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Biology

Human prion diseases and the risk of their transmission during anatomical dissection
submitted by 1 hour ago - Topic: Biology
Prion diseases (or transmissible spongiform encephalopathies) are a unique group of fatal progressive neurodegenerative diseases of the central nervous system. The infectious agent is hypothesized to consist solely of a highly protease-resistant misfolded isoform of the host prion protein. Prions display a remarkable degree of resistance to chemical and physical decontamination. Many common for...



The Role of Genetic Counselors for Patients with Familial Hypercholesterolemia
submitted by 1 hour ago - Topic: Biology
Familial hypercholesterolemia (FH) is the most common inherited cause of premature coronary heart disease and leads to significant morbidity and mortality. Genetic counselors are specialized health care professionals with advanced degrees and training in both medical genetics and psychosocial counseling. FH patients and their families require focused education regarding the heritable nature of ...

Genetic Counseling for Diabetes Mellitus
submitted by 1 hour ago - Topic: Biology
Most diabetes is polygenic in etiology, with (type 1 diabetes, T1DM) or without (type 2 diabetes, T2DM) an autoimmune basis. Genetic counseling for diabetes generally focuses on providing empiric risk information based on family history and/or the effects of maternal hyperglycemia on pregnancy outcome. An estimated one to five percent of diabetes is monogenic in nature, e.g., maturity onset dia...

Complete genome sequence of the phaeobacter gallaeciensis type strain cip 105210t (= dsm 26640t = bs107t)
submitted by 1 hour ago - Topic: Biology
Phaeobacter gallaeciensis CIP 105210T (= DSM 26640T = BS107T) is the type strain of the species Phaeobacter gallaeciensis. The genus Phaeobacter belongs to the marine Roseobacter clade (Rhodobacteraceae, Alphaproteobacteria). Phaeobacter species are effective colonizers of marine surfaces, including frequent associations with eukaryotes. Strain BS107T was isolated from a rearing of the scallop ...

Genome sequence of the pink to light reddish-pigmented Rubellimicrobium mesophilum type strain (DSM 19309T), a representative of the Roseobacter clade isolated from soil, and emended description of the species
submitted by 1 hour ago - Topic: Biology
Rubellimicrobium mesophilum Dastager et al. 2008 is a mesophilic and light reddish-pigmented representative of the Roseobacter clade within the alphaproteobacterial family Rhodobacteraceae Representatives of the Roseobacter clade play an important role in the marine biogeochemical cycles and were found in a broad variety of marine environments associated to algae blooms, different kinds of sedi...



Trends of isolation of intrinsically resistant to colistin Enterobacteriaceae and association with colistin use in a tertiary hospital
submitted by 1 hour ago - Topic: Biology
The objective of this investigation was to evaluate the association between colistin consumption and the isolation of intrinsically resistant to colistin Enterobacteriaceae (IRCE) in a university hospital in Crete, Greece. The database of the microbiological laboratory was reviewed retrospectively during 2006–2010. All positive cultures for IRCE were retrieved. We assessed the total consumpti...

MPGraph: multi-view penalised graph clustering for predicting drug-target interactions
submitted by 2 hours ago - Topic: Biology
Identifying drug-target interactions has been a key step for drug repositioning, drug discovery and drug design. Since it is expensive to determine the interactions experimentally, computational methods are needed for predicting interactions. In this work, the authors first propose a single-view penalised graph (SPGraph) clustering approach to integrate drug structure and protein sequence data ...


In silico identification of potential targets and drugs for non-small cell lung cancer
submitted by 2 hours ago - Topic: Biology
Lung cancer is one of the leading causes of death in both the USA and Taiwan, and it is thought that the cause of cancer could be because of the gain of function of an oncoprotein or the loss of function of a tumour suppressor protein. Consequently, these proteins are potential targets for drugs. In this study, differentially expressed genes are identified, via an expression dataset generated f...

Inferring non-synonymous single-nucleotide polymorphisms-disease associations via integration of multiple similarity networks
submitted by 2 hours ago - Topic: Biology
Detecting associations between human genetic variants and their phenotypic effects is a significant problem in understanding genetic bases of human-inherited diseases. The focus is on a typical type of genetic variants called nonsynonymous single nucleotide polymorphisms (nsSNPs), whose occurrence may potentially alter the structures of proteins, affecting functions of proteins, and thereby cau...


Degree-adjusted algorithm for prioritisation of candidate disease genes from gene expression and protein interactome
submitted by 2 hours ago - Topic: Biology
Computational methods play an important role in the disease genes prioritisation by integrating many kinds of data sources such as gene expression, functional annotations and protein-protein interactions. However, the existing methods usually perform well in predicting highly linked genes, whereas they work quite poorly for loosely linked genes. Motivated by this observation, a degree-adjusted ...

Comprehensive study of tumour single nucleotide polymorphism array data reveals significant driver aberrations and disrupted signalling pathways in human hepatocellular cancer
submitted by 2 hours ago - Topic: Biology
The authors describe an integrated method for analysing cancer driver aberrations and disrupted pathways by using tumour single nucleotide polymorphism (SNP) arrays. The authors new method adopts a novel statistical model to explicitly quantify the SNP signals, and therefore infers the genomic aberrations, including copy number alteration and loss of heterozygosity. Examination on the dilution ...


Identification of a strawberry flavor gene candidate using an integrated genetic-genomic-analytical chemistry approach
submitted by 2 hours ago - Topic: Biology
There is interest in improving the flavor of commercial strawberry (Fragaria × ananassa) varieties. Fruit flavor is shaped by combinations of sugars, acids and volatile compounds. Many efforts seek to use genomics-based strategies to identify genes controlling flavor, and then designing durable molecular markers to follow these genes in breeding populations. In this report, fruit from two ...

Osteocytes Produce Interferon-beta
submitted by 2 hours ago - Topic: Biology
Osteoclastogenesis is controlled by osteocytes; osteocytic osteoclastogenesis regulatory molecules are largely unknown. We searched for such factors using newly developed culture methods. Our culture system mimics the three-dimensional cellular structure of bone, consisting of collagen gel-embedded osteocytic MLO-Y4 cells, stromal ST2 cells on the gel as bone lining cells, and bone marrow cells...

HC Activates Endothelial PDE4A Inhibiting Sickle RBC Adhesion
submitted by 2 hours ago - Topic: Biology
Vaso-occlusive crises are the main acute complication in sickle cell disease. They are initiated by abnormal adhesion of circulating blood cells to vascular endothelium of the microcirculation. Several interactions involving an intricate network of adhesion molecules have been described between sickle red blood cells and the endothelial vascular wall. We have shown previously that young sickle ...

Blockade of Fas Signaling Inhibits Breast Cancer Progression
submitted by 2 hours ago - Topic: Biology
Mechanisms for cancer-related inflammation remain to be fully elucidated. Non-apoptotic functions of Fas signaling have been proposed to play an important role in promoting tumor progression. It has yet to be determined if targeting Fas signaling can control tumor progression through suppression of cancer-related inflammation. In the current study we found that breast cancer cells with constitu...



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