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Representativeness-based sampling network design for the State of Alaska
submitted by otteke 2 minutes ago - Topic: Biology
AbstractResource and logistical constraints limit the frequency and extent of environmental observations, particularly in the Arctic, necessitating the development of a systematic sampling strategy to maximize coverage and objectively represent environmental variability at desired scales. A quant...



Suicidal Ideation and School Bullying Experiences After Controlling for Depression and Delinquency
submitted by bgapenoth 3 minutes ago - Topic: Health
This cross-sectional study examines differences in the frequency of suicidal ideation and suicidal behaviors across a group of verbal bullies, bully-victims, victims, physically aggressive bullies, and students not involved in bullying. A large sample of middle school students (n = 661; fifth th...

Potential Suicide Ideation and Its Association With Observing Bullying at School
submitted by bgapenoth 3 minutes ago - Topic: Health
To explore those contextual factors that predict potential suicide ideation among students who observe bullying at school. 1,592 students of whom 1,009 who reported having observed bullying at school were surveyed from 14 secondary schools in the North of England. Role-related (not-involved, vict...

Suicidal Adolescents’ Experiences With Bullying Perpetration and Victimization during High School as Risk Factors for Later Depression and Suicidality
submitted by bgapenoth 3 minutes ago - Topic: Health
This is the first study to examine the extent to which frequent involvement in high-school bullying (as a bullying perpetrator, victim of bullying, or bully-victim) increases the risk for later depression and suicidality beyond other well-established risk factors of suicide. The study included 96...

Acutely Suicidal Adolescents Who Engage in Bullying Behavior: 1-Year Trajectories
submitted by bgapenoth 3 minutes ago - Topic: Health
Prospective longitudinal research is needed to examine associations between bullying behaviors and trajectories of suicidal ideation and behavior and overall functional impairment. The specific aims of the present study are to: (1) characterize differences in baseline functioning between acutely ...



Suicidal Thinking and Behavior Among Youth Involved in Verbal and Social Bullying: Risk and Protective Factors
submitted by bgapenoth 3 minutes ago - Topic: Health
To identify risk and protective factors associated with thinking about or attempting suicide among youth involved in verbal and social bullying. We analyzed data on 130,908 students in the sixth, ninth, and twelfth grades responding to the 2010 Minnesota Student Survey. Among students involved in...

Efficacy and safety of canagliflozin in Japanese patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, 12-week study
submitted by jeddocattan 4 minutes ago - Topic: Health
We examined the efficacy, safety and tolerability of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in Japanese patients with type 2 diabetes (T2DM) undergoing diet and exercise therapy. aged 20–80 years with T2DM diagnosed ≥3 months previously, and HbA1c of 6.9–9.9% were rando...

Olanzapine increases hepatic glucose production through the activation of hypothalamic AMPK
submitted by jeddocattan 4 minutes ago - Topic: Health
To investigate the mechanism of the metabolic disturbance induced by the atypical antipsychotic olanzapine, we examined whether adenosine 5’-monophosphate-activated protein kinase (AMPK) in the hypothalamus and hepatic glucose production are involved in the effect of olanzapine. Male 6-week-old...

The Cannabinoid Receptor 1 and its role in influencing peripheral metabolism
submitted by jeddocattan 4 minutes ago - Topic: Health
Evidence from in vitro and in vivo studies have demonstrated the deleterious pathological effects of a dysregulated endocannabinoid system. Increased stimulation of the cannabinoid receptor 1 (CB1) and subsequent downstream cellular signalling, are both causative in the deleterious pathological e...

Sitagliptin and pioglitazone provide complementary effects on postprandial glucose and pancreatic islet cell function
submitted by jeddocattan 4 minutes ago - Topic: Health
The effects of sitagliptin and pioglitazone, alone and in combination, on α- and β-cell function were assessed in patients with type 2 diabetes. Following a 6-week diet/exercise period, 211 patients with HbA1c of 6.5-9.0% and fasting plasma glucose of 7.2-14.4 mmol/L were randomized (1:1:1:1) t...

A propensity score matched comparison of different insulin regimens 1 year after beginning insulin in people with type 2 diabetes
submitted by jeddocattan 4 minutes ago - Topic: Health
To compare using propensity score analysis the outcome of beginning insulin therapy with basal, premix, meal-time + basal or meal-time insulin using data from 3031 people from the observational CREDIT (Cardiovascular Risk Evaluation in people with Type 2 Diabetes on Insulin Therapy) study. Th...

Using curriculum-based measurement to examine summer learning loss
submitted by geriishkoyyar 7 minutes ago - Topic: Health
Summer loss of reading is a potential factor in maintaining, and potentially widening, the achievement gap. This study used curriculum-based measurement of reading (R-CBM) to investigate the effect of the summer on reading. For this study, 317 students in Grades 2 to 5 were assessed in the spring...

Measuring aspirations, belonging, and productivity in secondary students: validation of the student school engagement measure
submitted by geriishkoyyar 7 minutes ago - Topic: Health
This article proposes a model of student school engagement, comprising aspirations, belonging, and productivity. From this model, items for the Student School Engagement Measure (SSEM) were developed. The SSEM was validated with data from 396 eighth graders in an urban school district. Utilizing ...

Behavioral intention of teachers, school psychologists, and counselors to intervene and prevent harassment of lgbtq youth
submitted by geriishkoyyar 7 minutes ago - Topic: Health
A national sample of educators were surveyed to identity the attitudes, beliefs, school culture, and perceived barriers that would predict whether educators would intervene to stop bias and harassment directed at lesbian, gay, bisexual, transgendered, and questioning (LGBTQ) youth in schools. The...

Ube3a/E6AP is involved in a subset of MeCP2 functions
submitted by orreboso 8 minutes ago - Topic: Biology
Rett syndrome (R) and Angelman syndrome (AS) are devastating neurological disorders that share many clinical features. The disease-causing mutations have been identified for both syndromes. Mutations in Methyl-CpG Binding Protein 2 (MECP2) are found in a majority of patients with classical R whil...