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Identification of fibronectin binding sites in dermatopontin and their biological function
submitted by dalsapan 52 minutes ago - Topic: Health
Dermatopontin (DP) is a 22kDa acidic extracellular matrix (ECM) protein that plays a critical role in both ECM structure and wound healing. Previously, we demonstrated that DP interacts with fibronectin (Fn) and promotes formation of insoluble Fn fibrils that are called activated Fn (Kato, et al., J Biol Chem 286:14861–14869, 2011). Details of the interaction between DP and Fn are investigate...



Characterisation of the faecal metabolome and microbiome of Thoroughbred racehorses
submitted by stippigald 1 hour ago - Topic: Agriculture
The intestinal bacterial community of the horse is a key determinant of intestinal and whole-body health. Understanding the bacterial community structure and function is an important foundation for studies of intestinal health and disease. To describe the faecal bacterial community and the volatile organic compounds (VOCs) of the faecal metabolome of healthy Thoroughbred racehorses, and to char...

Challenges of Governing Second-Growth Forests: A Case Study from the Brazilian Amazonian State of Para
submitted by menaa112 1 hour ago - Topic: Forestry
Despite the growing ecological and social importance of second-growth and regenerating forests across much of the world, significant inconsistencies remain in the legal framework governing these forests in many tropical countries and elsewhere. Such inconsistencies and uncertainties undermine attempts to improve both the transparency and sustainability of management regimes. Here, we present a ...

Intracellular lipid accumulation and shift during diabetes progression
submitted by dittja 1 hour ago - Topic: Health
In past decades, type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease developed into a global public health disease with an endemic scale. Although up to now the pathogenesis of T2DM is still poorly understood, ectopic lipid accumulation is one of the strongest predictors for T2DM and is closely associated with insulin resistance. This review aims (i) to overview recent literatu...

The efficacy of oxygen wafting using different delivery devices, flow rates and device positioning
submitted by morji 1 hour ago - Topic: Health
Oxygen “wafting” provides a non-contact oxygen alternative for uncooperative paediatric patients in the emergency department (ED). The aim of this study was to identify the combination of oxygen delivery device, flow rate and device positioning that delivers the highest concentration of wafted oxygen. ED nursing staff were surveyed to determine current oxygen wafting practice. A simulated p...



Preparation of 99mTc carbonyl DTPA-bevacizumab and its bioevaluation in a melanoma model
submitted by gmahommody 1 hour ago - Topic: Health
The objective of this study was to explore the potential of 99mTc carbonyl labeled DTPA-bevacizumab as a tumor imaging agent. Bevacizumab (Avastin) is a humanized monoclonal antibody (MoAb) that inhibits the vascular endothelial growth factor (VEGF). Bevacizumab was conjugated with paraisothiocyanatobenzyl diethylenetriamine pentaacetic acid (p-SCN-Bn-DTPA) and subsequently radiolabeled with 99...

Quantification of myocardial blood flow using 201Tl SPECT and population-based input function
submitted by gmahommody 1 hour ago - Topic: Health
Thallium-201 (201Tl) single photon emission computed tomography (SPECT) is an important tool in the diagnosis of ischemic heart disease. Absolute quantification of myocardial blood flow (MBF) has the potential to provide more useful information on myocardial perfusion than semi-quantitative assessments. This study aimed to validate the quantification of MBF using 201Tl cardiac SPECT based on a ...


Use of 99mTc-anti-TNF-α scintigraphy in a patient with non-radiographic axial spondyloarthritis
submitted by gmahommody 1 hour ago - Topic: Health
The aim of this study was to describe the use of 99mTc-anti-TNF-α scintigraphy for detecting inflammation of the sacroiliac joints in a patient with non-radiographic axial spondyloarthritis. A 47-year-old female patient, non-smoker and non-drinker, complained of a low back pain inflammation, which began 4 years before her condition have exacerbated to morning stiffness and anterior uveitis in...

Lean forward: Genetic analysis of temperature-sensitive mutants unfolds the secrets of oligomeric protein complex assembly
submitted by trichas3111 1 hour ago - Topic: Biology
Multisubunit protein complexes are essential for cellular function. Genetic analysis of essential processes requires special tools, among which temperature-sensitive (Ts) mutants have historically been crucial. Many researchers assume that the effect of temperature on such mutants is to drive their proteolytic destruction. In fact, degradation-mediated elimination of mutant proteins likely expl...


Centipeda periodontii in human periodontitis
submitted by mvonzannivild 2 hours ago - Topic: Health
This study assessed the subgingival occurrence of the flagellated, Gram-negative, anaerobic rod Centipeda periodontii in chronic periodontitis and periodontal health/gingivitis with species-specific nucleic acid probes, and evaluated the in vitro resistance of subgingival isolates to therapeutic levels of amoxicillin, metronidazole, and doxycycline. Subgingival plaque biofilm specimens from 307...

Roles of cathelicidins in inflammation and bone loss
submitted by mvonzannivild 2 hours ago - Topic: Health
Body surface tissues, such as the oral cavity, contact directly with the external environment and are continuously exposed to microbial insults. Cathelicidins are a family of antimicrobial peptides that are found in mammalian species. Humans and mice have only one cathelicidin. Cathelicidins are expressed in a variety of surface tissues. In addition, they are abundantly expressed in bone and bo...


Creating Successful Vernal Pools: A Literature Review and Advice for Practitioners
submitted by bibi 2 hours ago - Topic: Biology
Vernal pools provide critical breeding habitat for amphibians adapted to temporary waters, but they seldom receive the same level of protection as permanent wetlands. In response to continued degradation and loss of pools, managers often attempt to mitigate losses through pool creation or restoration. However, mitigation efforts often fail to provide suitable aquatic habitat for vernal pool amp...

Factors Affecting the Distribution Patterns of Benthic Invertebrates at a Major Shorebird Staging Site in the Yellow Sea, China
submitted by bibi 2 hours ago - Topic: Biology
The tidal flats of the Yellow Sea support benthic communities that are vitally important to migratory birds, but baseline information on benthic community structure and variability is largely lacking. We investigated spatial and temporal patterns of macrobenthic invertebrates in areas used by large numbers of shorebirds and how these patterns related to environmental factors at Yalu Jiang coast...

Study on the Quantification of Drought in Freshwater Wetlands——A Case Study in Baiyangdian Wetland
submitted by bibi 2 hours ago - Topic: Biology
Drought index is an important tool for monitoring and evaluation. A new drought index for freshwater wetlands is developed based on water balance, then used to evaluate drought in Baiyangdian Wetland (BW). Choosing the high resolution data——daily water stage (if not available, choose monthly data alternatively) as input data to compute the Wetland Drought Index (WDI). The results may be pre...

Phosphate Release Upon Long- and Short -Term Flooding of Fen Meadows Depends on Land Use History and Soil pH
submitted by bibi 2 hours ago - Topic: Biology
Flooding of acidified and desiccated fen meadows is a management approach for mitigating loss of plant species as well as a short-term measure to prevent flooding in urban areas. Studies have shown that flooding events can cause extreme P release from soils. We questioned whether the occurrence of this ‘internal eutrophication’ from flooding depended on fertilization history and soil pH. A ...