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The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics
submitted by jomobags466 10 minutes ago - Topic: Health
The Wnt proteins are a family of 19 secreted glycoproteins that occupy crucial roles in the regulation of processes such as cell survival, proliferation, migration and polarity, cell fate specification, body axis patterning and self-renewal in stem cells. The canonical pathway has been implicated in a variety of cancers. As such, it is only fair to conclude that therapies targeting the Wnt path...



Phenolic constituents from stem bark of Erythrina poeppigiana and their inhibitory activity on human glyoxalase I
submitted by rosho622 11 minutes ago - Topic: Health
A novel isoflavone, erythgianin A (1), along with nine known compounds 2–10, was isolated from the stem bark of Erythrinapoeppigiana (Leguminosae). The unusual isoflavone structure of 1, possessing a highly oxidized 3″,4″-dihydroxy-2″-hydroxymethyl-2″-methyl-2″,3″-dihydropyrano substituent, was determined on the basis of spectroscopic analyses. All of the isolated compounds were e...

Endothelial glycocalyx on brain endothelial cells is lost in experimental cerebral malaria
submitted by jasicongos 12 minutes ago - Topic: Health
We hypothesized that the glycocalyx, which is important for endothelial integrity, is lost in severe malaria. C57BL/6 mice were infected with Plasmodium berghei ANKA, resulting in cerebral malaria, or P. chabaudi AS, resulting in uncomplicated malaria. We visualized the glycocalyx with transmission electron microscopy and measured circulating glycosaminoglycans by dot blot and ELISA. Th...

Repeated mild traumatic brain injury causes chronic neuroinflammation, changes in hippocampal synaptic plasticity, and associated cognitive deficits
submitted by jasicongos 14 minutes ago - Topic: Health
Repeated mild traumatic brain injury (mTBI) can cause sustained cognitive and psychiatric changes, as well as neurodegeneration, but the underlying mechanisms remain unclear. We examined histologic, neurophysiological, and cognitive changes after single or repeated (three injuries) mTBI using the rat lateral fluid percussion (LFP) model. Repeated mTBI caused substantial neuronal cell loss and s...

Snapshot MR technique to measure OEF using rapid frequency mapping
submitted by jasicongos 14 minutes ago - Topic: Health
Magnetic resonance (MR)-based oxygen extraction fraction (OEF) measurement techniques that use blood oxygen level-dependent (BOLD)-based approaches require the measurement of the R2’ decay rate and deoxygenated blood volume to derive the local oxygen saturation in vivo. We describe here a novel approach to measure OEF using rapid local frequency mapping. By modeling the MR decay process...



Concurrent and prospective associations of habitual overgeneral memory and prospection with symptoms of depression, general anxiety, obsessive compulsiveness, and post-traumatic stress
submitted by mvonzannivild 20 minutes ago - Topic: Health
Reduced memory specificity is associated with depression, post-traumatic stress disorder (PTSD), and some other forms of psychopathology. Reduced memory specificity is also associated with reduced specificity of envisioned future events. Research in this area has mostly relied on cue-word methods that include explicit instructions to develop specific memories of future events. These methods are...

Placental transfer and concentrations of cadmium, mercury, lead, and selenium in mothers, newborns, and young children
submitted by pporminteir 23 minutes ago - Topic: Health
There is an emerging hypothesis that exposure to cadmium (Cd), mercury (Hg), lead (Pb), and selenium (Se) in utero and early childhood could have long-term health consequences. However, there are sparse data on early life exposures to these elements in US populations, particularly in urban minority samples. This study measured levels of Cd, Hg, Pb, and Se in 50 paired maternal, umbilical cord, ...


Multiple pathway asbestos exposure assessment for a Superfund community
submitted by pporminteir 23 minutes ago - Topic: Health
Libby, MT, USA, was the home to workers at a historical vermiculite mining facility and served as the processing and distribution center for this industrial product that was contaminated with amphibole asbestos. Several pathways of environmental asbestos exposure to the general population have been identified. The local clinic and health screening program collects data from participants on past...

Escalating burden of breast cancer in southern Thailand: Analysis of 1990–2010 incidence and prediction of future trends
submitted by sajotho 24 minutes ago - Topic: Health
Thailand is undergoing an epidemiologic transition, with decreasing incidence of infectious diseases and increasing rates of chronic conditions, including cancer. Breast cancer has the highest incidence rates among females both in the southern region Thailand and throughout Thailand. However, there is a lack of research on the epidemiology of this and other cancers. Here we use cancer incidence...


Distribution of anticoagulant rodenticide resistance in Rattus norvegicus in the Netherlands according to Vkorc1 mutations
submitted by bole 24 minutes ago - Topic: Agriculture
Rodenticide resistance to anticoagulants in Rattus norvegicus will lead to increased difficulties in combating these pest animals. Here, we present the results of a survey in the Netherlands where tissue samples and droppings were tested using a newly-developed TaqMan PCR-test for genotypic variation at codon 139 in the Vkorc1 gene associated with anticoagulant rodenticide resistance. Test resu...

Survey on whiteflies and their parasitoids in cassava mosaic pandemic areas of Tanzania using morphological and molecular techniques
submitted by bole 24 minutes ago - Topic: Agriculture
Bemisia tabaci (Gennadius) is the vector of cassava mosaic geminiviruses (CMGs) and cassava brown streak viruses (CBSVs) in Africa that cause devastating yield losses. As a prerequisite to developing biological control methods and enhancing knowledge of the fauna of whitefly parasitoids in sub-Saharan Africa, endemic parasitoids were surveyed in the cassava-growing regions of Tanzania and analy...


Adjunct ultrasonography in children with suspected acute appendicitis: identifying the optimal target group
submitted by mawo531 25 minutes ago - Topic: Health
Role of ultrasonography in diagnosis of acute appendicitis in children is being debated. This study was conducted ahead of a clinical trial and aimed to evaluate the adjunctive role of ultrasonography in this group. Retrospective chart review of consecutive children undergoing appendicectomy in an Australian tertiary children's hospital over 24 months. Two study groups were: clinical assessment...

Historical aspects of appendicitis in children
submitted by mawo531 25 minutes ago - Topic: Health
Evidence of appendicitis exists from ancient Egyptian mummies but the appendix was not discovered as an anatomical entity until the renaissance in Western European literature. Much confusion reigned over the cause of right iliac fossa inflammatory disease until the late 19th century, when the appendix was recognized as the cause of the great majority of cases. Coining the term ‘appendicitis...

To infiltrate or not? Acute effects of local anaesthetic in breast surgery
submitted by mawo531 25 minutes ago - Topic: Health
There is limited evidence to support use of local anaesthetic (LA) wound infiltration in breast surgery. This study seeks to examine whether wound infiltration of bupivacaine (0.25%) decreases post-operative pain and analgesic use, without increasing post-operative complications. A prospective single-blind study was undertaken of 90 patients undergoing breast lump excision, wide local excision ...

Sentinel lymph node biopsy before mastectomy and immediate breast reconstruction does not significantly delay surgery in early breast cancer
submitted by mawo531 25 minutes ago - Topic: Health
Sentinel lymph node biopsy (SLNB) before mastectomy and immediate breast reconstruction (IBR) may help to avoid the negative cosmetic effects of radiotherapy on reconstructed breasts in lymph node-positive patients. Concerns have been raised regarding possible delays whilst awaiting the SLNB result prior to definitive surgery, which needs to be performed within 31 days of cancer diagnosis. The ...