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Water–energy–pollution nexus for growing cities
submitted by omoloa 12 minutes ago - Topic: Geography
Most recognised global challenges of modern times are related to energy production and consumption. The trends of energy demand for a growing world population and global urbanisation have raised serious concerns, and they are often termed as “global challenges” that include climate change, pollution and demands of clean water, food and energy. In thematic debate of the 2013 UN General Assem...



Relationship dimensions of the ‘Down syndrome advantage’
submitted by 992096 16 minutes ago - Topic: Health
Some researchers have proposed an ‘advantage’ for parents of children with Down syndrome over parents of children with other intellectual disabilities, especially in relation to experiencing less parenting stress. Others have maintained that these differences are an artefact of demographic and related differences. This study extends the investigation of possible differences in dimensions of...

The provision of aids and adaptations, risk assessments, and incident reporting and recording procedures in relation to injury prevention for adults with intellectual disabilities: cohort study
submitted by 992096 16 minutes ago - Topic: Health
Adults with intellectual disabilities (IDs) experience a higher incidence of injury, compared with the general population. The aim of this study was to investigate the provision of aids and adaptations, residential service providers' individual risk assessments and training in these, and injury incident recording and reporting procedures, in relation to injury prevention. MethodInterviews were ...

Genomic characterization of coxsackievirus type A24 strains associated with acute flaccid paralysis and rarely identified Hopkins syndrome
submitted by sahamplontotean 19 minutes ago - Topic: Health
The full-length genome sequence analysis of four coxsackievirus A24 (CV-A24) strains, detected in three paralytic and one post-asthmatic paralytic (Hopkins syndrome) cases, is reported here for the first time. A phylogenetic tree constructed on the basis of entire genomes displayed topology similar to that of the full-VP1 tree, classifying the study strains in genogroup CV-A24vGIV along with th...

Gp130-dependent signaling in the podocyte
submitted by choll3 22 minutes ago - Topic: Biology
Renal inflammation, in particular glomerular, is often characterized by increased IL-6 levels. The in vivo relevance of IL-6 signaling in glomerular podocytes, which play central roles in most glomerular diseases, is unknown. Here, we show that in normal mice, podocytes express gp130, the common signal-transducing receptor subunit of the IL-6 family of cytokines. Following systemic IL-6 or LPS ...



WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter
submitted by choll3 23 minutes ago - Topic: Biology
The serine/threonine kinase WNK3 and the ubiquitin-protein ligase NEDD4-2 are key regulators of the thiazide-sensitive Na+-Cl– cotransporter (NCC), WNK3 as an activator and NEDD2-4 as an inhibitor. Nedd4-2 was identified as an interacting partner of WNK3 through a glutathione-S-transferase pull-down assay using the N-terminal domain of WNK3, combined with LC-MS/MS analysis. This was valid...

Bilateral tibial lengthening over the nail: our experience of 143 cases
submitted by topeto 33 minutes ago - Topic: Health
Using lengthening over an intramedullary nail as a technique for cosmetic purposes improves the individuals’ quality of life and provides more satisfactory results due to less external fixator period. This study reports a case series of 143 individuals who underwent bilateral tibial lengthening over an intramedullary nail for cosmetic purposes together with the review of parameters related to...


Callus formation is related to the expression ratios of estrogen receptors-alpha and -beta in ovariectomy-induced osteoporotic fracture healing
submitted by topeto 33 minutes ago - Topic: Health
This study characterizes ovariectomized (OVX)-induced osteoporotic fracture healing with focus on estrogen receptors (ERs). Callus formation plays a critical role in fracture healing, and ERs are well-known mechanosensors in osteogenic pathways. It was hypothesized that callus formation was related to and partially determined by the difference in expression patterns of ERs in both normal and OV...

Eucalypts in Agroforestry, Reforestation, and Smallholders’ Conceptions of “Nativeness”: A Multiple Case Study of Plantation Owners in Eastern Paraguay
submitted by moksemgar 37 minutes ago - Topic: Forestry
Despite claims that plantations both enhance and undermine the quality, valuation and protection of natural forests, plantation forestry continues to expand worldwide. In Paraguay, changes in environmental policy, extension practices, and public perception of eucalypts (Eucalyptus spp.) have promoted a boom in plantation production of these species over the last 20 years. Smallholders, faced w...


The clinical analgesic efficacy of buprenorphine
submitted by nehetj 38 minutes ago - Topic: Health
ObjectiveBased on in vitro assays and select animal models, buprenorphine is commonly called a ‘partial agonist’. An implication is that it should produce less analgesic effect in humans than so-called ‘full agonists’ such as morphine or fentanyl. However, buprenorphine has a multimechanistic pharmacology, and thus partial agonism at a specific receptor is not particularly relevant to i...

‘Selective’ COX-1 or COX-2 NSAIDs: time to change a misleading measure
submitted by nehetj 38 minutes ago - Topic: Health
The ongoing important debate about the relative benefits/risks of COX-1 or COX-2 NSAIDs is hampered by the use of a measure of ‘selectivity’ that is inherently flawed. An alternative measure provides more meaningful and clinically relevant information.


An isolated middle cuneiform dislocation with a rare violence. Case report and literature review
submitted by ponyombele 42 minutes ago - Topic: Health
To report how a case of isolated middle cuneiform dislocation is diagnosed mainly by suspicion and careful imaging. A 39-year-old male presented with localized foot pain after a sideways compression of the foot on ground. X-rays revealed an empty middle cuneiform site . CT confirmed the finding of an isolated middle cuneiform dislocation . He had operative reduction and stabilization, followed ...

Is distal locking of long nails for intertrochanteric fractures necessary? A clinical study
submitted by ponyombele 42 minutes ago - Topic: Health
Few clinical studies have examined the utility of distal interlocking nails when fixing intertrochanteric fractures with intramedullary devices. In this study we performed a retrospective analysis comparing fixation method of intertrochanteric fractures with either a long unlocked cephalomedullary nail versus a long locked cephalomedullary nail. Our hypothesis was there would be no difference i...

Distribution of rotavirus strains and strain-specific effectiveness of the rotavirus vaccine after its introduction: a systematic review and meta-analysis
submitted by iddeiback2 43 minutes ago - Topic: Health
Concerns exist about whether monovalent (RV1) and pentavalent (RV5) rotavirus vaccines provide adequate protection against diverse strains and whether vaccine introduction will lead to selective pressure. We aimed to investigate the distribution of rotavirus strains and strain-specific rotavirus vaccine effectiveness after vaccine introduction. We did a systematic review of published work to as...

Motion patterns in activities of daily living: 3- year longitudinal follow-up after total shoulder arthroplasty using an optical 3D motion analysis system
submitted by ondyogon 48 minutes ago - Topic: Health
Total shoulder arthroplasty (TSA) can improve function in osteoarthritic shoulders, but the ability to perform activities of daily living (ADLs) can still remain impaired. Routinely, shoulder surgeons measure range of motion (ROM) using a goniometer. data are limited, however, concerning functional three-dimensional changes in ROM in ADLs after TSA in patients with degenerative glenohumeral ost...