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Do Regions Make a Difference? Regional Innovation Systems and Global Innovation Networks in the ICT Industry
submitted by odmerjaga 21 minutes ago - Topic: Geography
Access to global innovation networks (GINs) has been unequal across the regions of the world. While certain regions are considered knowledge hubs in GINs, others still remain marginalized; this points to the role of regional innovation systems (RISs) in the emergence and development of GINs. Using firm-level data collected through a survey and case studies in 2009–2010, this paper systematica...



Blue light-filtering intraocular lenses and post-operative mood: a pilot clinical study
submitted by moxmandimbo 21 minutes ago - Topic: Health
The purpose of the study was to determine if implantation of blue-filtering intraocular lenses (IOLs) affects post-operative mood, inducing more depression, compared to patients undergoing implantation with conventional IOLs. The study was conducted at the Angers University Hospital, France. This was a prospective with a lowercase pilot study, including consecutive patients planned to undergo c...

Mouse Models of Hepatitis B Virus Infection Comprising Host-Virus Immunologic Interactions
submitted by blaigriinarongi 22 minutes ago - Topic: Health
Hepatitis B virus (HBV) infection is one of the most prevalent infectious diseases associated with various human liver diseases, including acute, fulminant and chronic hepatitis; liver cirrhosis; and hepatocellular carcinoma. Despite the availability of an HBV vaccine and the development of antiviral therapies, there are still more than 350 million chronically infected people worldwide, approxi...

Contributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer
submitted by tormik97 22 minutes ago - Topic: Health
Chondroitin sulfate proteoglycans (CSPGs) are a diverse family of extracellular matrix (ECM) molecules that make significant contributions to the patterning and routing of migrating neural cells and extending axons. Three distinct modes of migration mediation result from the relative abundance and positioning of expressed CSPGs, the profile of CSPG receptors expressed by the motile cell types, ...

Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases
submitted by tormik97 22 minutes ago - Topic: Health
Signaling pathways and cellular processes that regulate neural development are used post-developmentally for proper function and maintenance of the nervous system. Genes that have been studied in the context of the development of Drosophila peripheral nervous system (PNS) and neuromuscular junction (NMJ) have been identified as players in the pathogenesis of human neurodegenerative diseases, in...



Axon and dendritic trafficking
submitted by tormik97 22 minutes ago - Topic: Health
Neuronal trafficking is crucial to the formation and dynamics of presynaptic and postsynaptic structures and the development and maintenance of axonal and dendritic processes. The mechanism for delivering specific organelles and synaptic molecules in axons and dendrites primarily depends on molecular motor proteins that move along the cytoskeleton. Adaptor proteins, regulatory molecules and loc...

Clinical pharmacology and regulatory consequences of GnRH analogues in prostate cancer
submitted by enktvlik 24 minutes ago - Topic: Health
GnRH (gonadotropin-releasing hormone) analogues are long-term known to be safe and effective in the clinical management of hormone-dependent advanced prostate cancer. However, their unusual mechanism of action of de-sensitizing pituitary receptors makes generic market entry challenging. In addition, safety aspects like initial flare-up, breakthrough escape, and miniflares render planning and or...


Tumor necrosis factor inhibitor therapy but not standard therapy is associated with resolution of erosion in the sacroiliac joints of patients with axial spondyloarthritis
submitted by stippigald 24 minutes ago - Topic: Health
Radiography is an unreliable and insensitive tool for the assessment of structural lesions in the sacroiliac joints (SIJ). Magnetic resonance imaging (MRI) detects a wider spectrum of structural lesions but has undergone minimal validation in prospective studies. The Spondyloarthritis Research Consortium of Canada (SPARCC) MRI Sacroiliac Joint (SIJ) Structural Score (SSS) assesses a spectrum of...

Classification and characteristics of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study
submitted by stippigald 24 minutes ago - Topic: Health
We investigated the clinical and serological features of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in Japan using data from a nationwide, prospective, inception cohort study. In total, 156 Japanese patients with newly diagnosed AAV were classified according to the European Medicines Agency (EMEA) algorithm with exploratory surrogate markers for AAV-rel...


The Mindful Couple
submitted by welcos3221 25 minutes ago - Topic: Health
Couples who request conjoint treatment often demonstrate relationship problems that are exacerbated by emotional reactivity. Neurobiology research has clarified the process of emotional dysregulation, and the benefit of mindful interventions in managing and preventing hyperarousal. This paper examines the mechanics of emotional dysregulation and presents a case example that demonstrates how bre...

Membrane ectopeptidases targeted by human coronaviruses
submitted by qayhap2080 25 minutes ago - Topic: Agriculture
Six coronaviruses, including the recently identified Middle East respiratory syndrome coronavirus, are known to target the human respiratory tract causing mild to severe disease. Their interaction with receptors expressed on cells located in the respiratory tract is an essential first step in the infection. Thus far three membrane ectopeptidases, dipeptidyl peptidase 4 (DPP4), angiotensin-conve...


Viral microRNA genomics and target validation
submitted by qayhap2080 25 minutes ago - Topic: Agriculture
A subset of viruses express their own microRNAs (miRNAs) and one way to understand the functions of these microRNAs is to identify the targets of these miRNAs. Sequence analysis and mRNA expression profiling were some of the first techniques to identify targets of viral miRNAs. More recently, proteomics and sequencing of RNA by crosslinking and immunoprecipitation (CLIP) methods have been insig...

An unusual case of pancytopenia in a nonagenarian: visceral leishmaniasis
submitted by engpokaco 25 minutes ago - Topic: Health
Older patients referred for further investigation of pancytopenia is common in internal medicine and geriatric clinics and it is important to consider a wide range of underlying diagnoses. We present an unusual case of febrile pancytopenia in a nonagenarian who was diagnosed with visceral leishmaniasis. This is a rare and unusual diagnosis in nonagenarians, although the leishmaniasis is endemic...

A Review of Sustainable Urban Drainage Systems Considering the Climate Change and Urbanization Impacts
submitted by tohmod 27 minutes ago - Topic: Biology
Climate change and urbanization are converging to challenge city drainage infrastructure due to their adverse impacts on precipitation extremes and the environment of urban areas. Sustainable drainage systems have gained growing public interest in recent years, as a result of its positive effects on water quality and quantity issues and additional recreational amenities perceived in the urban l...

The Prediction Methods for Potential Suspended Solids Clogging Types during Managed Aquifer Recharge
submitted by tohmod 27 minutes ago - Topic: Biology
The implementation and development of managed aquifer recharge (MAR) have been limited by the clogging attributed to physical, chemical, and biological reactions. In application field of MAR, physical clogging is usually the dominant type. Although numerous studies on the physical clogging mechanism during MAR are available, studies on the more detailed suspended clogging types and its predicti...