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Water-extractable organic matter and enzyme activity in three forest soils of the Mediterranean area
submitted by moty 27 minutes ago - Topic: Biology
Soil enzyme activities mediate key ecosystem functions of degradation, transformation and carbon mineralization. The study of microbial activity and its relations with water-extractable organic matter (WEOM) can be crucial to understand the dynamics of soil organic carbon pool. We investigated FDA-hydrolytic, β-glucosidase, cellulase, o-diphenol oxidase activities in soils under Fagus sylvatic...



Soil microbial community structure and activity along a montane elevational gradient on the Tibetan Plateau
submitted by moty 27 minutes ago - Topic: Biology
Knowledge about the distribution pattern and function of soil microbial communities is essential for understanding their vital role in ecosystem functioning. However, little is known about the elevational patterns of microbial communities at high altitudes on the Tibetan Plateau, a region that is very sensitive to global change. We investigated the microbial community composition and functional...

Performance of different wheat genotypes inoculated with the plant growth promoting bacterium Herbaspirillum seropedicae
submitted by moty 27 minutes ago - Topic: Biology
Several diazotrophic bacteria can promote plant growth and increase crop productivity. However, such effects are variable probably due to interaction between the plant genotype and the bacterial strain, soil properties and climatic factors. The aim of this study was to evaluate the performance of wheat genotypes inoculated with Herbaspirillum seropedicae SmR1, an endophytic diazotrophic bacteri...

First Trimester Vitamin D Status and Placental Epigenomics in Preeclampsia Among Northern Plains Primiparas
submitted by komemoy6 29 minutes ago - Topic: Biology
As maternal vitamin D status has been associated with preeclampsia, the purpose of this study was to determine variations in DNA methylation patterns and associated protein expression in placental genes regulating vitamin D metabolism. A convenience sample of 48 pregnant nulliparous women, including 11 later diagnosed with preeclampsia, were recruited in this prospective study. Using a case-con...

Endogenous ACh suppresses LTD induction and nicotine relieves the suppression via different nicotinic ACh receptor subtypes in the mouse hippocampus
submitted by komemoy6 29 minutes ago - Topic: Biology
Studying the normal role of nicotinic cholinergic systems in hippocampal synaptic plasticity is critical for understanding how cholinergic loss in Alzheimer’s disease (AD) and tobacco use affect cognitive function. However, it is largely unknown how nicotinic cholinergic systems regulate the induction of long-term depression (LTD). Extracellular field potential recordings were performed in hi...



Rosmarinic acid mediated neuroprotective effects against H2O2-induced neuronal cell damage in N2A Cells
submitted by komemoy6 29 minutes ago - Topic: Biology
Oxidative stress plays a key role in several ailments including neurodegenerative conditions. The aim of the study was to demonstrate the effect of rosmarinic acid (RA) in preventing oxidative stress related death of neuronal cell lines. In the present study, we demonstrated direct neuroprotective effect of RA using H2O2-induced oxidative challenge in N2A mouse neuroblastoma cells. The mechanis...

CKD712, a synthetic isoquinoline alkaloid, enhances anti-cancer effects of paclitaxel in MDA-MB-231 cells through regulation of PTEN
submitted by komemoy6 29 minutes ago - Topic: Biology
It has been reported that in human glioblastoma cells, a phosphotase and tensin homolog (PTEN) positive cells are more prone to paclitaxel-induced apoptosis than PTEN-negative cells. We investigated whether (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) enhances the therapeutic effects of paclitaxel (including effects on cellular proliferation, invasion and apop...


Mitochondrial dysfunction and oxidative damage in the brain of diet-induced obese rats but not in diet resistant rats
submitted by komemoy6 29 minutes ago - Topic: Biology
It has been suggested that obesity triggered by consuming a high-fat diet (HF) can account for oxidative damage and mitochondrial dysfunction. Thus, we aim to explore the oxidative stress and mitochondrial dysfunction detected in the brain of diet-induced obese (DIO) rats. Sprague-Dawley (SD) rats were fed either a HF diet or normal-fat (NF) diet for 10weeks to obtain the control (CON), DIO and...

Hydrogen peroxide inhibits proliferation and endothelial differentiation of bone marrow stem cells partially via reactive oxygen species generation
submitted by komemoy6 29 minutes ago - Topic: Biology
The present study was to investigate the effect of hydrogen peroxide (H2O2 ) on bone marrow stem cells and their endothelial differentiation and the underlying mechanisms in vitro. Rat bone marrow multipotent adult progenitor cells (MAPCs) were used as the source of bone marrow stem cells, and treated with H2O2 (with the final concentration from 0 to 50μM) with or without N-acetylcysteine (NAC...


Dietary heat-killed Lactobacillus brevis SBC8803 promotes voluntary wheel-running and affects sleep rhythms in mice
submitted by komemoy6 30 minutes ago - Topic: Biology
We previously reported that heat-killed Lactobacillus brevis SBC8803 enhances appetite via changes in autonomic neurotransmission. Here we assessed whether a diet supplemented with heat-killed SBC8803 affects circadian locomotor rhythmicity and sleep architecture. Daily total activity gradually increased in mice over four weeks and supplementation with heat-killed SBC8803 significantly intensif...

Using high resolution imaging to determine trafficking of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleus
submitted by komemoy6 30 minutes ago - Topic: Biology
Trafficking of G protein-coupled receptors (GPCRs) is a critical determinant of cellular sensitivity of neurons. To understand how endogenous or exogenous ligands impact cell surface expression of GPCRs, it is essential to employ approaches that achieve superior anatomical resolution at the synaptic level. In situations in which light and fluorescence microscopy techniques may provide only limi...


Stigma and Mental Health Treatment of Adolescents with Depression in Jordan
submitted by takwefe37 33 minutes ago - Topic: Health
Stigma is a fundamental barrier to seeking and engaging in mental health treatment for individuals managing depression. This study examines stigma perceptions of mental health treatment for Arab adolescents managing depression using a vignette survey completed by adults in public spaces in Amman, Jordan (n = 108). The vignette was systematically changed across four different conditions that ...

High School Dropouts in Emerging Adulthood: Substance Use, Mental Health Problems, and Crime
submitted by takwefe37 33 minutes ago - Topic: Health
This study examined the distribution of substance use, mental health, and criminal behavior among dropouts derived from a nationally representative sample of 18–25 year old (N = 19,312) emerging adults in the United States. Using public-use data from the 2010 National Survey on Drug Use and Health, this study employed multiple logistic regression with adjustments for complex survey samplin...

Exploring the Experiences of Client Involvement in Medication Decisions Using a Shared Decision Making Model: Results of a Qualitative Study
submitted by takwefe37 33 minutes ago - Topic: Health
This qualitative study explored a newly introduced model of shared decision making (CommonGround) and how psychiatric medications were experienced by clients, prescribers, case managers and peer support staff. Of the twelve client subjects, six were highly engaged in shared decision-making and six were not. Five notable differences were found between the two groups including the presence of a g...

Lymphoprolifération systémique T liée à l’EBV chez l’enfant
submitted by kamada3k8 39 minutes ago - Topic: Health
La lymphoprolifération systémique T liée à l’Epstein-Barr virus (EBV) est une entité récente décrite dans la classification de l’OMS 2008 comme une lymphoprolifération systémique clonale de lymphocytes T infectés par l’EBV. Elle survient après une infection aiguë ou chronique active à EBV. Nous rapportons l’observation d’une enfant de 12ans, d’origine caucasienne, immu...