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The need to define treatment goals for systemic lupus erythematosus
submitted by wf1321 9 minutes ago - Topic: Health
Active systemic lupus erythematosus (SLE) can manifest in heterogeneous clinical forms, making description of SLE clinical states difficult in patients with high disease activity. In this Opinion article, the authors argue the time has come to change the way SLE is managed by defining a treatment goal based on defining a low disease activity state, and they suggest possible inclusions in, and o...

Osteoarthritis: Does post-injury ACL reconstruction prevent future OA?
submitted by wf1321 9 minutes ago - Topic: Health
Young adults with an acute rupture of the anterior cruciate ligament of the knee are faced with the decision of whether or not to undergo early reconstructive surgery. However, a lack of high-quality evidence means questions remain about whether this surgical strategy protects against the development of osteoarthritis in the future.

Soluble MHC-II proteins promote suppressive activity in CD4+ T-cells
submitted by bdobolas 14 minutes ago - Topic: Health
Soluble MHC-II (sMHCII) molecules are present in body fluids of healthy individuals and are considered to be involved in the maintenance of self tolerance, while they are also related to various diseases. Their concentration increases during in vivo antigen-specific tolerogenic stimulation and it was recently shown that exosome-mediated tolerance is MHC-II dependent. At the cellular level, sMHC...

Clinical implications of interferon gamma genetic and epigenetic variants
submitted by bdobolas 14 minutes ago - Topic: Health
Interferon gamma (IFNγ) is an integral and critical molecule of the immune system, with multiple functions, mostly related to Th1 response to infection. It is critical to defence against mycobacterial infection and of increasing interest in defence against fungi. In this article, we review the genetic and epigenetic variants affecting IFNγ expression and investigate it's role in disease, with...

The number of the maximal triangle-free graphs
submitted by pitishorp11 18 minutes ago - Topic: Health
Paul Erdős suggested the following problem: Determine or estimate the number of maximal triangle-free graphs on $n$ vertices. Here we show that the number of maximal triangle-free graphs is at most $2^{n^2/8+o(n^2)}$, which matches the previously known lower bound. Our proof uses among others the Ruzsa–Szemerédi triangle-removal lemma, and recent results on characterizing of...

Compromised endothelium-dependent hyperpolarization-mediated dilations can be rescued by NS309 in obese Zucker rats
submitted by komolkamor 18 minutes ago - Topic: Health
Nitric oxide (NO) and a non-NO/prostacyclin endothelium-dependent hyperpolarization (EDH) mechanism are major contributors of vascular tone and cerebral blood flow. However the effect of metabolic syndrome on EDH-mediated responses in cerebral vessels is unknown and may offer another avenue for therapeutic targeting. The purpose of this study was to investigate EDH-dependent responses in cerebr...

Piezo channels: from structure to function
submitted by ojerili 20 minutes ago - Topic: Biology
Mechanotransduction is the conversion of mechanical stimuli into biological signals. It is involved in the modulation of diverse cellular functions such as migration, proliferation, differentiation, and apoptosis as well as in the detection of sensory stimuli such as air vibration and mechanical contact. Therefore, mechanotransduction is crucial for organ development and homeostasis and plays a...

Mechanosensory molecules and circuits in C. elegans
submitted by ojerili 20 minutes ago - Topic: Biology
Mechanosensory neurons, whose activity is controlled by mechanical force, underlie the senses of touch, hearing, and proprioception, yet despite their importance, the molecular basis of mechanotransduction is poorly understood. Genetic studies in Caenorhabditis elegans have provided a useful approach for identifying potential components of mechanotransduction complexes that might be conserved i...

Mechanotransduction in epidermal Merkel cells
submitted by ojerili 20 minutes ago - Topic: Biology
The cellular and molecular basis of vertebrate touch reception remains least understood among the traditional five senses. Somatosensory afferents that innervate the skin encode distinct tactile qualities, such as flutter, slip, and pressure. Gentle touch is thought to be transduced by somatosensory afferents whose tactile end organs selectively filter mechanical stimuli. These tactile end orga...

Somatic embryogenesis and in vitro plantlet regeneration in Salicornia brachiata Roxb
submitted by lenogholeb 24 minutes ago - Topic: Biology
Salicornia brachiata Roxb. (Amaranthaceae) a leaf-less annual succulent halophyte, grows under extremely saline conditions and is an important resource for salt stress responsive genes. Here we report somatic embryogenesis and in vitro plantlet regeneration in S. brachiata for the first time. In vitro-grown seedlings were used as explants and 86.0 ± 1.7 % explants produced embryogenic callu...

A new and efficient micropropagation method and its breeding applications in Asparagus genera
submitted by lenogholeb 24 minutes ago - Topic: Biology
Cultivated asparagus (Asparagus officinalis L.) is an economically important plant worldwide. “Morado de Huetor” is a Spanish autochthonous landrace characterized by their longevity, organoleptic characteristics, differential biocompound content and high heterozygosity, resulting in heterogeneous plantations with limited productivity. Consequently, this landrace suffers high risk of extinct...

Multichannel Imaging to Quantify Four Classes of Pharmacokinetic Distribution in Tumors
submitted by wosin 33 minutes ago - Topic: Health
Low and heterogeneous delivery of drugs and imaging agents to tumors results in decreased efficacy and poor imaging results. Systemic delivery involves a complex interplay of drug properties and physiological factors, and heterogeneity in the tumor microenvironment makes predicting and overcoming these limitations exceptionally difficult. Theoretical models have indicated that there are four di...

A Novel Experimental Design Method to Optimize Hydrophilic Matrix Formulations with Drug Release Profiles and Mechanical Properties
submitted by wosin 33 minutes ago - Topic: Health
To investigate the effects of hydrophilic polymers on the matrix system, an experimental design method was developed to integrate response surface methodology and the time series modeling. Moreover, the relationships among polymers on the matrix system were studied with the evaluation of physical properties including water uptake, mass loss, diffusion, and gelling index. A mixture simplex latti...

DevR (DosR) mimetic peptides impair transcriptional regulation and survival of Mycobacterium tuberculosis under hypoxia by inhibiting the autokinase activity of DevS sensor kinase
submitted by osebliy 38 minutes ago - Topic: Biology
Two-component systems have emerged as compelling targets for antibacterial drug design for a number of reasons including the distinct histidine phosphorylation property of their constituent sensor kinases. The DevR-DevS/DosT two component system of Mycobacterium tuberculosis (M. tb) is essential for survival under hypoxia, a stress associated with dormancy development in vivo. In the present st...

Endophytic bacterial community of grapevine leaves influenced by sampling date and phytoplasma infection process
submitted by osebliy 38 minutes ago - Topic: Biology
Endophytic bacteria benefit host plant directly or indirectly, e.g. by biocontrol of the pathogens. Up to now, their interactions with the host and with other microorganisms are poorly understood. Consequently, a crucial step for improving the knowledge of those relationships is to determine if pathogens or plant growing season influence endophytic bacterial diversity and dynamic. :Four healthy...