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Double-chambered left ventricle in a cat
submitted by 19 minutes ago - Topic: Biology
Double-chambered left ventricle is a rare congenital disorder in which the left ventricular cavity is subdivided into two cavities by an anomalous septum or muscle band. We describe a case of double-chambered left ventricle, most likely caused by the presence of excessive left ventricular bands, in an asymptomatic cat.

Anatomía ecográfica abdominal normal. Sistemática de exploración
submitted by 25 minutes ago - Topic: Health
Para realizar una exploración ecográfica abdominal lo más completa y precisa posible es fundamental conocer bien la anatomía y las medidas normales de los distintos órganos. De esta manera conoceremos la normalidad y con mayor facilidad identificaremos la patología y su localización. Es muy importante tener una adecuada sistemática de exploración con el fin de llevar siempre la misma d...

Identification of novel molecular regulators of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening
submitted by 26 minutes ago - Topic: Health
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the downstream executioner caspases, caspase-3 and caspase-7 (caspase-3/7). Triple-negative breast cancer (TNBC) cell lines with a mesenchymal phenotype are sensitive to TRAIL while other breast c...

Ribosomal DNA Organization Patterns within the Dinoflagellate Genus Alexandrium as Revealed by FISH: Life Cycle and Evolutionary Implications
submitted by 28 minutes ago - Topic: Biology
Dinoflagellates are a group of protists whose genome differs from that of other eukaryotes in terms of size (contains up to 250pg per haploid cell), base composition, chromosomal organization, and gene expression. But rDNA gene mapping of the active nucleolus in this unusual eukaryotic genome has not been carried out thus far. Here we used FISH in dinoflagellate species belonging to the genus A...

Anatomically motivated modeling of cortical laminae
submitted by 44 minutes ago - Topic: Health
Improvements in the spatial resolution of structural and functional MRI are beginning to enable analysis of intracortical structures such as heavily myelinated layers in 3D, a prerequisite for in-vivo parcellation of individual human brains. This parcellation can only be performed precisely if the profiles used in cortical analysis are anatomically meaningful. Profiles are often constructed as ...

A computational framework for ultra-high resolution cortical segmentation at 7Tesla
submitted by 44 minutes ago - Topic: Health
This paper presents a computational framework for whole brain segmentation of 7Tesla magnetic resonance images able to handle ultra-high resolution data. The approach combines multi-object topology-preserving deformable models with shape and intensity atlases to encode prior anatomical knowledge in a computationally efficient algorithm. Experimental validation on simulated and real brain images...

Using high-resolution quantitative mapping of R1 as an index of cortical myelination
submitted by 44 minutes ago - Topic: Health
A fundamental tenet of neuroscience is that cortical functional differentiation is related to the cross-areal differences in cyto-, receptor-, and myeloarchitectonics that are observed in ex-vivo preparations. an ongoing challenge is to create noninvasive magnetic resonance (MR) imaging techniques that offer sufficient resolution, tissue contrast, accuracy and precision to allow for characteriz...

In vivo architectonics: A cortico-centric perspective
submitted by 44 minutes ago - Topic: Health
Recent advances in noninvasive structural imaging have opened up new approaches to cortical parcellation, many of which are described in this special issue on In Vivo Brodmann Mapping. In this introductory article, we focus on the emergence of cortical myelin maps as a valuable way to assess cortical organization in humans and nonhuman primates. We demonstrate how myelin maps are useful in thre...

Quantifying cerebral blood flow in an adult pig ischemia model by a depth-resolved dynamic contrast-enhanced optical method
submitted by 44 minutes ago - Topic: Health
Dynamic contrast-enhanced (DCE) near-infrared (NIR) methods have been proposed for bedside monitoring of cerebral blood flow (CBF). These methods have primarily focused on qualitative approaches since scalp contamination hinders quantification. In this study, we demonstrate that accurate CBF measurements can be obtained by analyzing multi-distance time-resolved DCE data with a combined kinetic ...

Fast and accurate modelling of longitudinal and repeated measures neuroimaging data
submitted by 44 minutes ago - Topic: Health
Despite the growing importance of longitudinal data in neuroimaging, the standard analysis methods make restrictive or unrealistic assumptions (e.g., assumption of Compound Symmetry—the state of all equal variances and equal correlations—or spatially homogeneous longitudinal correlations). While some new methods have been proposed to more accurately account for such data, these methods are ...

Manifold population modeling as a neuro-imaging biomarker: Application to ADNI and ADNI-GO
submitted by 44 minutes ago - Topic: Health
We propose a framework for feature extraction from learned low-dimensional subspaces that represent inter-subject variability. The manifold subspace is built from data-driven regions of interest (ROI). The regions are learned via sparse regression using the mini-mental state examination (MMSE) score as an independent variable which correlates better with the actual disease stage than a discrete...

Device for simultaneous positron emission tomography, laser speckle imaging and RGB reflectometry: Validation and application to cortical spreading depression and brain ischemia in rats
submitted by 44 minutes ago - Topic: Health
Brain function critically relies on the supply with energy substrates (oxygen and glucose) via blood flow. Alterations in energy demand as during neuronal activation induce dynamic changes in substrate fluxes and blood flow. To study the complex system that regulates cerebral metabolism requires the combination of methods for the simultaneous assessment of multiple parameters. We developed a mu...

Actions of Circulating Angiotensin II and Aldosterone in the Brain Contributing to Hypertension
submitted by 46 minutes ago - Topic: Health
In the past 1–2 decades, it has become apparent that the brain renin-angiotensin-aldosterone system (RAAS) plays a crucial role in the regulation of blood pressure (BP) by the circulating RAAS. In the brain, angiotensinergic sympatho-excitatory pathways do not contribute to acute, second-to-second regulation but play a major role in the more chronic regulation of the setpoint for sympathe...

Differences Between the Fourth and Fifth Korotkoff Phases Among Children and Adolescents
submitted by 46 minutes ago - Topic: Health
The relative importance of the fourth (K4) and fifth (K5) Korotkoff phases as the indicator of diastolic blood pressure (DBP) levels among children remains uncertain. In a sample of 11,525 youth aged 5–17, we examined interexaminer differences in these 2 phases and the relation of theses 2 phases to adult blood pressure levels and hypertension. The longitudinal analyses were conducted amo...

Inpatient costs of fire-related injuries in Finland
submitted by 47 minutes ago - Topic: Health
The aim of this study was to approximate the direct health care costs of fire-related injuries in inpatient care in Finland. Using the PERFECT costing method, cost data from both Finnish burn centres were linked to the fire-related injury patient data from the Finnish National Hospital Discharge Register (FHDR, 2001–2009). Additionally, a sample of 168 patients from the Helsinki Burn Centre w...

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