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Interleukin-10 gene promoter polymorphisms in celiac patients from north-eastern Italy
submitted by swopnelorvi 13 minutes ago - Topic: Health
Celiac disease is a complex chronic intestinal disorder driven by an immune response against the gliadin fraction of gluten: many factors are involved in the pathogenesis of the disease, and among these Interleukin-10 could play an important role. In the present study, the -1082A>G, -819T>C and -592A>C IL10 functional polymorphisms were analyzed in 565 celiac patients and 5...



Identification of patients with increased immunological risk among potential kidney recipients in the Polish population
submitted by swopnelorvi 13 minutes ago - Topic: Health
Pretransplant identification of allosensitized patients is possible thanks to new technologies, which allow for accurate detection of clinically relevant alloantibodies. Implementation of these methods in the screening of patients awaiting transplantation increased their chance for successful donor-recipient matching. Here, 1460 patients reported to the Polish National Waiting List were screene...

Induction of suppressive phenotype in monocyte-derived dendritic cells by leukemic cell products and IL-1β
submitted by swopnelorvi 13 minutes ago - Topic: Health
Professional antigen-presenting cells, dendritic cells (DCs) play an important role in controlling tumors. It is known that solid tumor cell products inhibit DC differentiation. Recently a similar effect produced by leukemic cell products has been demonstrated. In this case, leukemic cell products induced the secretion of IL-1β by mononuclear cells undergoing differentiation. The aim of the pr...

Low density lipoprotein promotes human naive T cell differentiation to Th1 cells
submitted by swopnelorvi 13 minutes ago - Topic: Health
Oxidized LDL (oxLDL) in the arterial wall and its incorporation into foam cells leads to inflammation and nucleation of atherosclerotic plaque; this is opposed by HDL. OxLDL and HDL regulate activation of macrophages and endothelial cells, and study of T cell participation has been limited to mature, differentiated cells such as Th1 cells, which perpetuate atherogenesis by promoting cell-mediat...

Genetic variations of SOCS1 are associated with chronic hepatitis B virus infection
submitted by swopnelorvi 13 minutes ago - Topic: Health
Suppressor of cytokine signaling (SOCS)-1 is involved in viral infection through regulation of both innate and adaptive immunity. The SOCS1 gene polymorphisms may affect the outcome of viral infection. The relationship between SOCS1 polymorphisms and hepatitis B virus (HBV) infection has not yet been explored. This study genotyped SOCS1 rs243327 and rs33932899 polymorphisms in 477 patients with...



ChIP-less analysis of chromatin states
submitted by omanca 13 minutes ago - Topic: Biology
Histone post-translational modifications (PTMs) are key epigenetic regulators in chromatin-based processes. Increasing evidence suggests that vast combinations of PTMs exist within chromatin histones. These complex patterns, rather than individual PTMs, are thought to define functional chromatin states. However, the ability to interrogate combinatorial histone PTM patterns at the nucleosome lev...

A Nutrient Combination that Can Affect Synapse Formation
submitted by oshliik16 14 minutes ago - Topic: Health
Brain neurons form synapses throughout the life span. This process is initiated by neuronal depolarization, however the numbers of synapses thus formed depend on brain levels of three key nutrients—uridine, the omega-3 fatty acid DHA, and choline. Given together, these nutrients accelerate formation of synaptic membrane, the major component of synapses. In infants, when synaptogenesis is maxi...


Epigenetic Effects of Human Breast Milk
submitted by oshliik16 14 minutes ago - Topic: Health
A current aim of nutrigenetics is to personalize nutritional practices according to genetic variations that influence the way of digestion and metabolism of nutrients introduced with the diet. Nutritional epigenetics concerns knowledge about the effects of nutrients on gene expression. Nutrition in early life or in critical periods of development, may have a role in modulating gene expression, ...

Obesity and Lifespan Health—Importance of the Fetal Environment
submitted by oshliik16 14 minutes ago - Topic: Health
A marked increase in the frequency of obesity at the population level has resulted in an increasing number of obese women entering pregnancy. The increasing realization of the importance of the fetal environment in relation to chronic disease across the lifespan has focused attention on the role of maternal obesity in fetal development. Previous studies have demonstrated that obesity during ado...


In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts
submitted by oshliik16 14 minutes ago - Topic: Health
Drynariae rhizoma has been used to prevent bone loss that occurs with increasing age. However, the chemical compounds in extracts that act on bone metabolism in herbal medicine are poorly understood. This study aimed to investigate and compare the extraction efficacy of polyphenolic compounds, antioxidant activity, and in vitro anti-osteoporosis properties of water extract (DR-DW) and ethanol e...

Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline
submitted by oshliik16 14 minutes ago - Topic: Health
This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human studies that implicate AA in the continuum between normal cognitive aging and age-related cognitive...


Chronic Kidney Disease and ICD Related Complications: 16 Years of Experience
submitted by morgi 14 minutes ago - Topic: Health
ICD implantation has become an accepted therapy for the prevention of sudden cardiac death. However, serious co-morbidities such as chronic kidney disease (CKD) are influencing the beneficial effects of ICD therapy. In this study the association between kidney function and the occurrence of ICD related complications was assessed. All patients receiving an ICD or CRT-D between 1996 and 2012 were...

Repeated Radiofrequency Ablation of Atrial Tachycardia in Restrictive Cardiomyopathy Secondary to Myofibrillar Myopathy
submitted by morgi 14 minutes ago - Topic: Health
Myofibrillar myopathy is characterized by non-hyaline and hyaline lesions due to mutations in nuclear genes encoding for extra-myofibrillar or myofibrillar proteins. Cardiac involvement in myofibrillar myopathy may be phenotypically expressed as dilated, hypertrophic or restrictive cardiomyopathy. Radiofrequency ablation of atrial fibrillation and flutter has so far not been reported in myofibr...

Compatibility of Electroanatomical Mapping Systems with a Concurrent Percutaneous Axial Flow Ventricular Assist Device
submitted by morgi 14 minutes ago - Topic: Health
Hemodynamic instability hinders activation and entrainment mapping during ventricular tachycardia (VT) ablation. The Impella 2.5 microaxial flow device (MFD) (Abiomed Inc., Danvers, MA, USA) is used to prevent hemodynamic instability during electrophysiologic study. However, electromagnetic interference (EMI) generated by this device can preclude accurate electroanatomic mapping. Impella was pl...

Early Procedure-related Adverse Events by Gender in MADIT-CRT
submitted by morgi 14 minutes ago - Topic: Health
Whether gender differences exist in procedure-related adverse events following CRT-D implantation is unknown. We investigated the type and frequency of procedure-related adverse events among those enrolled in MADIT-CRT and identified clinical predictors for gender-specific events. We compared differences in the rate of procedure-related adverse events by gender (444 females and 1,346 males) tha...