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Quantitative proteomics at different depths in human articular cartilage reveals unique patterns of protein distribution
submitted by vencieadeco 23 minutes ago - Topic: Biology
The articular cartilage of synovial joints ensures friction-free mobility and attenuates mechanical impact on the joint during movement. These functions are mediated by the complex network of extracellular molecules characteristic for articular cartilage. Zonal differences in the extracellular matrix (ECM)1 are well recognized. However, the knowledge about the precise molecular composition in t...



The Manx shearwater (Puffinus puffinus) as a candidate sentinel of Atlantic Ocean health
submitted by swenno 23 minutes ago - Topic: Environment
Seabirds have been historically used to monitor environmental contamination. The aim of the present study was to test the suitability of a species belonging to the Procellariiformes group, the Manx shearwater, Puffinus puffinus, as a sentinel of environmental health, by determining contaminant levels (trace metals and organochlorine compounds) from carcass tissues and by isolating Vibrio spp. a...

Gastric tube ulcer after esophagectomy
submitted by welsani 25 minutes ago - Topic: Health
An ulcer occasionally develops in the gastric tube as an esophageal substitute after esophagectomy. The aim of the present study was to investigate the risk factors for a gastric tube ulcer. We reviewed the medical records of all 826 patients who underwent esophageal reconstruction using a gastric tube following esophagectomy, in Kurume University Hospital between 1985 and 2010. Potential risk ...

The pathogenesis of persistent non-erosive reflux disease treated with proton-pump inhibitors as measured with the Symptom Index
submitted by welsani 25 minutes ago - Topic: Health
Non-erosive reflux disease (NERD) includes a heterogeneous patient group with varying clinical and pathophysiological characteristics. This study aims to elucidate the pathogenesis of persistent NERD despite of continuous proton-pump inhibitors (PPI) treatment using 24-h combined multichannel intraluminal impedance-pH monitoring (MII-pH). We enrolled fifty-four consecutive Japanese patients wit...

Esophageal cancer associated with bilateral hilar lymphadenopathy caused by sarcoid-like reactions: a report of two cases
submitted by welsani 25 minutes ago - Topic: Health
Hilar lymph node metastasis of esophageal cancer is considered to be a distant metastasis and is not indicated for surgical resection. However, its diagnosis is difficult when accompanied by inflammatory diseases such as sarcoidosis. We report two patients with esophageal cancer accompanied by bilateral hilar lymphadenopathy or accumulation on [18F]-fluorodeoxyglucose positron emission tomograp...



Between- and within-species trait variability and the assembly of sapling communities in forest patches
submitted by 9654 26 minutes ago - Topic: Agriculture
What is the magnitude of between-species trait variability (BSV) and within-species trait variability (WSV) of specific leaf area (SLA) in a sapling meta-community? To what extent do species turnover and WSV influence community-level mean trait responses to an environmental gradient and trait spread patterns across this gradient? What is the role of WSV for mean plant responses to environmental...

A comparison of long-term outcomes after meticillin-resistant and meticillin-sensitive Staphylococcus aureus bacteraemia: an observational cohort study
submitted by iddeiback2 28 minutes ago - Topic: Health
Findings from previous studies have suggested that outcomes after meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia are worse than after meticillin-sensitive S aureus (MSSA) bacteraemia. We assessed whether patients who had MRSA bacteraemia had a higher risk of death and recurrent infections than those who had MSSA bacteraemia. For this observational cohort study, we assessed data f...


Assessment of the novel T-cell activation marker–tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study
submitted by iddeiback2 28 minutes ago - Topic: Health
The diagnosis of paediatric tuberculosis is complicated by non-specific symptoms, difficult specimen collection, and the paucibacillary nature of the disease. We assessed the accuracy of a novel immunodiagnostic T-cell activation marker–tuberculosis (TAM-TB) assay in a proof-of-concept study to identify children with active tuberculosis. Children with symptoms that suggested tuberculosis were...

Why Wait? The Effect of Wait-Times on Subsequent Help-Seeking Among Families Looking for Children’s Mental Health Services
submitted by jomelqoder 30 minutes ago - Topic: Health
Placement on a wait-list may increase families’ help-seeking efforts, leading them to contact more than one children’s mental health (MH) agency/professional. Two issues were examined in the current study: 1) Does time on a wait-list for families impact the time to contact a new agency for children’s MH services? 2) What are the effects of predisposing (e.g., child age), need (e.g., child...


Regulation of (pro)renin receptor expression in mIMCD via the GSK-3beta-NFAT5-SIRT-1 signaling pathway
submitted by choll3 37 minutes ago - Topic: Biology
The localization and regulation of (pro)renin receptor (PRR) expression in kidney collecting duct cells are not well established. We hypothesized that low salt (LS) contributes to the regulation of PRR expression in these cells via the GSK-3β-NFAT5-sirtuin1 (SIRT-1) signaling pathway. Mouse inner medullary collecting duct (mIMCD) cells were treated with NaCl at 130 (normal salt; NS), 63 (L...

Insights into acidosis-induced regulation of SLC26A4 (pendrin) and SLC4A9 (AE4) transporters using three-dimensional morphometric analysis of beta-intercalated cells
submitted by choll3 37 minutes ago - Topic: Biology
The purpose of this study was to examine the three-dimensional (3-D) expression and distribution of anion transporters pendrin (SLC26A4) and anion exchanger (AE)4 (SLC4A9) in β-intercalated cells (β-ICs) of the rabbit cortical collecting duct (CCD) to better characterize the adaptation to acid-base disturbances. Confocal analysis and 3-D reconstruction of β-ICs, using identifiers...


Necrotizing fasciitis in liver cirrhosis
submitted by doasakm 37 minutes ago - Topic: Health
Necrotizing fasciitis (NF) is associated with a high mortality rate. Hepatitis is endemic in Taiwan, and liver cirrhosis is associated with the development of NF. The characteristics of these patients, however, have not been well documented or the predictors of mortality clearly identified. The purpose of this study is to identify predictors of mortality in patients with liver cirrhosis and nec...

Burr-hole drainage for chronic subdural hemorrhage complicated by an acute subdural hematoma located between the dura and the outer membrane space
submitted by doasakm 37 minutes ago - Topic: Health
Chronic subdural hematoma (SDH) is a common clinical entity in neurosurgery. Craniostomy, including twist-drill holes or burr holes with or without drainage, is the treatment of choice for SDH. Despite convincing results from this surgical procedure, unexpected complications may still develop such as acute epidural hematoma, acute SDH, intracerebral hemorrhage (ICH), tension pneumocephalus, and...

Relative abundance of short chain and polyunsaturated fatty acids in propionic acid-induced autistic features in rat pups as potential markers in autism
submitted by onondbeatich3121 37 minutes ago - Topic: Biology
Fatty acids are essential dietary nutrients, and one of their important roles is providing polyunsaturated fatty acids (PUFAs) for the growth and function of nervous tissue. Short chain fatty acids (SCFAs) are a group of compounds derived from the host microbiome that were recently linked to effects on the gut, the brain, and behavior. They are therefore linked to neurodevelopmental disorders s...

Waist circumference measures: cutoff analyses to detect obesity and cardiometabolic risk factors in a Southeast Brazilian middle-aged men population - a cross-sectional study
submitted by onondbeatich3121 37 minutes ago - Topic: Biology
Low-cost practical and reliable tools to evaluated obesity-related cardiometabolic diseases are of clinical practice and public heath relevance worldwide. The aims of this cross-sectional study were to determine the anatomical point of waist circumference that best identify overweight, obesity and central obesity in Southeast Brazilian middle-aged men and to test the relationships of its cutoff...