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DNA methylation of apoptosis genes in rectal cancer predicts patient survival and tumor recurrence
submitted by aloisso3110 9 minutes ago - Topic: Biology
Deregulation of the apoptotic pathway, one of the hallmarks of tumor growth and -progression, has been shown to have prognostic value for tumor recurrence in rectal cancer. In order to develop clinically relevant biomarkers, we studied the methylation status of promoter regions of key apoptosis genes in rectal cancer patients, using methylation-sensitive restriction enzymes. DNA was extracted f...

Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA
submitted by ohjarth 24 minutes ago - Topic: Biology
Eukaryotic initiation factor 5b (eIF5B) is essential for translation initiation. Spahn and colleagues now report cryo-EM structures of the mammalian 80S initiation complex associated with eIF5B that redefine eIF5B as a tRNA reorientation factor.

Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2
submitted by ohjarth 24 minutes ago - Topic: Biology
Guettou et al. describe structural studies on a bacterial homolog of PepT1 and PepT2 peptide transporters—nutrient transporters responsible for all peptide transport across the plasma membrane—in complex with three di- or tripeptides. The data suggest how the transporter's broad peptide specificity is achieved.

Fiebre chikungunya - Una nueva amenaza global
submitted by esmoil 38 minutes ago - Topic: Health
Las epidemias causadas, entre otros, por los virus Ébola, Marburgo, Nipah, Lassa, coronavirus, virus del Nilo Occidental, virus de Saint Louis, virus de la inmunodeficiencia humana, dengue, fiebre amarilla y fiebre hemorrágica venezolana han puesto sobre el tapete el riesgo que estos agentes representan para la salud pública global. Entre las nuevas amenazas destaca el virus chikungunya, que...

Algoritmo para el estudio molecular del síndrome de Bardet-Biedl en España
submitted by esmoil 39 minutes ago - Topic: Health
El síndrome de Bardet-Biedl (SBB) es una enfermedad genética multisistémica poco frecuente en población caucásica, caracterizada por una pronunciada variabilidad fenotípica y una gran heterogeneidad genética. Pertenece al grupo de las ciliopatías, causadas por defectos en la estructura y/o función ciliar. Dada la gran complejidad diagnóstica del síndrome, el objetivo de este estudio ...

Potential Conflicting Interests for Surgeons in End-of-Life Care
submitted by swenno 57 minutes ago - Topic: Health
Thirty-day mortality represents a variable that is commonly used to measure the quality of surgical care. The definition of 30-day mortality and the application of a risk adjustment to its measurement may vary among different organizations comparing physician quality. In the midst of this confusion, conflicting interests arise for surgeons who must weigh the potential benefit of surgical interv...

Microbiological accumulation by the Mediterranean invasive alien species Branchiomma bairdi (Annelida, Sabellidae): Potential tool for bioremediation
submitted by geriishkoyyar 1 hour ago - Topic: Geography
We examined the bacterial accumulation and digestion in the alien polychaete Branchiomma bairdi. Microbiological analyses were performed on worm homogenates from “unstarved” and “starved” individuals and on seawater from the same sampling site (Ionian Sea, Italy). Densities of culturable heterotrophic bacteria (22°C), total culturable bacteria (37°C) and vibrios were measured on Marin...

Analysis of the role of DOP on the particulate phosphatase activity in Toulon Bay (N.W. Mediterranean Sea, France)
submitted by geriishkoyyar 1 hour ago - Topic: Geography
Alkaline phosphatase (AP) activity was studied on homogenates of particulate material in relation to the concentrations of AP-hydrolysable (DOPpa) and AP-non hydrolysable (DOPr) phosphorus. AP activity had high and low Km components. The high affinity activity came from ectoenzymes. It was negatively and significantly correlated with DOPr as with the sum of DIP and DOPr, but not with DOPpa. How...

Assessment of ecological quality of coastal lagoons with a combination of phytobenthic and water quality indices
submitted by geriishkoyyar 1 hour ago - Topic: Geography
Coastal lagoons are ecotones between continents and the sea. Coastal lagoons of Western Greece, subjected to different human pressures, were classified into four different types based on their hydromorphological characteristics and monitored over a three year period for their biotic and abiotic features. Six ecological indices based on water quality parameters (TSI-Chl-a, TSI-TP, TRIX), benthic...

Stable isotope ratios of carbon, nitrogen and oxygen in killer whales (Orcinus orca) stranded on the coast of Hokkaido, Japan
submitted by geriishkoyyar 1 hour ago - Topic: Geography
We analyzed δ 13C, δ 15N and δ 18O in the muscle and liver from killer whales stranded on the coast of Japan. The δ 15N values in the muscle samples from calves were apparently higher than those in their lactating mothers, suggesting that nursing may result in the higher δ 15N values in the muscle samples of calves. The δ 15N value in the muscle samples of male and female whales, except f...

Disturbance influences the invasion of a seagrass into an existing meadow
submitted by geriishkoyyar 1 hour ago - Topic: Geography
Future impacts from climate change and human activities may increase the likelihood of invasions of native marine species into existing habitats as a result of range shifts. To provide an understanding of the invasion of a native seagrass species (Syringodiumisoetifolium) into a tropical multi-species meadow, detailed field assessments were conducted over a six year period. After establishing i...

Developing a methodology of bioindication of human-induced effects using seagrass morphological variation in Spermonde Archipelago, South Sulawesi, Indonesia
submitted by geriishkoyyar 1 hour ago - Topic: Geography
Seagrass is particularly susceptible to environmental degradation. The objective of the study is to develop an effective bioindicator to assess human-induced effects using morphological variation and fluctuating asymmetry (FA) of seagrass. Samples were collected from eight islands situated at different distance from mainland with different human population density and therefore expected to expe...

Marine mammals and ocean noise: Future directions and information needs with respect to science, policy and law in Canada
submitted by geriishkoyyar 1 hour ago - Topic: Geography
Marine mammals are ecologically and culturally important species, and various countries have specific legislation to protect the welfare of individual marine mammals and the conservation of their populations. Anthropogenic noise represents a particular challenge for conservation and management. There is a large and growing body of research to support the conclusion that anthropogenic noise can ...

Organotropism of persistent organic pollutants and heavy metals in the Greenland shark Somniosus microcephalus in NE Greenland
submitted by geriishkoyyar 1 hour ago - Topic: Geography
The Greenland shark Somniosus microcephalus is an opportunistic feeder, a top predator, and a very long-lived species. The brain, liver, red and white muscle, gonads, fat, skin, pancreas, and spleen of Greenland sharks from NE Greenland fjords were analysed for PCBs, PCDDs/DFs, PBDEs; DDT isomers; HCH isomers; dieldrin; endrin; HCB; Cd, Hg, Pb, and Se. PCBs (2.01–103ng/gwetwt) and PBDEs (7.9...

Total, methyl and organic mercury in sediments of the Southern Baltic Sea
submitted by geriishkoyyar 1 hour ago - Topic: Geography
Distribution of sedimentary mercury in the Southern Baltic was investigated. Sediment samples were collected from the Southern Baltic in the period from 2009 to 2011, and concentrations of sedimentary total mercury (average 102ng/g, range 5.8–225ng/g) and methyl mercury (average 261pg/g, range 61–940pg/g) were measured in the manner that the influence of both patchiness and seasonal changes...