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Establishment of a new immunological method for direct detection of Mycobacterium in solution
submitted by mkmosry 11 minutes ago - Topic: Biology
Tuberculosis (TB) is a crucial health problem. Prevention of the disease requires rapid diagnosis. Rapid liquid culture systems, nucleic acid amplification tests, and high-performance liquid chromatography (HPLC) are among the rapid tests used for detecting Mycobacterium species. However, these tests are expensive and require extensive equipment and expertise, which is hardly affordable in reso...



Subnormothermic Machine Perfusion for Ex Vivo Preservation and Recovery of the Human Liver for Transplantation
submitted by grenzy 12 minutes ago - Topic: Health
To reduce widespread shortages, attempts are made to use more marginal livers for transplantation. Many of these grafts are discarded for fear of inferior survival rates or biliary complications. Recent advances in organ preservation have shown that ex vivo subnormothermic machine perfusion has the potential to improve preservation and recover marginal livers pretransplantation. To determine th...

Choosing Wisely: The American College of Rheumatology's Top 5 for Pediatric Rheumatology
submitted by warldcev 14 minutes ago - Topic: Health
To create a pediatric rheumatology Top 5 list as part of the American Board of Internal Medicine Foundation's Choosing Wisely campaign. Delphi surveys of a core group of representative pediatric rheumatology providers from across North America generated candidate Top 5 items. Items with high content agreement and perceived to be of prevalent use and of high impact were included in a survey of a...

Socioeconomic disparities in the health of African-Americans with rheumatoid arthritis from the Southeastern USA
submitted by warldcev 14 minutes ago - Topic: Health
To examine cross-sectional baseline data from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis Registry (CLEAR) for the association between socioeconomic status (SES) with clinical and self-report health outcomes. We analyzed data on 937 African Americans (AA) who provided comprehensive sociodemographic data in addition to self-reported health ...

Parental Influence on Systemic Sclerosis (SSc)
submitted by warldcev 14 minutes ago - Topic: Health
The aim of this research was to examine parental influence on the development of Systemic Sclerosis (SSc). We designed three studies: (1) mitochondrial inheritance; birth order (a possible surrogate marker for microchimerism); and paternal age at conception (a possible surrogate for telomere erosion) to examine their association with development of SSc. SSc was defined by International Classifi...



Linking physical function outcomes in rheumatology: Performance of a crosswalk for converting HAQ scores to SF36 PF-10 scores
submitted by warldcev 14 minutes ago - Topic: Health
To evaluate the reliability of a crosswalk that was developed in the Netherlands, between the Health Assessment Questionnaire Disability Index (HAQ-DI) and the SF-36 Physical Functioning scale (PF-10) in a sample of patients with various rheumatic diseases in the United States (US). Baseline data from patients with rheumatoid arthritis (RA,N=29020), fibromyalgia (FM, N=3776), and systemic lupus...

Risk factors for juvenile dermatomyositis: Exposure to tobacco and air pollutants during pregnancy
submitted by warldcev 14 minutes ago - Topic: Health
To evaluate the influence of exposures to inhaled environmental factors during pregnancy on juvenile dermatomyositis (JDM) diagnosis. A case-control study comprising 20 JDM and 56 healthy controls matched by age and gender residents in the metropolitan region of a large city. A questionnaire assessed demographic data and environmental inhalation exposure during pregnancy (occupational exposure ...


Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens
submitted by colthrapi 14 minutes ago - Topic: Biology
Increasing evidence supports a role for altered gene expression in mediating the lasting effects of cocaine on the brain, and recent work has demonstrated the involvement of chromatin modifications in these alterations. However, all such studies to date have been restricted by their reliance on microarray technologies that have intrinsic limitations. :We use next generation sequencing methods, ...

A novel biological role of dehydroascorbic acid: inhibition of Na+-dependent transport of ascorbic acid
submitted by mythamethros 15 minutes ago - Topic: Health
A U937 cell clone, in which low micromolar concentrations of ascorbic acid (AA) and dehydroascorbic acid (DHA) are taken up at identical rates, was used to investigate possible interactions between transport systems mediating cellular uptake of the two forms of the vitamin. obtained with different experimental approaches showed that DHA potently and reversibly inhibits aA uptake through Na+-AA ...


Exendin-4 inhibits endothelial protein C receptor shedding in vitro and in vivo
submitted by mythamethros 15 minutes ago - Topic: Health
Exendin-4 (EX4), a glucagon-like peptide-1 receptor agonist, has been reported to attenuate myocardial ischemia and reperfusion (I/R) injury, inflammatory and oxidative responses. Increasing evidence has demonstrated that beyond its role in activation of protein C, endothelial cell protein C receptor (EPCR) is involved in vascular inflammation. EPCR activity is markedly decreased by ectodomain ...

Early Life Exposure to Fructose and Offspring Phenotype: Implications for Long Term Metabolic Homeostasis
submitted by oleghell 16 minutes ago - Topic: Health
The consumption of artificially sweetened processed foods, particularly high in fructose or high fructose corn syrup, has increased significantly in the past few decades. As such, interest into the long term outcomes of consuming high levels of fructose has increased significantly, particularly when the exposure is early in life. Epidemiological and experimental evidence has linked fructose con...


Exaggerated reaction to novelty as a subclinical consequence of mild traumatic brain injury
submitted by swenno 16 minutes ago - Topic: Health
To evaluate exaggerated reaction to novelty as a behavioural marker of sub-clinical cognitive dysfunction in individuals with a history of mild traumatic brain injury (mTBI). and hypothesis: A sub-set of individuals who sustain mTBIs report persistent cognitive difficulties despite normal performance on traditional neuropsychological measures. Evidence of subtle neuroimaging abnormalities follo...

Versional eye tracking in mild traumatic brain injury (mTBI): Effects of oculomotor training (OMT)
submitted by swenno 17 minutes ago - Topic: Health
To evaluate a range of objective measures of versional eye movements before and after oculomotor training (OMT) in individuals with mTBI. The results were compared with placebo (P) training. Twelve individuals with mTBI (mean age = 29 ± 3 years) having oculomotor-based near-vision symptoms participated in the study. Versional eye movements were recorded objectively before and after OMT...

Technical aspects of repair of juxtarenal abdominal aortic aneurysms using the Zenith fenestrated endovascular stent graft
submitted by tammol32 18 minutes ago - Topic: Health
Fenestrated endovascular aortic repair has been used with increasing frequency to treat complex aortic aneurysms. The Zenith fenestrated stent graft system (Cook Medical Inc, Brisbane, Queensland, Australia) was approved for commercial use in the United States in April 2012, offering a custom-made design with up to three fenestrations to treat short-neck infrarenal and juxtarenal abdominal aort...

Operative and nonoperative management of chronic disseminated intravascular coagulation due to persistent aortic endoleak
submitted by tammol32 18 minutes ago - Topic: Health
Disseminated intravascular coagulation (DIC) due to endoleak is a rare complication following endovascular aneurysm repair. Two of the four previously reported cases occurred in patients with cirrhosis. We describe three patients with normal liver function who developed DIC due to delayed high-flow (type Ia or III) endoleaks. Two patients underwent successful surgical repair, and the third was ...