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Isolation of mitochondria with cubic membrane morphology reveals specific ionic requirements for the preservation of membrane structure
submitted by mene 14 minutes ago - Topic: Biology
Biological membranes with cubic symmetry are a hallmark of virus-infected or diseased cells. The mechanisms of formation and specific cellular functions of cubic membranes, however, are unclear. The best-documented cubic membrane formation occurs in the free-living giant amoeba Chaos carolinense. In that system, mitochondrial inner membranes undergo a reversible structural change from tubular t...



Antiphospholipid antibodies and the placenta: a systematic review of their in vitro effects and modulation by treatment
submitted by chakks 16 minutes ago - Topic: Health
Antiphospholipid antibodies (aPL) are a family of auto-antibodies that are associated with an increased risk of recurrent miscarriage, intrauterine growth restriction and preterm birth. The placenta is a major target of aPL and it is likely that these antibodies promote pregnancy morbidity by affecting trophoblast function. Numerous studies have investigated the effect of aPL on trophoblast fun...

Effects of freeze–thaw cycles on the soil nutrient balances, infiltration, and stability of cyanobacterial soil crusts in northern China
submitted by ogradivca 16 minutes ago - Topic: Agriculture
Freeze–thaw fluctuation is a natural phenomenon, which is frequently encountered by biological soil crusts (BSCs) in late autumn and early spring in cold deserts. The objective of our study was to investigate the effects of freeze–thaw cycles (FTCs) on the soil nutrient balances, infiltration, and stability of cyanobacterial soil crusts (CSCs) in the temperate desert region. A controlled in...

Yanagihara Facial Nerve Grading System as a Prognostic Tool in Bell’s Palsy
submitted by friidamzn 17 minutes ago - Topic: Health
The aim of this study was to evaluate the accuracy of the Yanagihara facial nerve grading system in assessing the course of recovery and in determining the probability of a complete recovery of Bell’s palsy within 1 week after onset. Study DesignRetrospective study of patients at a single trial center. SettingTertiary referral center. PatientsSix hundred sixty-four patients with Bell’s pals...

Intratympanic Steroid Injection for Bell’s Palsy: Preliminary Randomized Controlled Study
submitted by friidamzn 17 minutes ago - Topic: Health
To investigate adjuvant effect and safety of intratympanic steroid for the treatment of Bell’s palsy. Study DesignProspective, investigator blinded, randomized study. SettingTertiary referral center. PatientsPatients who received treatment for Bell’s palsy from December 2007 to March 2011 were randomly divided into two groups. The control group (n = 17) was treated with systemic steroid plu...



Emotional Intelligence in Association With Quality of Life in Patients Recently Diagnosed With Vestibular Schwannoma
submitted by friidamzn 17 minutes ago - Topic: Health
The objective of this study was two-fold. First, to examine the levels of emotional intelligence in patients recently diagnosed with vestibular schwannoma, in comparison to those of healthy individuals and patients with other physical illness. Second, to evaluate the correlation between Emotional Intelligence and quality of life. Study DesignCross sectional study in a university tertiary referr...

Neurofibromatosis 2 Invasion of the Internal Auditory Canal Wall: Clinical Significance
submitted by friidamzn 17 minutes ago - Topic: Health
To describe the infiltration of severe phenotype (“Wishart”) neurofibromatosis type 2 (NF2)–related vestibular nerve schwannomas (VSs) into the internal auditory canal wall in contrast to sporadic VS and the milder (“Gardner”) phenotype NF2-related VS. Study DesignRetrospective case series involving microscopic examination and review of clinical history. SettingTemporal bone laborator...


Cervical Vestibular Evoked Myogenic Potentials in Cerebellar Lesions
submitted by friidamzn 17 minutes ago - Topic: Health
Reports about cervical vestibular evoked myogenic potentials (cVEMPs) in central nervous system lesions are scarce. Our experience with cerebellar lesions is still evolving, with only a few cases published. The purpose of this article is to present our cVEMP findings of 3 cases with cerebellar lesions. cVEMPs were performed using unilateral 120-dB peak SPL intensity 1 kHz tone air-conducted sou...

Intratympanic Dexamethasone as a Symptomatic Treatment for Ménière’s Disease
submitted by friidamzn 17 minutes ago - Topic: Health
Determine whether intratympanic (IT) dexamethasone, when given on an as needed basis, can successfully control Ménière’s disease (MD) symptoms in a large percentage of patients and allow them to avoid ablative therapies. Study DesignRetrospective chart review. SettingTertiary medical center. PatientsOne hundred fifty-nine patients met the American Academy of Otolaryngology–Head and Neck S...


Comparison of Two Different Titanium Couplers for an Active Middle Ear Implant
submitted by friidamzn 17 minutes ago - Topic: Health
To compare surgical methods, functional gain, and speech discrimination using two different coupling methods for an active middle ear implant. Of several couplers enabling placement of the active element at various locations, two function directly at a cochlear membrane, bypassing a missing or malformed ossicular chain. This study evaluates whether either of these methods is more beneficial. Re...

A Simple Algorithm for Treating Horizontal Benign Paroxysmal Positional Vertigo
submitted by friidamzn 17 minutes ago - Topic: Health
Horizontal benign paroxysmal positional vertigo (H-BPPV) is more difficult to successfully treat than posterior benign paroxysmal positional vertigo (P-BPPV) because of the diverse mechanisms required. We developed a simple, rapid, and effective treatment algorithm for treating all subtypes of H-BPPV in an ear, nose, and throat (ENT) outpatient department. Four hundred ninety patients with BPPV...


Sudden Sensorineural Hearing Loss With Simultaneous Positional Vertigo Showing Persistent Geotropic Direction-Changing Positional Nystagmus
submitted by friidamzn 17 minutes ago - Topic: Health
To characterize the clinical features of patients who simultaneously developed ipsilateral sudden sensorineural hearing loss (SSNHL) and positional vertigo showing geotropic direction-changing positional nystagmus (DCPN) on a supine head-roll test, and to address the possible pathophysiology of the disease. Study DesignRetrospective case series review. MethodsWe conducted a retrospective case s...

Round Window Stimulation for Conductive and Mixed Hearing Loss
submitted by friidamzn 17 minutes ago - Topic: Health
Assess surgical complications, postoperative residual hearing, and speech perception outcomes of placement of a middle ear implant on the round window in conductive and mixed hearing loss cases. Study DesignSingle-subject, repeated-measures design where each subject served as his or her own control. SettingTertiary referral medical systems. SubjectsEighteen subjects with either conductive or mi...

Osseointegrated Implants for Auricular Defects: Operative Techniques and Complication Management
submitted by friidamzn 17 minutes ago - Topic: Health
Auricular defects are challenging to reconstruct with native tissue. We describe operative techniques and complication management for patients undergoing osseointegrated implants for auriculectomy defects and microtia. SettingTertiary referral center. PatientsAll patients at Duke University Medical Center with auricular defects treated with osseointegrated implants for prosthetic (OIP) auricles...

Novel Repair of Stapedial Footplate Defect Associated with Recurrent Meningitis
submitted by friidamzn 17 minutes ago - Topic: Health
Recurrent meningitis resulting from a partial defect of the stapedial footplate is most frequently treated by complete obliteration of the inner ear. Herein, we report the use of a partial obliteration technique in which the fistula is plugged with a shaped incus. PatientsA 5-year-old girl and a 7-year-old boy who had congenital inner ear malformations both developed recurrent meningitis. High-...