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Infection caused by an unusual isolate of non-tuberculosis mycobacteria in Iran
submitted by stiphinhjocabsan 45 minutes ago - Topic: Biology
Sequence-based identification of non-tuberculosis mycobacteria (NTM) has become a method of choice in mycobacteriology laboratories and is accomplished by analysis of several targets, such as 16S rRNA, rpoB, hsp65, sodA, etc. A group of pigmented, sl owl-growing mycobacteria were isolated from clinical samples of four unrelated patients with which were undefined at species level by means of phe...



Cell wall-associated Mycobacterium tuberculosis rRv3083 protein stimulates macrophages through toll-like receptor-2 (TLR2)
submitted by stiphinhjocabsan 45 minutes ago - Topic: Biology
Characterization of proteins associated with the mycobacterial cell wall is critical to understanding bacterial survival and immune modulation in the host. A variety of mycobacterial products are able to recognize and activate mammalian toll-like receptors (TLRs) mediating the secretion of antibacterial effector molecules. Mycobacterium tuberculosis MymA Rv3083 protein is a cell wall-associated...

Molecular Evolution of the Odorant and Gustatory Receptor Genes in Lepidopteran Insects: Implications for Their Adaptation and Speciation
submitted by mnasawetz 48 minutes ago - Topic: Biology
Lepidoptera (comprised of butterflies and moths) is one of the largest groups of insects, including more than 160,000 described species. Chemoreception plays important roles in the adaptation of these species to a wide range of niches, e.g., plant hosts, egg-laying sites, and mates. This study investigated the molecular evolution of the lepidopteran odorant (Or) and gustatory receptor (Gr) gene...

Negative Purifying Selection Drives Prion and Doppel Protein Evolution
submitted by mnasawetz 49 minutes ago - Topic: Biology
The prion protein (PrP) when misfolded into the pathogenic conformer PrPSc is the major causative agent of several lethal transmissible spongiform encephalopathies in mammals. Studies of evolutionary pressure on the corresponding gene using different datasets have yielded conflicting results. In addition, putative PrP or PrP interacting partners with strong similarity to PrP such as the doppel ...

Expression of metabolism-related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma
submitted by corlahomilenck 54 minutes ago - Topic: Health
The purpose of this study is to investigate the difference in expression of metabolism-related proteins in invasive lobular carcinoma (ILC) compared to those of the invasive ductal carcinoma (IDC). Tissue microarray was manufactured for 114 cases of ILC and 692 cases of IDC. Immunohistochemical stains were performed as follows: glycolysis (Glut-1, hexokinase II, CAIX, MCT4), glutaminolysis (GLS...



Risk/benefit profile of panitumumab-based therapy in patients with metastatic colorectal cancer: evidence from five randomized controlled trials
submitted by corlahomilenck 54 minutes ago - Topic: Health
This study aims to evaluate the risk and benefit profiles of panitumumab-based therapy (PBT) in patients with metastatic colorectal cancer (mCRC). Relevant randomized controlled trials were identified by searching PubMed, Medline, EMBASE and Cochrane Library. Data on progression-free survival (PFS), overall survival (OS), all grade and severe (grade ≥3) adverse events were extracted and poole...

LPS promotes epithelial–mesenchymal transition and activation of TLR4/JNK signaling
submitted by corlahomilenck 54 minutes ago - Topic: Health
The endotoxin level in the portal and peripheral veins of hepatocellular carcinoma (HCC) patients is higher and lipopolysaccharide (LPS), has been reported to inhibit tumor growth. However, in this study, we found that LPS-induced Toll-like receptor 4 (TLR4) signaling was involved in tumor invasion and the molecular mechanism was investigated. The HCC cells were used to study the invasion abili...


Association of functional polymorphism at the miR-502-binding site in the 3′ untranslated region of the SETD8 gene with risk of childhood acute lymphoblastic leukemia, a preliminary report
submitted by corlahomilenck 54 minutes ago - Topic: Health
MicroRNAs (miRNAs), a class of non-coding RNAs, bind to the 3′ untranslated regions (UTRs) of mRNAs, where they interfere with translation of genes and are implicated in the pathogenesis of diverse diseases. In the present study, we evaluate the impact of rs16917496 polymorphism within the miR-502 miRNA seed region at the 3′UTR of SEDT8 on childhood acute lymphoblastic leukemia (ALL). This ...

Preoperative predicting score of lymph node metastasis for gastric cancer
submitted by corlahomilenck 54 minutes ago - Topic: Health
The aim of our study was to develop a new score system that might predict the probability of lymph node of gastric carcinoma. We studied the clinicopathological variables of 932 patients with gastric carcinoma admitted to the Department of Surgical Oncology at the First Hospital of China Medical University. Logistic analysis was performed to identify predictors. The hazard risk (HR) of variable...


Meta-analyses of methylation markers for prostate cancer
submitted by corlahomilenck 54 minutes ago - Topic: Health
Prostate cancer (PCa) is the most frequently diagnosed non-cutaneous cancer that has become the sixth leading cause of mortality in both the developed and developing countries. Accumulating evidence showed a number of genes with aberrant DNA methylation in the pathogenesis of PCa. Here, we conducted a systematic meta-analysis to evaluate the contribution of aberrantly methylated genes to the ri...

Systematic review of high-dose and standard-dose chemotherapies in the treatment of primary well-differentiated osteosarcoma
submitted by corlahomilenck 54 minutes ago - Topic: Health
The objective of this study is to evaluate whether high-dose chemotherapy is more efficacious than standard-dose chemotherapy in the treatment of primary well-differentiated osteosarcoma. The Cochrane systematic evaluation method was adopted. A database search was conducted in MEDLINE, Embase, OVID, the Cochrane Central Register of Controlled Trials database and the Chinese Biomedical Literatur...


Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α
submitted by corlahomilenck 54 minutes ago - Topic: Health
Hypoxia is a widespread phenomenon present in many human solid tumors and is associated with a poor prognosis and therapy resistance. Here, we tested the feasibility of melittin, a major component of bee venom, on radiosensitization of hypoxic head and neck squamous cell carcinoma (HNSCC). CNE-2 and KB cells were treated with melittin and radiation response was determined. Cell viability, cytot...

Identification of circulating microRNAs as biomarkers in diagnosis of hematologic cancers: a meta-analysis
submitted by corlahomilenck 54 minutes ago - Topic: Health
Recent studies have provided new insights into the diagnostic value of circulating microRNAs (miRNAs) for hematologic cancers. However, inconsistent results have been reported on the diagnostic performance of various kinds of miRNAs. To systematically assess the potential diagnostic value of miRNAs in hematologic cancers, we conducted the present meta-analysis. Multiple databases (PubMed, Cochr...

Variation risks of SFRP2 hypermethylation between precancerous disease and colorectal cancer
submitted by corlahomilenck 54 minutes ago - Topic: Health
DNA hypermethylation of secreted frizzled-related protein 2 (SFRP2) gene associated with the Wnt signaling pathway has been studied previously. However, the risk size and changing rules between colorectal cancer (CRC) and SFRP2 hypermethylation from precancerous disease to CRC remain unclear. The aim of work was therefore to investigate the risk size and changing rule based on detections on lar...

Promoter methylation and polymorphism of E-cadherin gene may confer a risk to prostate cancer: a meta-analysis based on 22 studies
submitted by corlahomilenck 54 minutes ago - Topic: Health
Emerging evidence has suggested that −160C/A polymorphism and promoter methylation of E-cadherin gene may contribute to the risk of prostate cancer. However, the results are still conflicting. We aim to systematically evaluate the potential of promoter methylation and polymorphism in E-cadherin gene to confer a risk to prostate cancer through meta-analysis. PubMed, Embase, Web of Science, Coc...