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Students 4 Best Evidence: a new way of engaging the younger generation in evidence-based health care
submitted by ntgrzych 6 minutes ago - Topic: Health
In March 2013, Sir Muir Gray stood up at the Cochrane UK & Ireland Anniversary Symposium Gala Dinner and asked everyone under the age of 40 to stand up and be toasted by everyone in the room over 40 years. He sought to recognise not only future generations of Cochrane contributors but also the future stakeholders for evidence-based health care, in general, the health professionals, policyma...



New Technologies in COPD Management
submitted by rechisib 6 minutes ago - Topic: Health
Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating disease that affects millions of Americans. Numerous technological advances have been made recently in this field. This article reviews the use of novel technologies in COPD patients, focusing on the medical literature from 2013. These advances affect the diagnosis, the management of acute exacerbations, and the long...

Estratificación de la población mayor de 65 años en grupos de riesgo clínico: características y valoración enfermera
submitted by samonothco 9 minutes ago - Topic: Health
Analizar las características de la población mayor de 65 años atendida en un Área Básica de Salud según la clasificación de Clinical Risk Groups (CRG, «Grupos de Riesgo Clínico») y la valoración de los test geriátricos realizados por la enfermera en relación con la complejidad que presentan. Estudio observacional, descriptivo transversal, realizado sobre la población mayor de 65 a...

Motivación para cambiar estilos de vida no saludables y riesgo cardiovascular
submitted by samonothco 9 minutes ago - Topic: Health
Estudiar la relación entre motivación para cambiar estilos de vida no saludables y riesgo cardiovascular. Estudio transversal, aleatorizado, estratificado por edad, realizado en el ámbito de la atención primaria con una muestra de 369 personas. Se consideró fumador aquel con consumo activo o en deshabituación inferior al año, el hábito físico se valoró en actividad laboral y de ocio, ...

Nephrotic Syndrome Secondary to Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits of Lambda Light Chain
submitted by phainex 10 minutes ago - Topic: Health
We describe a rare case of a 46-year-old woman with history of refractory nephrotic syndrome and hypertension who presented with worsening proteinuria and kidney function. Work-up for both autoimmune and infectious diseases and hematologic malignancies including multiple myeloma were negative. Kidney biopsy demonstrated glomerular sclerotic change with lambda light chain deposits in the subendo...



Fever of unknown origin in a young man
submitted by diltovit 10 minutes ago - Topic: Health
Sphingomonas paucimobilis bacteraemia is a rare infection typically related to nosocomial outbreaks. A 33-year-old immunocompetent man requested evaluation in the Internal Medicine Department for fever without source. His physical examination was normal. Laboratory analysis showed mild hypertransaminasemia. In both blood culture sets grew Gram-negative bacilli, being identified as S. paucimobil...

Overexpression of MTA1 promotes invasiveness and metastasis of ovarian cancer cells
submitted by diltovit 10 minutes ago - Topic: Health
To investigate the effect of metastasis-associated gene MTA1 on proliferation and invasion potential of ovarian cancer cell line A2780. The eukaryotic expressing vector pcDNA3. 1-MTA1 was introduced into A2780 cells by gene transfection in vitro. The MTA1 mRNA and protein level in cancer cells were detected by reverse transcription polymerase chain reaction (RT-PCR) and western blot, respective...


Pre-pregnancy care and pregnancy outcomes in type 1 diabetes mellitus: a comparison of continuous subcutaneous insulin infusion and multiple daily injection therapy
submitted by diltovit 10 minutes ago - Topic: Health
Pre-pregnancy care improves pregnancy outcomes in type 1 diabetes mellitus (T1DM). Continuous subcutaneous insulin infusion (CSII) therapy and multiple daily injection (MDI) therapy can both be used to achieve glycaemic targets, but few data are available to compare their efficacy in pre-pregnancy care. To compare MDI and CSII in pre-pregnancy care in T1DM. Retrospective database review of wome...

Risk factors for hospital-acquired bloodstream infections caused by extended-spectrum β-lactamase Klebsiella pneumoniae among cancer patients
submitted by diltovit 10 minutes ago - Topic: Health
Incidence of infection due to extended-spectrum β-lactamase producing Klebsiella pneumoniae (ESBL-KP) has increased rapidly in recent years. However, its prevalence in cancer patients is seldom reported. This study was designed to identify the risk factors for bloodstream infections (BSIs) with ESBL-KP, and to understand its susceptibility among cancer patients on antibiotics. We conducted a r...


Effects of sildenafil treatment on patients with Peyronie’s disease and erectile dysfunction
submitted by diltovit 10 minutes ago - Topic: Health
It has been shown on experimental rat models that type 5-phosphodiesterase isoenzyme (PDE5) inhibitors have anti-fibrotic effects for Peyronie’s disease (PD); however, this issue has not been addressed clinically. The aim of this study was to document the effects of PDE5 inhibitors used for erectile dysfunction (ED) seen in PD patients on the main course of the PD clinically. A total of 39 PD...

Readability and content of patient information leaflets for endoscopic procedures
submitted by diltovit 11 minutes ago - Topic: Health
Informed consent requires good communication. Patient information leaflets (PILs) may be helpful, although some PILs are too hard to read for the average patient. We sought to examine the readability of PILs provided for patients prior to endoscopic procedures in 24 gastrointestinal and 16 respiratory departments of 24 Irish public hospitals. Readability, measured using the Flesch Reading Ease ...


The effect of age on positional differences in anthropometry, body composition, physique and anaerobic power of elite basketball players
submitted by podgelworsogor 11 minutes ago - Topic: Health
The main aim of this study was to examine differences in physical and physiological characteristics, with an emphasis on anaerobic power, of male basketball players by age and playing position. Basketball players (n = 101), classified into three age groups: under 15 years (U-15, n = 35, 14.28 ± 0.72 years), under 18 years (U-18, n = 35, 16.23 ± 0.74 years) and older than 18 yea...

Co-culture of bone marrow-derived mesenchymal stem cells overexpressing lipocalin 2 with HK-2 and HEK293 cells protects the kidney cells against cisplatin-induced injury
submitted by dorodero 14 minutes ago - Topic: Biology
Conditioned medium of mesenchymal stem cells (MSCs) is now being used for its cytoprotective effects, especially when the cells are equipped with cytoprotective factors to strengthen them against unfavorable microenvironments. Overexpression of Lcn2 in MSCs mimics in vivo kidney injury. Hence, unraveling how Lcn2-engineered MSCs affect kidney cells has been investigated. Cisplatin treated HK-2 ...

IL-1β microenvironment promotes proliferation, migration, and invasion of human glioma cells
submitted by dorodero 14 minutes ago - Topic: Biology
Among the primary brain tumors, glioblastoma is the most common and severe. Glioblastoma have poor prognosis because of their highly diffusive growth pattern and invasion into surrounding brain tissue. Human glioblastoma cells overexpress interleukin-1β (IL-1β) and also the levels of IL-1β in U87MG glioma cells are significantly higher than in U373, T98G, A172 glioma cell lines. Malignant tu...

Melanocyte migration is influenced by E-cadherin-dependent adhesion of keratinocytes in both two- and three- dimensional in vitro wound models
submitted by dorodero 14 minutes ago - Topic: Biology
During wound healing, melanocytes are required to migrate into the wounded area that is still in the process of re-construction. The role and behaviour of melanocytes during this process is poorly understood, that is, whether melanocyte migration into the wound is keratinocyte-dependent or not. This paper attempts, through the use of both two- and three-dimensional in vitro models, to understan...