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Imaging of skeletal extremity trauma: A review
submitted by esobil 8 minutes ago - Topic: Health
Successful treatment of trauma to the skeletal system begins with accurate diagnosis, which entails the need for a thorough clinical assessment in addition to a well-performed and correctly interpreted radiographic examination. The physician dealing with skeletal trauma should be aware that certain activities (falls, sports, etc.) lead to particular types of limb injury as well as the fact that...



Prestimulus theta in the human hippocampus predicts subsequent recognition but not recall
submitted by chorlis 15 minutes ago - Topic: Health
Human theta (4−8 Hz) activity in the medial temporal lobe correlates with memory formation; however, the precise role that theta plays in the memory system remains elusive (Hanslmayr and Staudigl, 2013). Recently, prestimulus theta activity has been associated with successful memory formation, although its specific cognitive role remains unknown (e.g. Fell et al., 2011). In this report, we de...

Bisphenol A regulates the estrogen receptor alpha signaling in developing hippocampus of male rats through estrogen receptor
submitted by chorlis 15 minutes ago - Topic: Health
Bisphenol A (BPA), one of the most common environmental endocrine disruptors, has been recognized to have wide adverse effects on the brain development and behavior. These adversities are related to its ability to bind estrogen receptor (ER) with subsequent alteration of its expression in the target areas. However, very little is known about whether BPA exposure also affects ER phosphorylation ...

Reflection of oblique ocean water waves by a vertical porous structure placed on a multi-step impermeable bottom
submitted by swopnelorvi 15 minutes ago - Topic: Geography
Based on linear water wave theory, wave reflection by a vertical porous structure placed on an elevated impermeable seabed, assumed to consist of a number of horizontal steps, is considered. The reflection phenomenon is investigated for two forms of the bottom topography: first a 2-step one and then a p-step one. An oblique incident wave propagates through the porous structure and gets reflecte...

Transcription factors and glyoxylate cycle genes prominent in the transition of soybean cotyledons to the first functional leaves of the seedling
submitted by foizihkofe 22 minutes ago - Topic: Biology
During early seedling growth, the cotyledons transition from a storage tissue to become effectively the first leaf-like structures of the plant. In this programmed developmental process, they likely undergo a massive change in gene expression to redirect their metabolism and physiological processes. To define the developmental shifts in gene expression and begin to understand the gene regulator...



The Journey to Diagnosis in AS/Axial SpA: The Impact of Delay
submitted by sothyo 24 minutes ago - Topic: Health
The aim of the present study was to conduct an in-depth exploration of the ‘journey’ to diagnosis of people with ankylosing spondylitis (AS)/axial spondyloarthritis (Axial SpA) to gain insights into the experience, potential barriers and facilitators in this process. The present qualitative study, embedded within a prospective longitudinal cohort study, was located within an interpretive ph...

Individual and environmental effects on egg allocations of female Greater Sage-Grouse
submitted by vencieadeco 34 minutes ago - Topic: Biology
The average number of eggs in a clutch and the size of those eggs play a role in individual fitness. We explored sources of variation in egg allocations of female Greater Sage-Grouse (Centrocercus urophasianus) in the American Great Basin over a 10-yr period, as well as range-wide variation in clutch size, using our data and other published values. We tested for environmental and individual eff...


Radionuclide determination and radioactivity evaluation of surface soil samples collected along the Erçek Lake basin in eastern Anatolia, Turkey
submitted by deono2119 58 minutes ago - Topic: Geography
In the present study, the mean activity concentrations of 238U, 232Th, 40 K and fission products 137Cs in the soil samples measured by using high-purity germanium gamma spectrometry were 18.9, 27.2, 524.0 and 10.6Bqkg−1, respectively. The activity results were analyzed for frequency distribution, tabulated and compared with Turkey and worldwide literatures. Radiological risk evaluation was do...

Soil contamination near a former Zn-Pb ore-treatment plant: Evaluation of deterministic factors and spatial structures at the landscape scale
submitted by deono2119 58 minutes ago - Topic: Geography
Historical soil contamination within a 3km radius of a former ore treatment plant was evaluated. A total of 247 topsoil samples were collected in a stratified random sampling design taking into account three factors: land use (LU), soil type (ST) and wind direction (WD). Concentrations of trace elements (Cd, Co, Cr, Cu, Ni, Pb and Zn) and major elements (Ca, Mg, K, Fe, Al, Mn) as well as variou...


Autologous Fat Grafting for Breast Augmentation in Underweight Women
submitted by ondriries00 1 hour ago - Topic: Health
In recent years, there have been reports of success with autologous fat grafting to the breast for cosmetic breast enhancement. However, the procedure is generally contraindicated in women who are underweight (body mass index [BMI] 18.5) or group B (BMI ≤18.5; underweight). A retrospective analysis was performed to compare the safety and effectiveness of fat grafting between the study groups...

Breast Striae After Cosmetic Augmentation
submitted by ondriries00 1 hour ago - Topic: Health
Breast augmentation is the most popular cosmetic surgery procedure in the United States. Postoperative striae is a known but incompletely understood complication of breast augmentation. The authors investigated their own patient population to discern risk factors for new-onset striae after cosmetic breast augmentation. A retrospective chart review was performed for patients who underwent primar...


Improvement in Stress Urinary Incontinence After Abdominoplasty
submitted by ondriries00 1 hour ago - Topic: Health
Abdominoplasty is indicated in cosmetic surgery to improve body contour. from several studies suggest that abdominoplasty also could be therapeutic for certain individuals with urinary incontinence. The authors sought to determine the potential therapeutic effect of abdominoplasty on urinary incontinence in a large population to confirm the findings of smaller studies and to identify common cha...

Time- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral Changes
submitted by mateishori 1 hour ago - Topic: Biology
Cilengitide is a stable cyclic pentapeptide containing an Arg-Gly-Asp motif responsible for selective binding to αVβ3 and αVβ5 integrins. The candidate drug showed unexpected inhibition of cytochrome P450 (P450) 3A4 at high concentrations, that is, a 15-mM concentration caused attenuation of P450 3A4 activity (depending on the probe substrate): 15–19% direct inhibiti...

Identification and Functional Characterization of Novel Nonsynonymous Variants in the Human Multidrug and Toxin Extrusion 2-K
submitted by mateishori 1 hour ago - Topic: Biology
This study was performed to identify genetic polymorphisms in multidrug and toxin extrusion 2-K (MATE2-K, SLC47A2), a proton/organic cation antiporter that plays a role in the transport of organic cations across the apical membrane in kidney epithelial cells into the urine, and to demonstrate their effects on MATE2-K functions in vitro. Four of the thirty single nucleotide polymorphisms (SNPs) ...

Calibration of In Vitro Multidrug Resistance Protein 1 Substrate and Inhibition Assays as a Basis to Support the Prediction of Clinically Relevant Interactions In Vivo
submitted by mateishori 1 hour ago - Topic: Biology
The multidrug resistance protein 1 (MDR1) is known to limit brain penetration of drugs and play a key role in drug-drug interactions (DDIs). Theoretical cut-offs from regulatory guidelines are used to extrapolate MDR1 interactions from in vitro to in vivo. However, these cut-offs do not account for interlaboratory variability. Our aim was to calibrate our experimental system to allow better in ...