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The protein-sparing modified fast for obese patients with type 2 diabetes: What to expect
submitted by colthrapi 27 minutes ago - Topic: Health
The protein-sparing modified fast (PSMF) is a very-low-calorie diet containing mostly protein and little carbohydrate. This article reviews the principles of the PSMF and its potential benefits in terms of weight loss, glycemic control, insulin resistance, cardiovascular risk factors, and related complications for patients with type 2 diabetes.

Radon and lung cancer: Assessing and mitigating the risk
submitted by colthrapi 27 minutes ago - Topic: Health
Radon is a naturally occurring radioactive gas. Its progenies emit alpha particles capable of causing tissue damage. Radon exposure is estimated to be the second most common cause of lung cancer in the United States. Management of patients with a history of radon exposure should involve a lung cancer specialist.

Hand, foot, and mouth disease: Identifying and managing an acute viral syndrome
submitted by colthrapi 27 minutes ago - Topic: Health
Hand, foot, and mouth disease (HFMD) is a common, typically self-limited viral syndrome in children and adults. It is marked by fever, oral ulcers, and skin manifestations affecting the palms, soles, and buttocks, with symptoms usually lasting less than 1 week. Because it has the potential to reach epidemic levels in the United States, general practitioners need to be aware of it.

Limited role for ASC and NLRP3 during in vivo Salmonella Typhimurium infection
submitted by oblfobl 28 minutes ago - Topic: Health
The inflammasome is an intracellular protein complex triggered by exposure to intracellular pathogens, its components or other endogenous proteins. It leads to the activation of and subsequent release of proinflammatory cytokines such as IL-1β and IL-18. S. Typhimurium is a Gram-negative intracellular bacterium, which is known to trigger inflammasome assembly via recognition by the cytosolic r...

Simple amino acid tags improve both expression and secretion of Candida antarctica lipase B in recombinant Escherichia coli
submitted by orreboso 34 minutes ago - Topic: Biology
Escherichia coli is the best-established microbial host strain for production of proteins and chemicals, but has a weakness for not secreting high amounts of active heterologous proteins to the extracellular culture medium, of which origins belong to whether prokaryotes or eukaryotes. In this study, Candida antarctica lipase B (CalB), a popular eukaryotic enzyme which catalyzes a number of bioc...

Poloxamer surfactant preserves cell viability during photoacoustic delivery of molecules into cells
submitted by orreboso 34 minutes ago - Topic: Biology
Efficient intracellular delivery of molecules is needed to modulate cellular behavior for laboratory and medical applications, but is often limited by trade-offs between achieving high intracellular delivery and maintaining high cell viability. Here, we studied photoacoustic delivery of molecules into cells by exposing DU145 human prostrate carcinoma cells to nanosecond laser pulses in the pres...

RPN2 Gene Confers Osteosarcoma Cell Malignant Phenotypes and Determines Clinical Prognosis
submitted by mpeipir 38 minutes ago - Topic: Health
Drug resistance and metastasis are lethal characteristics of tumors. We previously demonstrated that silencing of ribophorin II (RPN2), which is part of the N-oligosaccharyl transferase complex, efficiently induced apoptosis and reduced resistance to docetaxel in human breast cancer cells. Here, we report the clinical and functional correlations of RPN2 expression in osteosarcoma. Immunohistoch...

Probabilistic Bidirectional Promoter Switches: Noncoding RNA Takes Control
submitted by mpeipir 38 minutes ago - Topic: Health
The discovery of probabilistic promoter switches in genes that code for class I major histocompatibility complex receptors in mouse and human provides a useful paradigm to explain programmed cell fate decisions. These switches have preset probabilities of transcribing in either the sense or antisense direction, and the characteristics of individual switches are programmed by the relative affini...

Chopping off the chondrocyte proteome
submitted by mateishori 38 minutes ago - Topic: Biology
The progressive nature of osteoarthritis is manifested by the dynamic increase of degenerated articular cartilage, which is one of the major characteristics of this debilitating disease. As articular chondrocytes become exposed to inflammatory stress they enter a pro-catabolic state, which leads to the secretion and activation of a plethora of proteases. In aim to detect the disease before mass...

Stillbirth rates among indigenous and non-indigenous women in Queensland, Australia: is the gap closing?
submitted by jisascall 41 minutes ago - Topic: Health
To determine whether the disparity gap is closing between stillbirth rates for indigenous and non-indigenous women and to identify focal areas for future prevention efforts according to gestational age and geographic location. Population-based retrospective cohort study. Queensland, Australia. PopulationAll singleton births of at least 20 weeks of gestation or at least 400 g birthweight. Rout...

Angiopep-2-conjugated liposomes encapsulating γ-secretase inhibitor for targeting glioblastoma stem cells
submitted by sommei 41 minutes ago - Topic: Health
CD133+ cell subpopulation in U87 MG cells displays glioblastoma stem cell (GSC) like properties. Notch, a key regulator of stem cells, is also over-activated in GSCs. It was previously reported that γ-secretase inhibitors inhibit the Notch pathway by targeting the γ-secretase complex. To examine the GSCs, CD133+ cells were separated from the U87 MG cells by magnetic activated cell sorting and...

Ado-trastuzumab emtansine (T-DM1) in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer: latest evidence and clinical potential
submitted by eyoda86 42 minutes ago - Topic: Health
In February 2013, ado-trastuzumab emtansine (T-DM1, Kadcyla®) received regulatory approval in the United States for treatment-refractory human epidermal growth factor receptor 2 (HER2) positive metastatic or locally advanced breast cancer based on results from EMILIA, a large phase III trial that compared standard of care lapatinib plus capecitabine to T-DMSeveral other studies have been re...

Improving the link between payments and the provision of ecosystem services in agri-environment schemes
submitted by silsay74 43 minutes ago - Topic: Biology
This paper considers how agri-environment schemes under the Common Agricultural Policy could be adapted to derive a higher return of ecosystem services, by spatially targeting the services most valued by society and providing incentives for cross-boundary management of certain ecosystem services at catchment or wider spatial scales. The paper reviews evidence that spatially targeted, outcome-ba...

Valuing water quality improvements from peatland restoration: Evidence and challenges
submitted by silsay74 43 minutes ago - Topic: Biology
There is evidence that damaged peatlands can negatively affect the delivery of water related ecosystem services. There is interest in peatland restoration to meet different regulatory targets, including the Water Framework Directive (WFD). A comprehensive assessment of the economic benefits of restoration is missing. This paper synthesises hydrological and bio-geochemical knowledge on peatland ...

Relationships between anthropogenic pressures and ecosystem functions in UK blanket bogs: Linking process understanding to ecosystem service valuation
submitted by silsay74 43 minutes ago - Topic: Biology
Quantification and valuation of ecosystem services are critically dependent on the quality of underpinning science. While key ecological processes may be understood, translating this understanding into quantitative relationships suitable for use in an ecosystem services context remains challenging. Using blanket bogs as a case study, we derived quantitative ‘pressure-response functions’ lin...