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Non-Pharmaceutical Approaches to Pain Management
submitted by 12 minutes ago - Topic: Biology
A non-pharmaceutical approach to managing pain is one that does not employ a medication. The use of such approaches, in conjunction with pharmaceuticals as part of multi-modal methods to managing pain, is becoming more popular as evidence is emerging to support their use. Cold therapy, for one, is utilized to reduce the inflammation and tissue damage seen in acute injuries and can be very effec...



Proposed Treatment for Geriatric Vestibular Disease in Dogs
submitted by 12 minutes ago - Topic: Biology
Sudden onset vestibular dysfunction in the canine is a commonly seen condition in veterinary practice, with some veterinarians reporting several cases each month. However, traditional veterinary medicine has little to offer these patients other that symptomatic relief for the severe nausea that accompanies the vertigo and supportive advice for the owners. Owners of affected dogs are informed th...

Acupuncture for Analgesia in Veterinary Medicine
submitted by 12 minutes ago - Topic: Biology
Acupuncture for analgesia is growing rapidly in popularity with veterinarians and pet owners. This paper summarizes the mechanisms of analgesia derived from acupuncture and reviews current literature on the topic. Areas covered include the local effects at area of needle insertion, systemic effects secondary to circulating neurotransmitters and changes in cell signaling, central nervous system ...

Opening Clinical Encounters in an Adult Musculoskeletal Setting
submitted by 12 minutes ago - Topic: Health
Effective communication between healthcare professionals and their patients is crucial for successful consultations, and can profoundly affect patients’ adherence to treatment. Despite this evidence, communication within the physiotherapy profession is still underexplored, in particular, how ‘best’ to open clinical encounters. This study explores the issue by seeking the preferences of ph...

Manual therapy directed at the knee or lumbopelvic region does not influence quadriceps spinal reflex excitability
submitted by 12 minutes ago - Topic: Health
Manual therapies, directed to the knee and lumbopelvic region, have demonstrated the ability to improve neuromuscular quadriceps function in individuals with knee pathology. It remains unknown if manual therapies may alter impaired spinal reflex excitability, thus identifying a potential mechanism in which manual therapy may improve neuromuscular function following knee injury. To determine the...



The Effects Of Spinal Mobilizations On The Sympathetic Nervous System: A Systematic Review
submitted by 12 minutes ago - Topic: Health
The activity of the sympathetic nervous system is of importance to manual therapists, since the experience of pain is associated with sympathetic activity. There has been little exploration into the effects of mobilizing vertebral segments below the cervical spine. In addition to this, a synthesis of the evidence for changes in sympathetic outcome measures has not been completed. The primary ai...

Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH1–34) for skeletal repair
submitted by 15 minutes ago - Topic: Biology
Teriparatide (PTH1–34) promotes skeletal repair and increases bone mass. Vitamin K is involved in bone mineralization as a coenzyme of γ-carboxylase for Gla proteins, and therefore vitamin K insufficiency caused by malnutrition or therapeutic intake of the vitamin K antagonist warfarin could affect the efficacy of PTH1–34 therapy for bone repair. In the present study, we investigated wheth...


Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period
submitted by 15 minutes ago - Topic: Biology
Rankl is a key regulator of bone resorption and osteoclastogenesis. Denosumab is a fully human IgG2 monoclonal antibody that inhibits bone resorption by binding and inhibiting the activity of rankl. To determine the effects of denosumab on pre- and postnatal skeletal growth and development, subcutaneous injections of 0 (control) or 50mg/kg/month denosumab were given to pregnant cynomolgus monke...

Novel homozygous inactivating mutation of the calcium-sensing receptor gene (CASR) in neonatal severe hyperparathyroidism – lack of effect of cinacalcet
submitted by 15 minutes ago - Topic: Biology
Nshpt is a life threatening disorder caused by homozygous inactivating calcium-sensing receptor (CASR) mutations. In some cases, the CaSR allosteric activator, cinacalcet, may reduce serum PTH and calcium levels, but surgery is the treatment of choice. To describe a case of nshpt unresponsive to cinacalcet. A 23-day-old girl was admitted with hypercalcaemia, hypotonia, bell-shaped chest and res...


The effects of once-weekly teriparatide on hip geometry assessed by hip structural analysis in postmenopausal osteoporotic women with high fracture risk
submitted by 15 minutes ago - Topic: Biology
Weekly administration of teriparatide has been shown to reduce the risk of vertebral and non-vertebral fractures in patients with osteoporosis at higher fracture risk in Japan. However, its efficacy for hip fracture has not been established. To gain insight into the effect of weekly teriparatide on the hip, hip structural analysis (HSA) based on dual-energy X-ray absorptiometry (DXA) was perfor...

Analysis of strength and failure pattern of human proximal femur using quantitative computed tomography (QCT)-based finite element method
submitted by 15 minutes ago - Topic: Biology
This paper presents a novel method for fast and reliable prediction of the failure strength of human proximal femur, using the quantitative computed tomography (QCT)-based linear finite element analysis (FEA). Ten fresh frozen human femora (age: 34±16) were QCT-scanned and the pertinent 3D voxel-based finite element models were constructed. A specially-designed holding frame was used to define...


A novel calcium supplement prepared by phytoferritin nanocages protects against absorption inhibitors through a unique pathway
submitted by 15 minutes ago - Topic: Biology
The consumption of milk is declining in industrialized countries, leading to inadequate calcium intake. Therefore, it is important to explore a new class of Ca-enriched nutrient for the fortification of food. In this work, we prepared a novel class of soluble and edible Ca-protein complexes where approximately 140 calcium ions were encapsulated within phytoferritin nanocage. As an alternative t...

Effect of combined teriparatide and monthly minodronic acid therapy on cancellous bone mass in ovariectomized rats: A bone histomorphometry study
submitted by 15 minutes ago - Topic: Biology
The purpose of the present study was to determine whether teriparatide and monthly minodronic acid would have an additive effect on cancellous bone mass in ovariectomized rats. Seven-week-old female Sprague–Dawley rats were randomized into five groups of 10 animals each, including a sham-operation+vehicle group, an ovariectomy (OVX)+vehicle group, an OVX+minodronic acid (6μg/kgs.c., every 4w...

Quantitative trait loci that modulate trabecular bone's risk of failure during unloading and reloading
submitted by 18 minutes ago - Topic: Biology
Genetic makeup of an individual is a strong determinant of the morphologic and mechanical properties of bone. Here, in an effort to identify quantitative trait loci (QTLs) for changes in the simulated mechanical parameters of trabecular bone during altered mechanical demand, we subjected 352second generation female adult (16weeks old) BALBxC3H mice to 3weeks of hindlimb unloading followed by 3w...

Peripheral quantitative computed tomography measures are associated with adult fracture risk: The Hertfordshire Cohort Study
submitted by 18 minutes ago - Topic: Biology
Peripheral quantitative computed tomography (pQCT) captures novel aspects of bone geometry that may contribute to fracture risk and offers the ability to measure both volumetric bone mineral density (vBMD) and a separation of trabecular and cortical compartments of bone, but longitudinal data relating measures obtained from this technique to incident fractures are lacking. Here we report an ana...

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