had end ileostomy, 3 (20.0%) had loop ileostomy and 1 (6.7%) had colostomy. Eleven patients (73.3%) had active intestinal disease. In multivariate analysis, female gender, the presence of concurrent autoimmune disorders, and a high body mass index (BMI) were significantly associated with the presence of PPG, with odds ratios of 8.385 (95% confidence interval [CI]: 1.496–46.982, p=0.015), 6.882 (95% CI:1.438–32.941, p=0.016), and 9.895 (95% CI: 1.970–43.704, p=0.005), respectively. After a median follow-up of 12.8 (interquartile range: 7.9–20.1) months with appropriate therapy, PPG healed in 8 patients (53.3%) and improved in 7 (46.7%) patients, after treatment. Female gender, the presence of autoimmune disorders and a high BMI appeared to be associated with an increased risk for the development of PPG in IBD patients.

Topic: Health

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