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AQP4 plasma membrane trafficking or channel gating is not significantly modulated by phosphorylation at C-terminal serine residues
submitted by dorodero 8 minutes ago - Topic: Biology
Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. AQP4 serves as a water entry site during brain edema formation and regulation of AQP4 may therefore be of therapeutic interest. Phosphorylation of aquaporins can regulate plasma membrane localization and, possibly, the unit water perm...



Sphingosine kinase 1 (Sphk1) negatively regulates platelet activation and thrombus formation
submitted by dorodero 8 minutes ago - Topic: Biology
Sphingosine 1-phosphate (S1P) is a powerful regulator of platelet formation. Enzymes generating S1P include sphingosine kinase The present study thus explored the role of sphingosine kinase 1 in platelet formation and function. Activation-dependent platelet integrin αIIbβ3 activation and secretion of platelets lacking functional sphingosine kinase 1 (sphk1-/-) were determined utilizi...

Protein Kinase C mediated phosphorylation of RKIP regulates inhibition of Na-alanine co-transport by Leukotriene D4 in intestinal epithelial cells
submitted by dorodero 8 minutes ago - Topic: Biology
Leukotriene D4 (LTD4) is an important immune inflammatory mediator known to be elevated in the mucosa of chronically inflamed intestine and alter nutrient absorption. LTD4 inhibits Na-alanine co-transport in intestinal epithelial cells by decreasing the affinity of the co-transporter, ASCTLTD4 is known to increase intracellular Ca++ and cAMP concentrations. However, the intracellular signaling ...

The perceived burden of epilepsy: Impact on the quality of life of children and adolescents and their families
submitted by obroshen 9 minutes ago - Topic: Health
The assessment of the quality of life (QoL) is relevant for a comprehensive treatment of patients with epilepsy. In children and adolescents, an impact of epilepsy on the QoL of the entire family is expected. We asked 293 parents of children and adolescents with epilepsy to evaluate the impact of the disease on several aspects of the QoL of the whole family using a specifically organized questi...

Characterizing plasma albumin concentration changes in TB/HIV patients on anti retroviral and anti ¿tuberculosis therapy
submitted by spedirmon83 9 minutes ago - Topic: Health
Plasma albumin, a biomarker for hepatic function, is reported to correspondingly decrease in concentration as disease severity increases in chronic infections including HIV and TB. Our objective was to develop a semi-mechanistic disease progression model to quantify plasma albumin concentration changes during TB and HIV therapy and identify the associated covariate factors. Plasma albumin conce...



Regulation of local steroidogenesis in the brain and in prostate cancer: Lessons learned from interdisciplinary collaboration
submitted by vencieadeco 9 minutes ago - Topic: Health
Sex steroids play critical roles in the regulation of the brain and many other organs. Traditionally, researchers have focused on sex steroid signaling that involves travel from the gonads via the circulation to intracellular receptors in target tissues. This classic concept has been challenged, however, by the growing number of cases in which steroids are synthesized locally and act locally wi...

Delineating the Regulation of Energy Homeostasis Using Hypothalamic Cell Models
submitted by vencieadeco 9 minutes ago - Topic: Health
Attesting to its intimate peripheral connections, hypothalamic neurons integrate nutritional and hormonal cues to effectively manage energy homeostasis according to the overall status of the system. Extensive progress in the identification of essential transcriptional and post-translational mechanisms regulating the controlled expression and actions of hypothalamic neuropeptides has been identi...


Sphingorhabduspacificus sp. nov., isolated from sandy sediments of the Sea of Japan seashore
submitted by moreonni 10 minutes ago - Topic: Biology
An aerobic, Gram-negative, yellow-pigmented, non-motile rod-shaped bacterium designated KMM 9574T was isolated from a sand sediment sample collected from the Sea of Japan seashore. Comparative 16S rRNA gene sequence analysis showed that strain KMM 9574T belonged to the genus Sphingorhabdus sharing a highest sequence similarity to Sphingorhabdusmarina JCM 14161T 96.8 %. Strain KMM 9574T was cha...

A seroprevalence survey on varicella among adults in the vaccination era in Apulia (Italy)
submitted by hagh 18 minutes ago - Topic: Health
In 2006, the Apulia Region (Italy) introduced universal routine vaccination (URV) against varicella disease. The coverage for one dose of varicella vaccine at 24 month of age reached 91.1% in 2010 birth-cohort. Vaccination coverage for the second dose at 5–6 years was 64.8% for the cohort 2005, and 28.8% for adolescents born in 1997. The aim of the present study is to evaluate the pattern of ...


Parental acceptance of inactivated polio vaccine in Southeast Nigeria: A qualitative cross-sectional interventional study
submitted by hagh 18 minutes ago - Topic: Health
The introduction of inactivated polio vaccines (IPV) is imminent. In view of the Polio Eradication and Endgame Strategic Plan 2013–2018, parental acceptance of IPV will be important for achieving universal coverage. In view of the imminent introduction of IPV, it is only reasonable to assess the awareness and acceptance of IPV, so that necessary socio-anthropological measures would be put in ...

CD8+ T cell immunity against human respiratory syncytial virus
submitted by hagh 18 minutes ago - Topic: Health
Human respiratory syncytial virus (HRSV) was first discovered in the 1950s, but despite decades of research, a licensed vaccine against it is not available. Epidemiological studies indicate that antibodies directed against the fusion protein (F) partially correlate with protection. In addition, an F-specific monoclonal antibody is licensed as a prophylactic treatment in children who are at high...


Influenza vaccine effectiveness estimates for Western Australia during a period of vaccine and virus strain stability, 2010 to 2012
submitted by hagh 18 minutes ago - Topic: Health
During 2010–2012 the strain composition of the influenza vaccine in the Southern Hemisphere did not change, but the circulating virus type/subtype did. We pooled data for these years from the Western Australian sentinel medical practice surveillance system for influenza to estimate vaccine effectiveness (VE) by influenza virus type and subtype. A case test-negative design was used with VE est...

Helicobacter pylori outer inflammatory protein DNA vaccine-loaded bacterial ghost enhances immune protective efficacy in C57BL/6 mice
submitted by hagh 18 minutes ago - Topic: Health
Helicobacter pylori (H. pylori) infection is associated with incidents of gastrointestinal diseases in half of the human population. However, management of its infection remains a challenge. Hence, it is necessary to develop an efficient vaccine to fight against this pathogen. In the present study, a novel vaccine based on the production of attenuated Salmonella typhimurium bacterial ghost (SL7...

Immunogenicity of bivalent HPV vaccine among partially vaccinated young adolescent girls in Uganda
submitted by hagh 18 minutes ago - Topic: Health
Investigations of vaccine efficacy and immunogenicity for adult females receiving fewer than three doses of human papillomavirus (HPV) vaccine have suggested protection against infection and precancerous lesions. We investigated the immunogenicity of bivalent HPV vaccines among adolescent girls from Uganda who received one, two, or three vaccine doses. Young girls vaccinated through a governmen...

Evaluation of safety and efficacy as an adjuvant for the chitosan-based vaccine delivery vehicle ViscoGel in a single-blind randomised Phase I/IIa clinical trial
submitted by hagh 18 minutes ago - Topic: Health
ViscoGel, a chitosan-based hydrogel, has earlier been shown to improve humoral and cell-mediated immune responses in mice. In this study, a Phase I/IIa clinical trial was conducted to primarily evaluate safety and secondarily to study the effects of ViscoGel in combination with a model vaccine, Act-HIB to Haemophilus influenzae type b, administered as a single intramuscular injection. Healthy v...