Biology Agriculture Aquaculture Horticulture Postharvest Forestry Geography Environment Health





A pilot study of alternative transcranial direct current stimulation electrode montages for the treatment of major depression

submitted by tenyoni 20 days ago
Typically, transcranial direct current stimulation (tDCS) treatments for depression have used bifrontal montages with anodal (excitatory) stimulation targeting the left dorsolateral prefrontal cortex (DLPFC). There is limited research examining the effects of alternative electrode montages. This pilot study aimed to examine the feasibility, tolerability and safety of two alternative electrode montages and provide preliminary data on efficacy. The montages, Fronto-Occipital (F-O) and Fronto-Cerebellar (F-C), were designed respectively to target midline brain structures and the cerebellum. The anode was placed over the left supraorbital region and the cathode over the occipital and cerebellar region for the F-O and F-C montages respectively. Computational modelling was used to determine the electric fields produced in the brain regions of interest compared to a standard bifrontal montage. The two montages were evaluated in an open label study of depressed participants (N=14). Mood and neuropsychological functioning were assessed at baseline and after four weeks of tDCS. Computational modelling revealed that the novel montages resulted in greater activation in the anterior cingulate cortices and cerebellum than the bifrontal montage, while activation of the DLPFCs was higher for the bifrontal montage. After four weeks of tDCS, overall mood improvement rates of 43.8% and 15.9% were observed under the F-O and F-C conditions, respectively. No significant neuropsychological changes were found. The clinical pilot was open-label, without a control condition and computational modelling was based on one healthy participant. Results found both montages safe and feasible. The F-O montage showed promising antidepressant potential.


Topic: Health

Add your comment

Please Login or Signup to leave a comment

Related stories

Developing Patient-Centered Treatment Protocols in Brain Stimulation: A Rationale for Combining Quantitative and Qualitative Approaches in Persons With HIV
submitted by ile319 2 years and 1 month ago - Topic: Health
This article reports and discusses how quantitative (physiological and behavioral) and qualitative methods are being combined in an open-label pilot feasibility study. The study evaluates safety, tolerability, and acceptability of a protocol to treat depression in HIV-infected individuals, using a 2-week block of transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal co...

Concurrent cognitive control training augments the antidepressant efficacy of tDCS. A pilot study
submitted by dramor 7 months ago - Topic: Health
Major depressive disorder (MDD) is frequently associated with under activity of the dorsolateral prefrontal cortex (DLPFC) which has led to this brain region being identified as an important target for the development of neurobiological treatments. Transcranial direct current stimulation (tDCS) administered to the DLPFC has antidepressant efficacy, however the magnitude of antidepressant outcom...



A computational modelling study of transcranial direct current stimulation montages used in depression
submitted by jadeth 6 months ago - Topic: Health
Transcranial direct current stimulation (tDCS) is a neuromodulatory technique which involves passing a mild electric current to the brain through electrodes placed on the scalp. Several clinical studies suggest that tDCS may have clinically meaningful efficacy in the treatment of depression. The objective of this study was to simulate and compare the effects of several tDCS montages either used...

Targeted transcranial direct current stimulation for rehabilitation after stroke
submitted by rodasistros 1 year and 3 months ago - Topic: Health
Transcranial direct current stimulation (tDCS) is being investigated as an adjunctive technique to behavioral rehabilitation treatment after stroke. The conventional “dosage”, consisting of a large (25cm2) anode over the target with the cathode over the contralateral hemisphere, has been previously shown to yield broadly distributed electric fields whose intensities at the target region are...


Continuation transcranial direct current stimulation for the prevention of relapse in major depression
submitted by vencieadeco 1 year and 7 months ago - Topic: Health
Transcranial direct current stimulation (tDCS) is gaining attention as an effective new treatment for major depression. Little is known, however, of the duration of antidepressant effects following acute treatment. In this study, we describe the use of continuation tDCS treatment for up to 6 months following clinical response to an acute treatment course. Twenty-six participants pooled from two...

Transcranial direct current stimulation for the outpatient treatment of poor-responder depressed patients
submitted by mapor46 1 year and 10 months ago - Topic: Health
Transcranial direct current stimulation (tDCS) is a selective, painless, brain stimulation technique that allows the electric stimulation of specific cortical regions. TDCS has been recently used as investigational intervention for major depression and treatment resistant depression (TRD) with encouraging results. The present study was aimed to investigate the efficacy and tolerability of tDCS ...


Interactions between transcranial direct current stimulation (tDCS) and pharmacological interventions in the Major Depressive Episode: Findings from a naturalistic study
submitted by osh3111 1 year and 7 months ago - Topic: Health
Transcranial direct current stimulation (tDCS) is a non-invasive, neuromodulatory technique with an emerging role for treating major depression. To investigate the interactions between tDCS and drug therapy in unipolar and bipolar depressed patients who were refractory for at least one pharmacological treatment. This was a naturalistic study using data from 54 female and 28 male patients (mean ...

The sertraline versus electrical current therapy for treating depression clinical study (select-tdcs): results of the crossover and follow-up phases
submitted by jisascall 1 year and 2 months ago - Topic: Health
Transcranial direct current stimulation (tDCS) is a promising nonpharmacological therapy for major depression. In the Sertraline versus Electrical Current Therapy for Treating Depression Clinical Trial (SELECT-TDCS) trial, phase-I (Brunoni et al., JAMA Psychiatry, 2013) we found that tDCS is effective for the acute episode. Here, we describe tDCS effects during phases II (crossover) and III (fo...


Therapeutic DNA Vaccination Using In Vivo Electroporation Followed by Standard of Care Therapy in Patients With Genotype 1 Chronic Hepatitis C
submitted by rechisib 1 year and 1 month ago - Topic: Health
Clearance of infections caused by the hepatitis C virus (HCV) correlates with HCV-specific T cell function. We therefore evaluated therapeutic vaccination in 12 patients with chronic HCV infection. Eight patients also underwent a subsequent standard-of-care (SOC) therapy with pegylated interferon (IFN) and ribavirin. The phase I/IIa clinical trial was performed in treatment naive HCV genotype 1...

Comparable seizure characteristics in magnetic seizure therapy and electroconvulsive therapy for major depression
submitted by obdole3113 1 year and 1 month ago - Topic: Health
Electroconvulsive therapy (ECT) is highly effective for treatment-resistant depression (TRD); however, its use for less severe forms of depression is somewhat limited by a lack of control over current spreading to medial temporal lobe memory structures, resulting in various cognitive side effects. In contrast, magnetic seizure therapy (MST), which uses high frequency repetitive transcranial mag...