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An extract of Irish potatoes (Solanum tuberosum L.) decreases body weight gain and adiposity and improves glucose control in the mouse model of diet-induced obesity
submitted by ogplont 8 minutes ago - Topic: Health
Both sexes of mice were fed a high fat diet (HFD) for 10 wk without and with polyphenolic-rich potato extracts (PRPE) of cultivars Onaway and Russet Burbank. PRPE attenuated weight gain in male and female mice by as much as 63.2%, which was associated mostly with a reduction in adiposity. Mice receiving PRPE showed enhanced capacity for blood glucose clearance. Sex differences regarding the imp...



Effectiveness of erlotinib treatment in advanced KRAS mutation-negative lung adenocarcinoma patients: results of a multicenter observational cohort study (MOTIVATE)
submitted by zoc4817 56 minutes ago - Topic: Health
Erlotinib is an epidermal growth factor receptor tyrosine-kinase inhibitor (EGFR-TKI), used for the treatment of non-small cell lung cancer. As the clinical significance of KRAS mutational status has not yet been clearly determined in this setting, our aim was to investigate the efficacy of erlotinib in advanced KRAS mutation-negative lung adenocarcinoma patients. MOTIVATE is an open-label, mul...

Temporal trends from 1986 to 2008 in overall survival of small cell lung cancer patients
submitted by zoc4817 56 minutes ago - Topic: Health
An assessment of temporal trends in patient survival is important to determine the progress towards patient outcomes and to reveal where advancements must be made. This study assessed temporal changes spanning 22 years in demographics, clinical characteristics, and overall survival of small cell lung cancer (SCLC) patients. This analysis included 1,032 SCLC patients spanning two time-periods fr...

Technical feasibility of real-time elastography to assess the peri-oral region in patients affected by systemic sclerosis
submitted by lenogholeb 1 hour ago - Topic: Health
To evaluate the technical feasibility of real-time elastography (RTE) to assess the stiffness of the skin of the peri-oral region in patients affected by systemic sclerosis (SSc). Six female patients affected by SSc (median age = 52 years) presenting with microstomia and six healthy controls matched for age and sex underwent RTE evaluation of the peri-oral region. Two operators with differen...

Renal transplantation parenchymal complications: what Doppler ultrasound can and cannot do
submitted by lenogholeb 1 hour ago - Topic: Health
Kidney transplantation is the treatment of choice in end-stage renal disease, given the better quality of life of transplanted patients when compared with patients on maintenance dialysis. In spite of surgical improvements and new immunosuppressive regimens, parts of transplanted grafts still develop chronic dysfunction. Ultrasonography, both in B-mode and with Doppler ultrasound, is an importa...



Emerging mass spectrometry techniques for the direct analysis of microbial colonies
submitted by gmahommody 1 hour ago - Topic: Biology
One of the emerging areas in microbiology is detecting specialized metabolites produced by microbial colonies and communities with mass spectrometry. In this review/perspective, we illustrate the emerging mass spectrometry methodologies that enable the interrogation of specialized metabolites directly from microbial colonies. Mass spectrometry techniques such as imaging mass spectrometry and re...

Bacterial gasotransmitters: an innate defense against antibiotics
submitted by gmahommody 1 hour ago - Topic: Biology
In recent decades, there has been growing interest in the field of gasotransmitters, endogenous gaseous signaling molecules (NO, H2S, and CO), as regulators of a multitude of biochemical pathways and physiological processes. Most of the concerted effort has been on eukaryotic gasotransmitters until the subsequent discovery of bacterial counterparts. While the fundamental aspects of bacterial ga...


Antimicrobial and Antioxidant Activities of Bauhinia racemosa Lam. and Chemical Content
submitted by goleles 1 hour ago - Topic: Health
Methanol 70% extract of Bauhinia racemosa aerial parts was tested for antimicrobial activity against different bacterial and fungal strains and for antioxidant activity and also total content of polyphenols with phytochemical analysis of the extract was determined. The results have showed that the extract has a significant antimicrobial activity, it inhibited the growth of Bacillus subtilis and...

A Randomized Clinical Trial Study: Anti-Oxidant, Anti-hyperglycemic and Anti-Hyperlipidemic
submitted by goleles 1 hour ago - Topic: Health
Diabetes is a common metabolic disease in the world that has many adverse effects. Olibanum gum resin (from trees of the genus Boswellia) has traditionally been used in the treatment of various diseases such as diabetes. The aim of this study was the comparison of Olibanum gum resin effect with placebo on the treatment of type 2 diabetes. Inclusion criteria was diabetic patients with fasting bl...


Chain drugstores: Opportunities and Threats
submitted by goleles 1 hour ago - Topic: Health
According to non-official data, despite official ban, over 50% of the pharmacies in Tehran are illegally managed by non pharmacist investors. It means despite the regulations ban, tendency to Chain pharmacy exist in Iran and some investor has more than 10 pharmacies. It means despite the regulations, tendency to Chain pharmacy exist. Benchmarking in other countries shows some advantages and dis...

Treatment of Supination Deformity for Obstetric Brachial Plexus Injury: A Systematic Review and Meta-Analysis
submitted by printpok 1 hour ago - Topic: Health
To conduct a systematic review and meta-analysis of the literature evaluating treatment outcome for supination deformity in obstetric brachial plexus injury. We included studies on brachial plexus and supination deformity with follow-up of at least one year and quantitative measurements of forearm mean passive pronation and position at rest. Meta-analysis was used to explore modifying factors. ...


Distribution of Coronoid Fracture Lines by Specific Patterns of Traumatic Elbow Instability
submitted by printpok 1 hour ago - Topic: Health
To determine if specific coronoid fractures relate to specific overall traumatic elbow instability injury patterns and to depict any relationship on fracture maps and heat maps. We collected 110 computed tomography (CT) studies from patients with coronoid fractures. Fracture types and pattern of injury were characterized based on anteroposterior and lateral radiographs, 2- and 3-dimensional CT ...

Little Finger Carpometacarpal Arthroplasty Technique and Result in 3 Cases
submitted by printpok 1 hour ago - Topic: Health
To present our surgical technique and results for the treatment of posttraumatic arthritis of the little finger carpometacarpal (CMC) joint. We performed a retrospective review of 3 patients who underwent our surgical technique. All patients had previously sustained intra-articular fractures of the base of the little finger metacarpal and presented with painful posttraumatic arthritis of the fi...

Comparison of Grip Strength Among 6 Grip Methods
submitted by printpok 1 hour ago - Topic: Health
To measure grip strengths using several methods by serially excluding 1 or 2 phalanges using a flexion-block orthosis and comparing those with standard grip posture in order to facilitate prediction of clinical or functional outcomes that relate to the contribution of each finger to grip strength. Two hundred healthy men aged 25 to 30 years were included in the survey. Demographic variables wer...

Radiation Exposure to Hand Surgeons’ Hands: A Practical Comparison of Large and Mini C-Arm Fluoroscopy
submitted by printpok 1 hour ago - Topic: Health
To determine and compare the radiation exposure to surgeons’ hands with large and mini C-arm fluoroscopy in a practical, clinically based model. Two hand surgeons monitored radiation exposure to their hands with a ring dosimeter over a 14-month period using large and mini C-arm fluoroscopic units. One surgeon performed all cases with a large C-arm unit in a hospital setting, and the other per...