Biology Agriculture Aquaculture Horticulture Postharvest Forestry Geography Environment Health





View All

Personalized cost-effectiveness of boceprevir-based triple therapy for untreated patients with genotype 1 chronic hepatitis C
submitted by solvodar 10 minutes ago - Topic: Health
We assessed the cost-effectiveness of boceprevir-based triple therapy compared to peginterferon alpha and ribavirin dual therapy in untreated patients with genotype 1 chronic hepatitis C; patients were discriminated according to the combination of baseline plus on-treatment predictors of boceprevir-based triple therapy. Cost-effectiveness analysis performed according to data from the available ...



Examining Stakeholders' Perceptions of Mining Impacts and Corporate Social Responsibility
submitted by tokir222333 32 minutes ago - Topic: Environment
This paper aims to provide a better understanding of multistakeholder perceptions of corporate social responsibility (CSR) in connection with mining industry impacts. While there is significant research about CSR, there is a lack of understanding in the area of specific stakeholders' perceptions within the extractive industry, particularly in a developing country like Chile. The findings reveal...

Poverty Reduction through Empowerment for Sustainable Development: A Proactive Strategy of Corporate Social Responsibility
submitted by tokir222333 32 minutes ago - Topic: Environment
Targeting the serious poverty problem of the world, this study proposes a proactive strategy for enterprises to fulfill their corporate social responsibility (CSR). The study interprets the cause of poverty from the perspectives of human capital theory and labor market theory, and examines the business functions that can be deployed in helping the poor from an empowerment theory perspective. Th...

Influenza A(H1N1)pdm09 resistance and cross-decreased susceptibility to oseltamivir and zanamivir antiviral drugs
submitted by beacamp 34 minutes ago - Topic: Health
Neuraminidase inhibitors (NAIs) oseltamivir and zanamivir are currently the only effective antiviral drugs available worldwide for the management of influenza. The potential development of resistance is continually threatening their use, rationalizing and highlighting the need for a close and sustained evaluation of virus susceptibility. This study aimed to analyze and characterize the phenotyp...

Hepatitis C virus NS3 protease genotyping and drug concentration determination during triple therapy with telaprevir or boceprevir for chronic infection with genotype 1 viruses, southeastern France
submitted by beacamp 34 minutes ago - Topic: Health
Telaprevir and boceprevir, the two first hepatitis C virus (HCV) NS3 protease inhibitors (PIs), considerably increase rates of sustained virologic response in association with pegylated interferon and ribavirin in chronic HCV genotype 1 infections. The 30 first patients treated by telaprevir or boceprevir including anti-HCV therapies since 2011 in Marseille University hospitals, France, were mo...



A closer look at rituximab induction on HLA antibody rebound following HLA-incompatible kidney transplantation
submitted by mgroceo 47 minutes ago - Topic: Health
Rituximab has been used to increase the efficacy of desensitization protocols for human leukocyte antigen (HLA)-incompatible kidney transplantation; however, controlled comparisons have not been reported. Here we examined 256 post-transplant HLA antibody levels in 25 recipients desensitized with and 25 without rituximab induction, to determine the impact of B-cell depletion. We found significan...

A multicenter randomized trial indicates initial prednisolone treatment for childhood nephrotic syndrome for two months is not inferior to six-month treatment
submitted by mgroceo 51 minutes ago - Topic: Health
In this multicenter, open-label, randomized controlled trial, we determined whether 2-month prednisolone therapy for steroid-sensitive nephrotic syndrome was inferior or not to 6-month therapy despite significantly less steroid exposure. The primary end point was time from start of initial treatment to start of frequently relapsing nephrotic syndrome. The pre-specified non-inferiority margin wa...


APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes
submitted by mgroceo 51 minutes ago - Topic: Health
Albuminuria and reduced estimated glomerular filtration rate (eGFR) associate with two apolipoprotein L1 gene (APOL1) variants in nondiabetic African Americans (AAs). Whether APOL1 associates with subclinical atherosclerosis and survival remains unclear. To determine this, 717 African American-Diabetes Heart Study participants underwent computed tomography to determine coronary artery-, carotid...

The role of adenosine receptors A2A and A2B signaling in renal fibrosis
submitted by mgroceo 59 minutes ago - Topic: Health
Renal fibrosis, the key histopathological lesion in the development and progression of chronic kidney disease (CKD), has been the focus of much research in recent decades. The growing burden of CKD in both developed and developing nations highlights a need for novel therapies to halt the progression of renal disease. Insights into the pathogenesis of renal fibrosis and the key cellular and mole...


Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation
submitted by aloisso3110 1 hour ago - Topic: Health
Intrathecal oligoclonal bands of the cerebrospinal fluid are considered the most important immunological biomarkers of multiple sclerosis. They typically consist of clonally expanded IgG antibodies that underwent affinity maturation during sustained stimulation by largely unknown antigens. In addition, ~40% of patients with multiple sclerosis have oligoclonal bands that consist of expanded IgM ...

Genetic transformation of Fusarium avenaceum by Agrobacterium tumefaciens mediated transformation and the development of a USER-Brick vector construction system
submitted by ntgrzych 1 hour ago - Topic: Biology
The plant pathogenic and saprophytic fungus Fusarium avenaceum causes considerable in-field and post-field losses worldwide due to its infections of a wide range of different crops. Despite its significant impact on the profitability of agriculture production and a desire to characterize the infection process at the molecular biological level, no genetic transformation protocol has yet been est...


A protocol for machine-readable cache policies in OGC web services: Application to the EuroGeoSource information system
submitted by pandhiiponkor 1 hour ago - Topic: Environment
An efficient access to the contents provided through OGC web services, widely used in environmental information systems, is usually achieved by means of caching strategies. Service-owners may be interested in expressing the conditions required to allow for this. If these conditions are expressed in a machine-readable way, automatic harvesters can be programmed to follow them. This paper propose...

A decision support system for on-line leakage localization
submitted by pandhiiponkor 1 hour ago - Topic: Environment
This paper describes a model-driven decision-support system (software tool) implementing a model-based methodology for on-line leakage detection and localization which is useful for a large class of water distribution networks. Since these methods present a certain degree of complexity which limits their use to experts, the proposed software tool focuses on the integration of a method emphasizi...

Improving the predictive power of spatial statistical models of stream macroinvertebrates using weighted autocovariance functions
submitted by pandhiiponkor 1 hour ago - Topic: Environment
Spatial statistical stream-network models are useful for modelling physicochemical data, but to-date have not been fit to macroinvertebrate data. Spatial stream-network models were fit to three macroinvertebrate indices: percent pollution-tolerant taxa, taxa richness and the number of taxalacking out-of-network movement (in-stream dispersers). We explored patterns of spatial autocorrelation in ...

Integrated framework for assessing urban water supply security of systems with non-traditional sources under climate change
submitted by pandhiiponkor 1 hour ago - Topic: Environment
Assessing water supply security for urban water supply system (UWSS) planning is now more challenging with the inclusion of non-traditional sources, which increases simulation complexity, and the need to account for climate change impacts, which increases uncertainty. This paper addresses this by developing an integrated framework for assessing the security of UWSSs with non-traditional sources...