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Selective increase of in vivo firing frequencies in DA SN neurons after proteasome inhibition in the ventral midbrain
submitted by oenat 10 minutes ago - Topic: Health
The impairment of protein degradation via the ubiquitin-proteasome system (UPS) is present in sporadic Parkinson's disease (PD), and might play a key role in selective degeneration of vulnerable dopamine (DA) neurons in the substantia nigra pars compacta (SN). Further evidence for a causal role of dysfunctional UPS in familial PD comes from mutations in parkin, which results in a loss of functi...



Prenatal alcohol exposure and adolescent stress – unmasking persistent attentional deficits in rats
submitted by oenat 10 minutes ago - Topic: Health
Prenatal alcohol exposure (PAE) can produce a myriad of deficits. Unfortunately, affected individuals may also be exposed to the stress of an adverse home environment, contributing to deficits of attentional processes that are the hallmark of optimal executive function. Male offspring of ad-libitum-fed Control (Con), Pairfed (PF), and PAE dams were randomly assigned to either a 5-day period of ...

Downregulation of Centaurin gamma1A increases synaptic transmission at Drosophila larval neuromuscular junctions
submitted by oenat 10 minutes ago - Topic: Health
Adequate regulation of synaptic transmission is critical for appropriate neural circuit functioning. Although a number of molecules involved in synaptic neurotransmission have been identified, the molecular mechanisms regulating neurotransmission are not fully understood. Here, we focused on Centaurin gamma1A (CenG1A) and examined its role in synaptic transmission regulation using Drosophila la...

Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation
submitted by oenat 10 minutes ago - Topic: Health
Global cerebral ischemia following cardiac arrest and cardiopulmonary resuscitation (CA/CPR) causes injury to hippocampal CA1 pyramidal neurons and impairs cognition. Small conductance Ca2+-activated potassium channels type 2 (SK2), expressed in CA1 pyramidal neurons, have been implicated as potential protective targets. Here we showed that, in mice, hippocampal long-term potentiation (LTP) was...

Maximal freedom at minimum cost: linear large-scale structure in general modifications of gravity
submitted by zaleono 11 minutes ago - Topic: Geography
We present a turnkey solution, ready for implementation in numerical codes, for the study of linear structure formation in general scalar-tensor models involving a single universally coupled scalar field. We show that the totality of cosmological information on the gravitational sector can be compressed — without any redundancy — into five independent and arbitrary functions of time only an...



Leptogenesis with a dynamical seesaw scale
submitted by zaleono 11 minutes ago - Topic: Geography
In the simplest type-I seesaw leptogenesis scenario right-handed neutrino annihilation processes are absent. However, in the presence of new interactions these processes are possible and can affect the resulting B - L asymmetry in an important way. A prominent example is provided by models with spontaneous lepton number violation, where the existence of new dynamical degrees of freedom can play...

Hybrid inflation in the complex plane
submitted by zaleono 11 minutes ago - Topic: Geography
Supersymmetric hybrid inflation is an exquisite framework to connect inflationary cosmology to particle physics at the scale of grand unification. Ending in a phase transition associated with spontaneous symmetry breaking, it can naturally explain the generation of entropy, matter and dark matter. Coupling F-term hybrid inflation to soft supersymmetry breaking distorts the rotational invariance...


The Vainshtein mechanism in the cosmic web
submitted by zaleono 11 minutes ago - Topic: Geography
We investigate the dependence of the Vainshtein screening mechanism on the cosmic web morphology of both dark matter particles and halos as determined by ORIGAMI. Unlike chameleon and symmetron screening, which come into effect in regions of high density, Vainshtein screening instead depends on the dimensionality of the system, and screened bodies can still feel external fields. ORIGAMI is well...

Spectral line broadening in magnetized black holes
submitted by zaleono 11 minutes ago - Topic: Geography
We consider weakly magnetized non-rotating black holes. In the presence of a regular magnetic field the motion of charged particles in the vicinity of a black hole is modified. As a result, the position of the innermost stable circular orbit (ISCO) becomes closer to the horizon. When the Lorentz force is repulsive (directed from the black hole) the ISCO radius can reach the gravitational radius...


Effects of different restoration measures and sand dune topography on short- and long-term vegetation restoration in northeast China
submitted by girordamx 16 minutes ago - Topic: Geography
Our study investigated the effects of different restoration measures and sand dune topography on vegetation restoration in the Horqin Sandy Land, China. We conducted a vegetation survey at different topographic positions on sand dunes at four different types of restoration sites (i.e., grazing-exclusion, shrub-planting, pine-planting, and poplar-planting sites) with restoration periods of ≤35...

Cognitive impairment in obstructive sleep apnea
submitted by nelemo2077 33 minutes ago - Topic: Health
Obstructive sleep apnea (OSA) is characterised by repetitive cessation or reduction of airflow due to upper airway obstructions. These respiratory events lead to chronic sleep fragmentation and intermittent hypoxemia. Several studies have shown that OSA is associated with daytime sleepiness and cognitive dysfunctions, characterized by impairments of attention, episodic memory, working memory, a...


Clear Cell Carcinomas of the Ovary. Evaluation of Prognostic Parameters Based On a Clinicopathologic Analysis of 100 Cases
submitted by mecralrimideis 43 minutes ago - Topic: Health
The aim of this study was to evaluate the clinicopathologic features of ovarian clear cell carcinomas to identify which, if any, are prognostically significant and determine whether there is value in grading these tumors. One-hundred tumors with clinical follow-up were reviewed. Features evaluated included age, preoperative/intraoperative rupture, size, architectural pattern(s), presence of oxy...

Multifocal synchronous mucinous adenocarcinomas arising in congenital pulmonary airway malformation: a case report with molecular study
submitted by mecralrimideis 43 minutes ago - Topic: Health
Congenital pulmonary airway malformation (CPAM) is a rare developmental anomaly of the lung. Here, we report a case of mucinous adenocarcinoma arising in CPAM. A 23-month-old boy underwent a thoracoscopic lobectomy of the left upper lobe of the lung based on a presumptive diagnosis of asymptomatic CPAM, found in antenatal sonogram. & ResultsHistologically, the lesion was consistent with CPAM, S...

Novel use for an EGFR mutation-specific antibody in discriminating lung adenocarcinoma from reactive pneumocyte hyperplasia
submitted by mecralrimideis 43 minutes ago - Topic: Health
Pulmonary ground-glass nodules (GGNs) is frequently observed. Histopathologically, their presentation can indicate a wide range of disorders from an inflammatory process to malignancy. An accurate diagnosis based on GGNs can sometimes be challenging on small-sized biopsies. Mutations in the EGFR gene are detected in pulmonary adenocarcinomas (ADCs). Immunohistochemical analysis using antibodies...

Myoepithelioma of Bone with a Novel FUS-POU5F1 Fusion Gene
submitted by mecralrimideis 43 minutes ago - Topic: Health
Myoepithelial tumours of soft tissue are rare lesions with a broad morphological and clinical spectrum. Previous studies have found EWSR1 rearrangements in approximately half of all cases and PBX1, ZNF44 and POU5F1 have been identified as recurrent fusion partners. In bone, only a small number of myoepithelial tumours have been described. We investigated an intraosseous myoepithelioma of the sa...