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Multiscale fingerprinting of neuronal functional connectivity
submitted by harndag 19 minutes ago - Topic: Health
Current cellular-based connectomics approaches aim to delineate the functional or structural organizations of mammalian brain circuits through neuronal activity mapping and/or axonal tracing. To discern possible connectivity between functionally identified neurons in widely distributed brain circuits, reliable and efficient network-based approaches of cross-registering or cross-correlating such...



Magnified effects of the COMT gene on white-matter microstructure in very old age
submitted by harndag 19 minutes ago - Topic: Health
Genetic factors may partly account for between-person differences in brain integrity in old age. Evidence from human and animal studies suggests that the dopaminergic system is implicated in the modulation of white-matter integrity. We investigated whether a genetic variation in the Catechol-O-Methyltransferase (COMT) Val158Met polymorphism, which influences dopamine availability in prefrontal ...

Spatial distribution of neurons innervated by chandelier cells
submitted by harndag 20 minutes ago - Topic: Health
Chandelier (or axo-axonic) cells are a distinct group of GABAergic interneurons that innervate the axon initial segments of pyramidal cells and are thus thought to have an important role in controlling the activity of cortical circuits. To examine the circuit connectivity of chandelier cells (ChCs), we made use of a genetic targeting strategy to label neocortical ChCs in upper layers of juvenil...

A predictive model of the cat cortical connectome based on cytoarchitecture and distance
submitted by harndag 20 minutes ago - Topic: Health
Information processing in the brain is strongly constrained by anatomical connectivity. However, the principles governing the organization of corticocortical connections remain elusive. Here, we tested three models of relationships between the organization of cortical structure and features of connections linking 49 areas of the cat cerebral cortex. Factors taken into account were relative cyto...

Hallucinations et trouble de personnalité borderline : une revue de littérature
submitted by ondribi889 43 minutes ago - Topic: Health
La présence d’hallucinations chez les patients présentant un trouble de personnalité borderline (TPB) est un phénomène encore peu étudié, souvent problématique en pratique clinique. Pourtant des hallucinations, essentiellement acoustico-verbales, sont retrouvées chez environ 30 % des patients atteints de TPB. La plupart sont transitoires, déclenchées par des situations de stress, ...



Role of Cognitive Enhancer Therapy in Alzheimer’s Disease with Concomitant Cerebral White Matter Disease: Findings from a Long-Term Naturalistic Study
submitted by osebliy 45 minutes ago - Topic: Health
Evidence is lacking for cognitive enhancer therapy in patients with Alzheimer’s disease (AD) and concomitant cerebrovascular disease (mixed AD) as such patients would have been excluded from clinical trials. Earlier studies of mixed AD have focused on large vessel cerebrovascular disease. The influence of small vessel cerebrovascular disease (svCVD) in the form of white matter hyperintensity ...

Generation of nonhydrolyzable ubiquitin–histone mimics
submitted by jeddocattan 53 minutes ago - Topic: Biology
Histone proteins undergo various types of post-translational modifications (PTMs) to regulate dynamic processes in the cell, including replication, transcription and DNA damage repair. One type of histone PTM is the attachment of a small protein, ubiquitin (Ub). In eukaryotic organisms, a single Ub is attached to specific lysine residues of histones H2A and H2B in a modification that, unlike ma...


Online Diagnosis System: A webserver for analysis of Sanger sequencing-based genetic testing data
submitted by jeddocattan 53 minutes ago - Topic: Biology
Sanger sequencing is a well-established molecular technique for diagnosis of genetic diseases. In these tests, DNA sequencers produce vast amounts of data that need to be examined and annotated within a short period of time. To achieve this goal, an online bioinformatics platform that can automate the process is essential. However, to date, there is no such integrated bioinformatics platform av...

Matching metabolites and reactions in different metabolic networks
submitted by jeddocattan 53 minutes ago - Topic: Biology
Comparing and identifying matching metabolites, reactions, and compartments in genome-scale reconstructed metabolic networks can be difficult due to inconsistent naming in different networks. In this paper, we propose metabolite and reaction matching techniques for matching metabolites and reactions in a given metabolic network to metabolites and reactions in another metabolic network. We emplo...


Estimating the composition of species in metagenomes by clustering of next-generation read sequences
submitted by jeddocattan 53 minutes ago - Topic: Biology
Faster and cheaper sequencing technologies together with the ability to sequence uncultured microbes collected from any environment present us an opportunity to distill meaningful information from the millions of new genomic sequences from environmental samples, called metagenome. Contrary to conventional cultured microbes, however, the metagenomic data is extremely heterogeneous and noisy. The...

Occlusion précoce après court-circuit gastrique avec anse en Y
submitted by weji 1 hour ago - Topic: Health
Nous rapportons le cas d’une occlusion postopératoire précoce après court-circuit gastrique. Le signe radiologique à rechercher est une dilatation gastrique sur le scanner. Il s’agit d’une urgence chirurgicale. We report a case of early post-operative intestinal obstruction after gastric bypass. The most frequent radiologic presentation is one of gastric dilatation on the CT scan. It ...


Botulinum toxin therapy of cervical dystonia: duration of therapeutic effects
submitted by edihioran 1 hour ago - Topic: Health
We sought to explore the therapeutic effect of botulinum toxin (BT) therapy by analysing the time between the BT application and the onset of its decrease (treatment duration, TD), the inter-injection interval (II), and the excess time (ET, ET = II-TD). For this we studied 59 patients (37 females, 22 males, age 52.6 ± 10.9 years) with cervical dystonia (CD, Tsui score 9.0 ± 4.1) and BT...

Cerebrospinal fluid and plasma C-reactive protein and aggression in personality-disordered subjects: a pilot study
submitted by edihioran 1 hour ago - Topic: Health
C-reactive protein (CRP), in the plasma, serves as a marker of systemic inflammation and has been shown to correlate with history of actual aggressive behavior, and as a personality trait of aggressive tendency, in human subjects. This pilot study was conducted to determine if plasma CRP levels are correlated with cerebrospinal fluid levels (CSF CRP) and if CSF CRP also correlates with aggressi...

Elucidating the neurophysiological underpinnings of autism spectrum disorder: new developments
submitted by edihioran 1 hour ago - Topic: Health
The study of neurophysiological approaches together with rare and common risk factors for Autism Spectrum Disorder (ASD) allows elucidating the specific underlying neurobiology of ASD. Whereas most neurophysiologically based research in ASD to date has focussed on case–control differences based on the DSM- or ICD-based categorical ASD diagnosis, more recent studies have aimed at studying gene...

Electrophysiological characteristics of task-specific tremor in 22 instrumentalists
submitted by edihioran 1 hour ago - Topic: Health
Our aim was to address three characteristics of task-specific tremor in musicians (TSTM): First, we quantified muscular activity of flexor and extensor muscles, of coactivation as well as tremor acceleration. Second, we compared muscular activity between task-dependent and position-dependent tremor. Third, we investigated, whether there is an overflow of muscular activity to muscles adjacent ...