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Leptospiral Pathogenomics
submitted by 10 minutes ago - Topic: Health
Leptospirosis, caused by pathogenic spirochetes belonging to the genus Leptospira, is a zoonosis with important impacts on human and animal health worldwide. Research on the mechanisms of Leptospira pathogenesis has been hindered due to slow growth of infectious strains, poor transformability, and a paucity of genetic tools. As a result of second generation sequencing technologies, there has be...



Pseudomonas aeruginosa Genome Evolution in Patients and under the Hospital Environment
submitted by 11 minutes ago - Topic: Health
Pseudomonas aeruginosa is a Gram-negative environmental species and an opportunistic microorganism, establishing itself in vulnerable patients, such as those with cystic fibrosis (CF) or those hospitalized in intensive care units (ICU). It has become a major cause of nosocomial infections worldwide and a serious threat to Public Health because of overuse and misuse of antibiotics that have sele...

Application of DNA Aptamers and Quantum Dots to Lateral Flow Test Strips for Detection of Foodborne Pathogens with Improved Sensitivity versus Colloidal Gold
submitted by 11 minutes ago - Topic: Health
Preliminary studies aimed at improving the sensitivity of foodborne pathogen detection via lateral flow (LF) test strips by use of high affinity DNA aptamers for capture and reporter functions when coupled to red-emitting quantum dots (Qdot 655) are reported. A variety of DNA aptamers developed against Escherichia coli, Listeria monocytogenes, and Salmonella enterica were paired in capture and ...

Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway
submitted by 14 minutes ago - Topic: Biology
Signaling through vascular endothelial growth factor C (VEGF-C) and VEGF receptor 3 (VEGFR-3) plays a central role in lymphangiogenesis and the metastasis of several cancers via the lymphatics. Recently, the Slit2/Robo4 pathway has been recognized as a modulator of vascular permeability and integrity. Signaling via the Robo receptor inhibits VEGF-mediated effects; however, its effects on lympha...

Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhance their angiogenic potential
submitted by 14 minutes ago - Topic: Biology
Several studies demonstrate the role of adipose mesenchymal stem cells (ASCs) in angiogenesis. The angiogenic mechanism has been ascribed to paracrine factors since these cells secrete a plenty of signal molecules and growth factors. Recently it has been suggested that besides soluble factors, extracellular vesicles (EVs) that include exosomes and microvesicles may play a major role in cell-to-...



Signaling by epithelial members of the CEACAM family - mucosal docking sites for pathogenic bacteria
submitted by 15 minutes ago - Topic: Biology
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) comprise a group of immunoglobulin-related vertebrate glycoproteins. Several family members, including CEACAM1, CEA, and CEACAM6, are found on epithelial tissues throughout the human body. As they modulate diverse cellular functions, their signaling capacity is in the focus of current research. In this review we will summarize t...

Autoinhibition of the Ron Receptor Tyrosine Kinase by the Juxtamembrane Domain
submitted by 15 minutes ago - Topic: Biology
The Ron receptor tyrosine kinase (RTK) has been implicated in the progression of a number of carcinomas, thus understanding the regulatory mechanisms governing its activity is of potential therapeutic significance. A critical role for the juxtamembrane domain in regulating RTK activity is emerging, however the mechanism by which this regulation occurs varies considerably from receptor to recept...


SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis
submitted by 16 minutes ago - Topic: Health
Identification of variants within genes SLC23A1 and SLC23A2 coding for vitamin C transporter proteins associated with aggressive (AgP) and chronic periodontitis (CP). Employment of three independent case-control samples of AgP (I. 283 cases, 979 controls; II. 417 cases, 1,912 controls; III. 164 cases, 357 controls) and one sample of CP (1,359 cases, 1,296 controls). Stage 1: Among the tested SN...

Periodontal pathogens and associated factors in aggressive periodontitis: results 5-17 years after active periodontal therapy
submitted by 16 minutes ago - Topic: Health
To assess the association between presence of periodontal pathogens and recurrence of disease in patients with aggressive periodontitis (AgP) after active periodontal therapy (APT) and further influencing factors. Material and MethodsMicrobiological samples were taken from 73 patients with AgP 5-17 years after APT at 292 sites (deepest site per quadrant). Real-time polymerase chain reactions we...


An RCT comparing patient-centered outcome variables of guided surgery (bone or mucosa supported) with conventional implant placement
submitted by 16 minutes ago - Topic: Health
To assess in a randomized study the patient-centered outcome of two guided surgery systems (mucosa or bone supported) compared to conventional implant placement, in fully edentulous patients. Material and MethodsFifty-nine patients (72 jaws) with edentulous maxillas and/ or mandibles, were consecutively recruited and randomly assigned to one of the treatment groups. Outcome measures were the Du...

Growth/Differentiation Factor-5 (GDF-5): Preclinical and Clinical Evaluations of Periodontal Regeneration and Alveolar Augmentation. Review
submitted by 17 minutes ago - Topic: Health
Growth/differentiation factor-5 (GDF-5) plays critical roles in mesenchymal cell differentiation and stimulates human periodontal ligament cell proliferation. Potentially, GDF-5 may also play roles in wound healing including periodontal regeneration and alveolar augmentation. The objective of this review is to provide up-to-date information from preclinical/clinical studies evaluating GDF-5 for...


Surgical Periodontal Therapy with and without Initial Scaling and Root Planing in the Management of Chronic Periodontitis
submitted by 17 minutes ago - Topic: Health
To compare the outcomes of surgical periodontal therapy with and without initial scaling and root planing. Twenty-four patients with severe chronic periodontitis were enrolled in this pilot, randomized controlled clinical trial. Patients were equally allocated into 2 treatment groups: Control group was treated with scaling and root planing, re-evaluation, followed by Modified Widman Flap surger...

Quantitative Gingival Crevicular Fluid Proteome in Health and Periodontal Disease Using Stable-Isotope Chemistries and Mass Spectrometry
submitted by 17 minutes ago - Topic: Health
Application of quantitative stable-isotope-labeling chemistries and mass spectrometry (MS) to determine alterations in gingival crevicular fluid (GCF) proteome in periodontal disease. Quantitative proteome of GCF from 40 healthy individuals versus 40 patients with periodontal disease was established using 320 GCF samples and stable-isotope-labeling reagents, ICAT and mTRAQ, with MS technology a...

The Periodontal health component of the Renal Impairment In Secondary Care (RIISC) cohort study: A Description of the Rationale, Methodology and Initial Baseline Results
submitted by 17 minutes ago - Topic: Health
Chronic Kidney Disease (CKD) is associated with significant morbidity and mortality. There is a need to identify novel and modifiable risk factors in such patients. The periodontal component of the Renal Impairment In Secondary Care (RIISC) study aims to evaluate the association between chronic periodontitis and CKD progression. The RIISC study is a prospective, observational cohort study of pa...

Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2
submitted by 17 minutes ago - Topic: Health
To test the hypothesis that a synthetic HA/TCP construct combined with PEG hydrogel including rhBMP-2 enhances new bone formation compared with BMP-2 delivered using the HA/TCP construct alone. Material and MethodsBilateral mandibular partial thickness 20 x 8 x 8 mm (L x W x H) alveolar defects were surgically created in the edentulated posterior mandible in 18 female minipigs. Randomized into ...

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