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Characterization of a mutant glucose isomerase from Thermoanaerobacterium saccharolyticum
submitted by vonisomorebil 28 minutes ago - Topic: Biology
A series of site-directed mutant glucose isomerase at tryptophan 139 from Thermoanaerobacterium saccharolyticum strain B6A were purified to gel electrophoretic homogeneity, and the biochemical properties were determined. W139F mutation is the most efficient mutant derivative with a tenfold increase in its catalytic efficiency toward glucose compared with the native GI. With a maximal activity a...



Experiences in anti-tuberculosis treatment in patients with multiple previous treatments and its impact on drug resistant tuberculosis epidemics
submitted by rmocep 29 minutes ago - Topic: Health
Tuberculosis (TB) patients with a history of multiple anti-TB treatments are the ‘neglected’ group to the free anti-TB treatment policy in China. To understand the experiences of TB patients with multiple previous treatments with regard to bacteriological diagnosis and treatment regimens, especially for second-line anti-TB drugs, and how this might influence the risks of multidrug and exten...

Scenario planning for community development in Vietnam: a new tool for integrated health approaches?
submitted by rmocep 29 minutes ago - Topic: Health
Like many countries in Southeast Asia, Vietnam’s rapid population and economic growth has met challenges in infrastructure development, especially sanitation in rural areas. As an entry point, we developed scenario planning as an action–research tool in a peri-urban community to identify first steps towards improving their complex sanitation problem and to, systemically, address emerging/re...

Interpretive focus groups: a participatory method for interpreting and extending secondary analysis of qualitative data
submitted by rmocep 29 minutes ago - Topic: Health
Participatory approaches to qualitative research practice constantly change in response to evolving research environments. Researchers are increasingly encouraged to undertake secondary analysis of qualitative data, despite epistemological and ethical challenges. Interpretive focus groups can be described as a more participative method for groups to analyse qualitative data. To facilitate inter...

Long-term Efficacy of Repeat Incisions of Bladder Neck/External Sphincter in Patients With Spinal Cord Injury
submitted by f1400265 29 minutes ago - Topic: Health
To evaluate the efficacy of repeat bladder neck incision (BNI), with or without external sphincterotomy (ES). BNI/ES has been commonly used for management of neurogenic bladder in spinal cord injury (SCI) patients. This was a retrospective review of institutional review board–approved SCI database. A total of 97 patients underwent BNI/ES over a period of 40 years. During the period reviewed,...



Fish Oil Supplementation and Urinary Oxalate Excretion in Normal Subjects on a Low-oxalate Diet
submitted by f1400265 29 minutes ago - Topic: Health
To determine if fish oil supplementation reduces endogenous oxalate synthesis in healthy subjects. Fifteen healthy non–stone-forming adults participated in this study. Subjects first abstained from using vitamins, medications, or foods enriched in omega-3 fatty acids for 30 days. Next, they collected two 24-hour urine specimens while consuming a self-selected diet. Subjects consumed an extre...

Sulforaphane Restores Oxidative Stress Induced by Di-n-butylphthalate in Testicular Leydig Cells With Low Basal Reactive Oxygen Species Levels
submitted by f1400265 29 minutes ago - Topic: Health
To investigate the role and therapeutic potential of Nuclear factor erythroid-related factor 2 (Nrf2) in oxidative stress induced by di-N-butylphthalate (DBP) in testicular Leydig cells. Levels of reactive oxygen species (ROS) and Nrf2 in testicles from offspring of mice fed with DBP were studied. Basal ROS and Nrf2 level in mouse TM3 testicular Leydig cells were studied. Cells were treated wit...


Prediction of Multifocal Lesions in Patients With Upper Tract Urothelial Carcinoma
submitted by f1400265 29 minutes ago - Topic: Health
To identify predictive factors for multifocal lesions in patients with upper tract urothelial carcinoma (UTUC). Between June 1996 and September 2013, a cohort of 147 patients underwent radical nephroureterectomy at our institution. Univariate and multivariate logistic regression analyses were performed to identify clinical covariates significantly associated with the multifocal UTUC lesions and...

Hypertriglyceridemia Is Associated With Increased Risk for Stone Recurrence in Patients With Urolithiasis
submitted by f1400265 29 minutes ago - Topic: Health
To assess the influence of dyslipidemia on urinary lithogenic metabolites and stone recurrence in stone formers. We retrospectively selected 321 patients with urolithiasis who had been followed up for >24 months between 2004 and 2009. Fasting blood samples were taken, and serum lipid profiles were measured. All subjects also underwent 24-hour urinary metabolic evaluation and stone analy...


Association Between Ureteral Jet Dynamics and Nonobstructive Kidney Stones: A Prospective-controlled Study
submitted by f1400265 29 minutes ago - Topic: Health
To evaluate the possible alterations in ureteral jet dynamics which inform physicians about ureteral physiology and peristaltism in nonobstructive kidney stone formers with this prospective-controlled study. All patients with flank pain eligible for the study underwent Doppler ultrasonoghraphy examination for evaluation of ureteral jet dynamics and non–contrast-enhanced computed tomography fo...

Long-term Outcomes in Severe Lower Urinary Tract Symptoms in Men Undergoing Robotic-assisted Radical Prostatectomy
submitted by f1400265 29 minutes ago - Topic: Health
To address a major concern driving treatment intervention, we studied incontinence and urinary quality of life (QOL) before and after robotic-assisted radical prostatectomy (RARP). In men with severe lower urinary tract symptoms (LUTS), this is the first observational study analyzing short- and long-term urinary outcomes of RARP. RARP was performed on 665 patients by 1 surgeon from 2002 to 2007...


Risk Factors for Erosion of Artificial Urinary Sphincters: A Multicenter Prospective Study
submitted by f1400265 29 minutes ago - Topic: Health
To evaluate the short- to medium-term outcomes after artificial urinary sphincter (AUS) placement from a large, multi-institutional, prospective, follow-up study. We hypothesize that along with radiation, patients with any history of a direct surgery to the urethra will have higher rates of eventual AUS explantation for erosion and/or infection. A prospective outcome analysis was performed on 3...

The Management of Bulbar Urethral Stricture Disease Before Referral for Definitive Repair: Have Practice Patterns Changed?
submitted by f1400265 29 minutes ago - Topic: Health
To describe the management of patients with bulbar urethral stricture disease before referral for definitive urethroplasty and determine if practice patterns have changed with respect to endoscopic interventions. We performed an institutional review board–approved retrospective review and recorded patient demographics, stricture-related information, and all procedures performed for bulbar ure...

Prospective Health-related Quality of Life Analysis for Patients Undergoing Radical Cystectomy and Urinary Diversion
submitted by f1400265 29 minutes ago - Topic: Health
To better define health-related quality of life (HRQOL) for patients undergoing radical cystectomy (RC) and urinary diversion. Patients undergoing RC and urinary diversion for urothelial carcinoma by 1 of 2 surgeons (G. D. S. or N. D. S.) had a HRQOL assessment at baseline and at follow-up using the validated, bladder cancer–specific Functional Assessment of Cancer Therapy–Vanderbilt Cystec...

Variation in Urinary Stone Composition Between Adult Uyghur and Han Patients With Urolithiasis in Xinjiang, China
submitted by f1400265 29 minutes ago - Topic: Health
To analyze variations in urinary stone composition between Uyghur and Han patients with urolithiasis in Xinjiang, China, and to explore the possible factors associated with urinary stone composition in Uyghur and Han patients. We analyzed the components of urinary stones in 317 adults (152 Uyghur and 165 Han) with urolithiasis admitted to our hospital from March 2009 to June 201Urinary stones w...