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Ivabradine Treatment in a Chronic Heart Failure Patient Cohort: Symptom Reduction and Improvement in Quality of Life in Clinical Practice
submitted by kotchin212 9 minutes ago - Topic: Health
In the prospective, open-label multicenter INTENSIFY study, the effectiveness and tolerability of ivabradine as well as its impact on quality of life (QOL) in chronic systolic heart failure (CHF) patients were evaluated over a 4-month period. In CHF patients with an indication for treatment with ivabradine, resting heart rate (HR), heart failure symptoms [New York Heart Association (NYHA) class...



Maternal hookworm modifies risk factors for childhood eczema: results from a birth cohort in Uganda
submitted by erfon241 10 minutes ago - Topic: Health
Worms may protect against allergy. Early-life worm exposure may be critical, but this has not been fully investigated. To investigate whether worms in pregnancy and in early childhood are associated with childhood eczema incidence. The Entebbe Mother and Baby Study, an anthelminthic treatment trial, enrolled pregnant women between 2003 and 2005 in Uganda. Mothers were investigated for worms dur...

Cross-sectional comparison of the characteristics of respiratory allergy in immigrants and Italian children
submitted by erfon241 10 minutes ago - Topic: Health
Immigrants represent a good epidemiological model to evaluate the relative influence of environmental and inherited factors on the development of allergy. Several studies on allergy in adults have been published, but few data in children are available. We aimed to investigate the differences, between Italian and immigrant children, in clinical characteristics of respiratory allergy. This was a ...

Exclusive breastfeeding is associated with reduced cow's milk sensitization in early childhood
submitted by erfon241 10 minutes ago - Topic: Health
Although breastfed infants have consistently been reported as having fewer infections and respiratory morbidity during infancy, none have reached a definitive conclusion as to whether breastfeeding is an effective strategy to prevent allergic diseases. This study aims to investigate the relationship between exclusive breastfeeding and sequential changes of several biomarkers of allergy, such as...

Comparison of Parabolic Filtration Methods for 3D Filtered Back Projection in Pulsed EPR Imaging
submitted by heghstrang 11 minutes ago - Topic: Health
Pulse electron paramagnetic resonance imaging (Pulse EPRI) is a robust method for noninvasively measuring local oxygen concentrations in vivo. For 3D tomographic EPRI, the most commonly used reconstruction algorithm is filtered back projection (FBP), in which the parabolic filtration process strongly influences image quality. In this work, we designed and compared 7 parabolic filtration methods...



Rapid Determination of Fluid Viscosity Using Low-Field Two-Dimensional NMR
submitted by heghstrang 11 minutes ago - Topic: Health
The rapid prediction of fluid viscosity, especially the fluid in heavy-oil petroleum reservoirs, is of great importance for oil exploration and transportation. We suggest a new method for rapid prediction of fluid viscosity using two-dimensional (2D) NMR relaxation time distributions. DEFIR, Driven-Equilibrium Fast-Inversion Recovery, a new pulse sequence for rapid measurement of 2D relaxation ...

A multi-purpose open-source triggering platform for magnetic resonance
submitted by heghstrang 11 minutes ago - Topic: Health
Many MR scans need to be synchronised with external events such as the cardiac or respiratory cycles. For common physiological functions commercial trigger equipment exists, but for more experimental inputs these are not available. This paper describes the design of a multi-purpose open-source trigger platform for MR systems. The heart of the system is an open-source Arduino Due microcontroller...


What makes a voice masculine: Physiological and acoustical correlates of women's ratings of men’s vocal masculinity
submitted by vectar 12 minutes ago - Topic: Biology
Men’s voices contain acoustic cues to body size and hormonal status, which have been found to affect women's ratings of speaker size, masculinity and attractiveness. However, the extent to which these voice parameters mediate the relationship between speakers' fitness-related features and listener’s judgments of their masculinity has not yet been investigated. We audio-recorded 37 adult het...

Acute exposure to 17α-ethinylestradiol alters boldness behavioral syndrome in female Siamese fighting fish
submitted by vectar 12 minutes ago - Topic: Biology
The role of anthropogenic sources in generating, maintaining, and influencing behavioral syndromes has recently been identified as an important area of future research. Endocrine disrupting chemicals are prevalent and persistent in aquatic ecosystems worldwide. These chemicals are known to have marked effects on the morphology and behavior of exposed individuals and, as such, may serve as a pot...


Integrating dilution-based sequencing and population genotypes for single individual haplotyping
submitted by chorlis 12 minutes ago - Topic: Biology
Haplotype information is useful for many genetic analyses and haplotypes are usually inferred using computational approaches. Among such approaches, the importance of single individual haplotyping (SIH), which infers individual haplotypes from sequence fragments, has been increasing with the advent of novel sequencing techniques, such as dilution-based sequencing. These techniques could produce...

Parallel selection on gene copy number variations through evolution of three-spined stickleback genomes
submitted by chorlis 12 minutes ago - Topic: Biology
Understanding the genetic basis of adaptive evolution is one of the major goals in evolutionary biology. Recently, it has been revealed that gene copy number variations (GCNVs) constitute significant proportions of genomic diversities within natural populations. However, it has been unclear whether GCNVs are under positive selection and contribute to adaptive evolution. Parallel evolution refer...


Inferring copy number and genotype in tumour exome data
submitted by chorlis 12 minutes ago - Topic: Biology
Using whole exome sequencing to predict aberrations in tumours is a cost effective alternative to whole genome sequencing, however is predominantly used for variant detection and infrequently utilised for detection of somatic copy number variation. :We propose a new method to infer copy number and genotypes using whole exome data from paired tumour/matched normal samples. Our algorithm uses two...

Serotype-conversion in Shigella flexneri: identification of a novel bacteriophage, Sf101, from a serotype 7a strain
submitted by chorlis 12 minutes ago - Topic: Biology
Shigella flexneri is the major cause of bacillary dysentery in the developing countries. The lipopolysaccharide (LPS) O-antigen of S. flexneri plays an important role in its pathogenesis and also divides S. flexneri into 19 serotypes. All the serotypes with an exception for serotype 6 share a common O-antigen backbone comprising of N-acetylglucosamine and three rhamnose residues. Different sero...

Characterization of the core and accessory genomes of Pseudomonas aeruginosa using bioinformatic tools spine and AGEnt
submitted by chorlis 12 minutes ago - Topic: Biology
Pseudomonas aeruginosa is an important opportunistic pathogen responsible for many infections in hospitalized and immunocompromised patients. Previous reports estimated that approximately 10% of its 6.6 Mbp genome varies from strain to strain and is therefore referred to as "accessory genome." Elements within the accessory genome of P. aeruginosa have been associated with differences in virulen...

Rapid transcriptome sequencing of an invasive pest, the brown marmorated stink bug Halyomorpha halys
submitted by chorlis 12 minutes ago - Topic: Biology
Halyomorpha halys (Stal) (Insecta:Hemiptera;Pentatomidae), commonly known as the Brown Marmorated Stink Bug (BMSB), is an invasive pest of the mid-Atlantic region of the United States, causing economically important damage to a wide range of crops. Native to Asia, BMSB was first observed in Allentown, PA, USA, in 1996, and this pest is now well-established throughout the US mid-Atlantic region ...