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Three-dimensional tsunami propagation simulations using an unstructured mesh finite element model
submitted by rmocep 19 minutes ago - Topic: Geography
Large-scale tsunami propagation simulations from the fault region to the coast are conducted using a three-dimensional (3-D) parallel unstructured mesh finite element code (Fluidity-ICOM). Unlike conventional 2-D approximation models, our tsunami model solves the full 3-D incompressible Navier–...



Symmetry and the critical slip distance in rate and state friction laws
submitted by rmocep 19 minutes ago - Topic: Geography
We performed laboratory experiments to investigate the processes responsible for rate and state friction (RSF) behavior in fault rocks. We focus on symmetry of the friction constitutive response to velocity changes and the mechanics of the critical friction slip distance Dc. Experiments were cond...

Detection of short-term slow slip events along the Nankai Trough, southwest Japan using GNSS data
submitted by rmocep 19 minutes ago - Topic: Geography
We detected short-term slow slip events (SSEs) previously observable only with tilt and strain data along the Nankai Trough, southwest Japan using GNSS (Global Navigation Satellite System) data. Offsets detected in GNSS time series using Akaike's Information Criterion helped automatically identif...

Survey of European clinical geneticists on awareness, experiences and attitudes towards direct-to-consumer genetic testing
submitted by choll3 22 minutes ago - Topic: Biology
The advent of direct-to-consumer (DTC) genetic testing (GT) has sparked a number of debates regarding the scientific validity of tests, their broad health and ethical implications for society as well as their legal status. To date, relatively few empirical studies have been published regarding th...

Stepwise Ligand Exchange for the Preparation of a Family of Mesoporous MOFs
submitted by pporminteir 26 minutes ago - Topic: Agriculture
A stepwise ligand exchange strategy is utilized to prepare a series of isoreticular bio-MOF-100 analogues. Specifically, in situ ligand exchange with progressively longer dicarboxylate linkers is performed on single crystalline starting materials to synthesize products with progressively larger m...



Enantioselective Bromoaminocyclization of Allyl N-Tosylcarbamates Catalyzed by a Chiral Phosphine–Sc(OTf)3 Complex
submitted by pporminteir 26 minutes ago - Topic: Agriculture
An effective enantioselective bromoaminocyclization of allyl N-tosylcarbamates catalyzed by a chiral phosphine–Sc(OTf)3 complex is described. A wide variety of optically active oxazolidinone derivatives containing various functional groups can be obtained with high enantioselectivities....

Enhanced Photoluminescence of Sulfur-Bridged Organic Chromophores
submitted by pporminteir 26 minutes ago - Topic: Agriculture
A general approach to enhancing the emission quantum yield of several widely studied organic chromophores is presented. The luminescence properties of a series of symmetrical sulfur-bridged chromophores are reported as a function of the oxidation state of the bridging sulfur atom. The photolumine...

Nucleation-Controlled Polymerization of Nanoparticles into Supramolecular Structures
submitted by pporminteir 26 minutes ago - Topic: Agriculture
Controlled assembly of inorganic nanoparticles (NPs) into structurally defined supramolecular polymers will create nanomaterials with new collective properties. However, supramolecular polymerization of isotropic NPs remains a challenge because of the lack of anisotropic interactions in these mon...

Mn2(2,5-disulfhydrylbenzene-1,4-dicarboxylate): A Microporous Metal–Organic Framework with Infinite (−Mn–S−)∞ Chains and High Intrinsic Charge Mobility
submitted by pporminteir 26 minutes ago - Topic: Agriculture
The reaction of MnCl2 with 2,5-disulfhydrylbenzene-1,4-dicarboxylic acid (H4DSBDC), in which the phenol groups in 2,5-dihydroxybenzene-1,4-dicarboxylic acid (H4DOBDC) have been replaced by thiophenol units, led to the isolation of Mn2(DSBDC), a thiolated analogue of the M2(DOBDC) series of metal...

Long-Term Fluorescent Cellular Tracing by the Aggregates of AIE Bioconjugates
submitted by pporminteir 26 minutes ago - Topic: Agriculture
There is a great demand for long-term cellular tracers because of their great importance in monitoring biological processes, pathological pathways, therapeutic effects, etc. Herein we report a new type of fluorescence “turn-on” probe for tracing live cells over a long period of time. We synth...

Catalytic Activation of Carbohydrates as Formaldehyde Equivalents for Stetter Reaction with Enones
submitted by pporminteir 27 minutes ago - Topic: Agriculture
We disclose the first catalytic activation of carbohydrates as formaldehyde equivalents to generate acyl anions as one-carbon nucleophilic units for a Stetter reaction. The activation involves N-heterocyclic carbene (NHC)-catalyzed C–C bond cleavage of carbohydrates via a retro-benzoin-type pro...

Structural Alteration in the Pore Motif of the Bacterial 20S Proteasome Homolog HslV Leads to Uncontrolled Protein Degradation
submitted by ijo 28 minutes ago - Topic: Biology
In all cells, ATP-dependent proteases play central roles in the controlled degradation of short-lived regulatory or misfolded proteins. A hallmark of these enzymes is that proteolytic active sites are sequestered within a compartmentalized space, which is accessible to substrates only when they a...

Molecular Mechanism of Peroxisome Proliferator-activated Receptor α Activation by WY14643: a New Mode of Ligand Recognition and Receptor Stabilization
submitted by ijo 28 minutes ago - Topic: Biology
Peroxisome proliferator-activated receptors (PPARs) are members of a superfamily of nuclear transcription factors. They are involved in mediating numerous physiological effects in humans, including glucose and lipid metabolism. PPARα ligands effectively treat dyslipidemia, have significant anti-...

Targeting BCL2 Family in Human Myeloid Dendritic Cells: A Challenge to Cure Diseases with Chronic Inflammations Associated with Bone Loss
submitted by poddeikeoa 30 minutes ago - Topic: Health
Rheumatoid arthritis (RA) and Langerhans cell histiocytosis (LCH) are common and rare diseases, respectively. They associate myeloid cell recruitment and survival in inflammatory conditions with tissue destruction and bone resorption. Manipulating dendritic cell (DC), and, especially, regulating ...

What Are the Molecules Involved in Regulatory T-Cells Induction by Dendritic Cells in Cancer?
submitted by poddeikeoa 30 minutes ago - Topic: Health
Dendritic cells (DCs) are essential for the maintenance of homeostasis in the organism, and they do that by modulating lymphocyte priming, expansion, and response patterns according to signals they receive from the environment. The induction of suppressive lymphocytes by DCs is essential to hinde...




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