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Verweildauer von Patienten mit hüftgelenknahen Femurfrakturen
submitted by cmontico 18 minutes ago - Topic: Health
In orthopädisch-unfallchirurgischen Kliniken bilden Patienten mit hüftgelenknahen Frakturen den größten Anteil traumatisierter Patienten. Deren stationäre Verweildauer (VWD) hat ökonomische Auswirkungen und führt bei Verlängerung zu einer Verknappung der Bettenkapazität. Versorgungs- sowie patientenbezogene Faktoren, die die stationäre VWD von Patienten mit hüftgelenksnahen Frakturen...



What Turns on a Migraine? A Systematic Review of Migraine Precipitating Factors
submitted by tozzaka 18 minutes ago - Topic: Health
Migraine attacks rarely occur spontaneously in the absence of any possible precipitating factors. A systematic literature review of 25 publications revealed a consistent set of stimuli that have been identified as factors associated with the onset of a migraine attack. The weighted average of the “Top 10” trigger factors was determined. Stress was cited as the overall most common migraine p...

Cannabinoids for Neuropathic Pain
submitted by tozzaka 18 minutes ago - Topic: Health
Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a range of experimental neuropathic pain models, and there is mounting evidence...

Gait Analysis Methods for Rodent Models of Osteoarthritis
submitted by tozzaka 18 minutes ago - Topic: Health
Patients with osteoarthritis (OA) primarily seek treatment due to pain and disability, yet the primary endpoints for rodent OA models tend to be histological measures of joint destruction. The discrepancy between clinical and preclinical evaluations is problematic, given that radiographic evidence of OA in humans does not always correlate to the severity of patient-reported symptoms. Recent adv...

Sufficiency and Necessity in Migraine: How do we Figure Out if Triggers are Absolute or Partial and, if Partial, Additive or Potentiating?
submitted by tozzaka 18 minutes ago - Topic: Health
Migraine is, to a great extent, a genetically determined disorder and once it has manifested itself, it generally continues for years if not for decades. While the migraine is active, headaches can seemingly occur spontaneously but are often reportedly precipitated by events or factors, known as migraine triggers, the interplay of which is the topic of this paper. Among migraine triggers, the m...



Primary Stabbing Headache in Adults and Pediatrics: a Review
submitted by tozzaka 18 minutes ago - Topic: Health
Primary stabbing headache (PSH) is an under-recognized primary headache disorder, which often goes undiagnosed. It is mainly characterized by its ultrashort stabbing quality and can be easily overlooked both by patients and providers as it is often not severe enough to interfere significantly with daily life. However, PSH may be severe and require therapy, and it is important for providers to r...

Hippocampal Atrophy Varies by Neuropsychologically-Defined MCI among Men in Their 50s
submitted by hindrekm 27 minutes ago - Topic: Health
In an effort to address earliest detection of Mild Cognitive Impairment (MCI), we examined hippocampal volumes and atrophy in middle-aged males to explore neuroanatomical support for different neuropsychological definitions of MCI. 460 men ages 51-60 underwent neuropsychological testing and an MRI. MCI was defined according to five criteria sets. MRI-derived hippocampal volume and hippocampal o...


Lactate retards development of erythrocytic stages of the human malaria parasite Plasmodium falciparum
submitted by lesdo 27 minutes ago - Topic: Biology
The intraerythrocytic form of the human malaria parasite Plasmodium falciparum relies on glycolysis for its energy requirements. In glycolysis, lactate is an end product. It is therefore known that lactate accumulates in in vitro culture; however, its influence on parasite growth remains unknown. Here we investigated the effect of lactate on the development of P. falciparum during in vitro cult...

Open Access Data Sharing in Genomic Research
submitted by aloisso3110 28 minutes ago - Topic: Biology
The current emphasis on broad sharing of human genomic data generated in research in order to maximize utility and public benefit is a significant legacy of the Human Genome Project. Concerns about privacy and discrimination have led to policy responses that restrict access to genomic data as the means for protecting research participants. Our research and experience show, however, that a consi...


What has been happening with viroids?
submitted by shohen76 28 minutes ago - Topic: Health
Viroids are naked nucleic acids that do not code for any proteins and yet are able to be replicated, processed, moved cell-to-cell and systemically through their host plants, as well as resist plant defense response and be transmitted from plant to plant, without a protective coat. All of the information specifying these functions lies within their nucleotide sequence and the RNA structures the...

Presence of external carotid artery plaque independently predicts mortality in patients without internal carotid artery atherosclerosis
submitted by tamradd 30 minutes ago - Topic: Health
The presence of plaque in the external carotid artery (ECA) detected on carotid duplex ultrasound (CDU) is of unknown clinical significance and may not be reported in routine clinical practice. We hypothesize that ECA plaque in the absence of plaque in the other cervical vessels is a risk factor for increased all-cause mortality. To determine the significance of ECA plaque on all-cause mortalit...


Brain Metastasis is Predetermined in Early-Stages of Cutaneous Melanoma by CD44v6 Expression through Epigenetic Regulation of the Spliceosome
submitted by cilibe 31 minutes ago - Topic: Biology
Melanoma brain metastasis (MBM) is frequent and has a very poor prognosis with no current predictive factors or therapeutic molecular targets. Our study unravels the molecular alterations of cell-surface glycoprotein CD44 variants during melanoma progression to MBM. High expression of CD44 splicing variant 6 (CD44v6) in primary melanoma (PRM) and regional lymph node metastases from AJCC Stage I...

Accounting for Photophysical Processes and Specific Signal Intensity Changes in Fluorescence-Detected Sedimentation Velocity
submitted by mene 32 minutes ago - Topic: Geography
Fluorescence detected sedimentation velocity (FDS-SV) has emerged as a powerful technique for the study of high-affinity protein interactions, with hydrodynamic resolution exceeding that of diffusion-based techniques, and with sufficient sensitivity for binding studies at low picomolar concentrations. For the detailed quantitative analysis of the observed sedimentation boundaries, it is necessa...

Two new species of Pleroma (Melastomataceae: Melastomeae) from Brazil
submitted by mozinrhl 32 minutes ago - Topic: Biology
Two new species of Pleroma D. Don (Melastomataceae: Melastomeae) from Brazil are described and illustrated here. Pleroma caissara F. S. Mey. and P. guartelaensis F. S. Mey & R. Goldenb. have been repeatedly determined and recognised in taxonomic treatments respectively as Tibouchina regnellii Cogn. and T. riedeliana Cogn. P. caissara can be recognised by the arboreal habit, dichasial inflor...

A synopsis of the African genus Lipotriche (Compositae: Heliantheae: Ecliptinae)
submitted by mozinrhl 32 minutes ago - Topic: Biology
A synopsis of Lipotriche R. Br. (Compositae: Heliantheae: Ecliptinae) is provided, giving full synonymy, type citations and the location of known types, together with relevant notes and commentary, and the known distribution of each taxon. Twelve species are recognised, including five infraspecific taxa (including the relevant autonyms); ten new combinations are proposed in the genus, eight at ...