Biology Agriculture Aquaculture Horticulture Postharvest Forestry Geography Environment Health

Recent Advances in Receptor-Targeted Fluorescent Probes for In Vivo Cancer Imaging

submitted by morji 1 year and 6 months ago
Receptor-targeted optical imaging of cancer is emerging as an attractive strategy for early cancer diagnosis and surgical guidance. The success of such strategy depends largely upon the development of receptor-targeted fluorescent probes with high specificity and binding affinity to the target receptors. Recently, a host of such probes have been reported to target cancer-specific receptors, such as somatostatin receptors (SSTRs), integrin receptors, cholecystokinin-2 (CCK2) receptor, gastrin-releasing peptide (GRP) receptor, endothelin A (ETA) receptor, translocator protein (TSPO) receptor, epidermal growth factor (EGF) receptor, human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF) receptor, folate receptor (FR), transferrin receptor (TFR), low-density lipoprotein (LDL) receptors, type I insulin-like growth factor receptor (IGF1R), vasoactive intestinal peptide (VIP) receptors, urokinase plasminogen activator (uPA) and estrogen receptor (ER). This review will describe the recent advances in synthetic targeting optical imaging probes and demonstrate their in vivo imaging potentials. Moreover, current status of near infrared (NIR) fluorescent dyes, targeting moieties and coupling reactions, as well as strategies for designing targeted probes, will also be discussed.

Topic: Health

Add your comment

Please Login or Signup to leave a comment

Related stories

RGD-based PET tracers for imaging receptor integrin αvβ3 expression
submitted by rodasistros 1 year and 2 months ago - Topic: Health
Positron emission tomography (PET) imaging of receptor integrin αvβ3 expression may play a key role in the early detection of cancer and cardiovascular diseases, monitoring disease progression, evaluating therapeutic response, and aiding anti-angiogenic drugs discovery and development. The last decade has seen the development of new PET tracers for in vivo imaging of integrin αvβ3 expressio...

The σ2 Receptor: A Novel Protein for the Imaging and Treatment of Cancer
submitted by miow 10 months ago - Topic: Agriculture
The σ2 receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells compared with that in quiescent tumor cells and because of the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic and nonapoptotic mechanisms. Although recent evidence indicates that the σ2 receptor binding...

Imaging early signaling events in T lymphocytes with fluorescent biosensors
submitted by amor 5 months ago - Topic: Biology
Many recent advances in our understanding of T lymphocyte functions in adaptive immunity are derived from sophisticated imaging techniques used to visualize T lymphocyte behavior in vitro and in vivo. A current challenge is to couple such imaging techniques with methods that will allow researchers to visualize signaling phenomenon at the single-cell level. Fluorescent biosensors, either synthet...

Near Infrared Receptor-Targeted Nanoprobes for Early Diagnosis of Cancers
submitted by stippigald 1 year and 6 months ago - Topic: Health
The success of detecting cancer at early stages relies greatly on the sensitivity and specificity of in vivo molecular imaging. Optical imaging with near infrared (NIR) luminescent molecular nanoprobes currently attracts much attention because of many advantages of this imaging modality. It provides real time imaging with relatively inexpensive cost, produces images with high sensitivity and sp...

Recent Advances in Optical Cancer Imaging of EGF Receptors
submitted by ijo 1 year and 6 months ago - Topic: Health
Epidermal growth factor (EGF) receptors are commonly expressed on the cell membrane of cancer cells and activity of these receptors results in accelerated cell growth and carcinogenesis. A variety of targeted molecules have been developed to block ligand binding and/or inhibit the function of these receptor tyrosine kinases, and several have proven therapeutic benefits. Along with the advent of...

MRI reporter genes: applications for imaging of cell survival, proliferation, migration and differentiation
submitted by mnasawetz 1 year and 4 months ago - Topic: Health
Molecular imaging strives to detect molecular events at the level of the whole organism. In some cases, the molecule of interest can be detected either directly or with targeted contrast media. However many genes and proteins and particularly those located in intracellular compartments are not accessible for targeted agents. The transcriptional regulation of these genes can nevertheless be dete...

Molecular Imaging of Very Late Antigen-4 (alpha4beta1 Integrin) in the Premetastatic Niche
submitted by preyonkore3115 1 year and 11 months ago - Topic: Health
Despite advances in cancer treatment over the past few decades, metastatic disease remains the primary cause of morbidity and mortality. Recent reports suggest the formation of a "premetastatic niche" before the metastatic cascade, where niche is defined as the microenvironment for tumor cells to be able to engraft and proliferate at secondary sites. Bone marrow–derived (BMD) cells that e...

Miniprobe endoscopic ultrasound accurately stages esophageal cancer and guides therapeutic decisions in the era of neoadjuvant therapy: results of a multicenter cohort analysis
submitted by eaono2095 1 year and 2 months ago - Topic: Health
Despite recent advances in imaging techniques, adequate classification of esophageal lesions is still challenging. Accurate staging of tumors of the esophagus is a precondition for targeted therapy. In this retrospective, multicenter study, we report the role of high-frequency endoscopic ultrasound (EUS) catheter probes in pretherapeutic staging of esophageal neoplasms and thus guiding treatmen...

Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target: potential clinical applications
submitted by dena 1 year and 1 month ago - Topic: Biology
Urokinase-type plasminogen activator receptor (uPAR) has been shown to be of special importance during cancer invasion and metastasis. However, currently, tissue samples are needed for measurement of uPAR expression limiting the potential as a clinical routine. Therefore, non-invasive methods are needed. In line with this, uPAR has recently been identified as a very promising imaging target can...

New directions in quantum dot-based cytometry detection of cancer serum markers and tumor cells
submitted by reatardella 1 year and 6 months ago - Topic: Health
The use of fluorescent quantum dots (QDs) incorporated in or tagged with polymeric microbeads allows multiplexed coding of biomolecules. Compared to organic dyes, QDs are characterized by improved imaging capabilities, brightness, and photostability and may be used for simultaneous detection of multiple biomarkers. Development of QD conjugates and QD-encoded suspension arrays has given rise to ...

Intragenic integration in DLC1 sustains factor VIII expression in primary human cells without insertional oncogenicity
submitted by brejsdi 2 months ago - Topic: Biology
Techniques enabling precise genome modifications enhance the safety of gene-based therapy. DLC1 is a hot spot for phiC31 integrase-mediated transgene integration in vitro and in vivo. Here we show that integration of a coagulation factor VIII transgene into intron 7 of DLC1 supports durable expression of factor VIII in primary human umbilical cord-lining epithelial cells. Oligoclonal cells with...