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A common microdeletion affecting a hippocampus- and amygdala-specific isoform of tryptophan hydroxylase 2 is not associated with affective disorders
submitted by tetas2095 7 minutes ago - Topic: Health
Copy number variants (CNVs) have been shown to affect susceptibility for neuropsychiatric disorders. To date, studies implicating the serotonergic system in complex conditions have just focused on single nucleotide polymorphisms (SNPs). We therefore sought to identify novel common genetic copy number polymorphisms affecting genes of the serotonergic system, and to assess their putative role in ...



Morphological and cytological observations of wild species and hybrids of Gypsophila
submitted by j5onjin 8 minutes ago - Topic: Biology
Gypsophilapaniculata L. is among the 10 best selling cut flower species globally and is considered a “target” plant for breeding varieties. The aim of this work was to make the genetic improvement of Gypsophila more rational and focused. The study of basic chromosome number and the reproductive system (potential barriers to intraspecific and interspecific incompatibilities) of the wild spec...

Comparison of the growth of filamentous fungi and yeasts in lignocellulose-derived media
submitted by welcos3221 10 minutes ago - Topic: Agriculture
Five microorganisms of potential interest for on-site enzyme production in lignocellulosic biorefineries were evaluated with regard to inhibitor tolerance and nutrient utilization. Prehydrolysate and hydrolysate of Norway spruce were used in concentrations of 25%, 50%, 75% and 100% and compared to reference media without fermentation inhibitors. Monosaccharide sugars, oligosaccharides, and smal...

New data of early Late Ordovician chitinozoans from the Miaopo Formation at Jieling, Yichang, central China
submitted by caalam2 11 minutes ago - Topic: Geography
Chitinozoans from the uppermost Darriwilian–lower Sandbian Miaopo Formation at Jieling of western Hubei Province are reported, for the first time, including 30 species of 14 genera from 10 collections which are much more diverse and abundant than previously known. Two chitinozoan assemblages are recognized: the Laufeldochitina cf. striata Assemblage and the Eisenackitina cf. rhenana Assemblag...

Varved glaciomarine clay in central Sweden before and after the Baltic Ice Lake drainage: a further clue to the drainage events at Mt Billingen
submitted by caalam2 12 minutes ago - Topic: Geography
Glaciomarine clay found west of Mt Billingen, central Sweden, contains two distinct varve units separated by a sand layer that we interpret to be sediment deposited in the North Sea during the catastrophic drainage of the Baltic Ice Lake (BIL). The lower varve series was deposited proximal to the retreating ice margin and consists of varves that grade upward from gray to red. The upper varve se...



Flow–structure–seabed interactions in coastal and marine environments
submitted by dpspiocack 12 minutes ago - Topic: Environment
Flow–structure–seabed interaction in coastal and marine environments is a rapidly growing area of research and applications. In this vision paper, this area is discussed with a view of identifying its state of the art and current research challenges. The discussion draws attention to key issues related to structures such as marine pipelines, offshore windfarms, and multiuse offshore platfor...

Autoimmune liver disease: Novelties in management
submitted by pheleppi 15 minutes ago - Topic: Health
Autoimmune liver disease is the second commonest cause of chronic liver disease in teenagers. There are several forms including autoimmune hepatitis, autoimmune sclerosing cholangitis, primary sclerosing cholangitis and various overlap syndromes, classified on the basis of different serum antibody profiles, histological features and appearances on cholangiography. Treatment with immunosupressan...


Dual echo vessel-encoded ASL for simultaneous BOLD and CBF reactivity assessment in patients with ischemic cerebrovascular disease
submitted by ponyombele 15 minutes ago - Topic: Health
Blood oxygenation level-dependent (BOLD)-weighted and vessel-encoded arterial spin labeling (VE-ASL) MRI provide complementary information and can be used in sequence to gauge hemodynamic contributions to cerebrovascular reactivity. Here, cerebrovascular reactivity is assessed using dual echo VE-ASL MRI to understand how VE labeling preparations influence BOLD and ASL contrast in flow-limited a...

Low-rank plus sparse matrix decomposition for accelerated dynamic MRI with separation of background and dynamic components
submitted by ponyombele 15 minutes ago - Topic: Health
To apply the low-rank plus sparse (L+S) matrix decomposition model to reconstruct undersampled dynamic MRI as a superposition of background and dynamic components in various problems of clinical interest. Theory and MethodsThe L+S model is natural to represent dynamic MRI data. Incoherence between k-t space (acquisition) and the singular vectors of L and the sparse domain of S is required to re...


Accelerated dual-contrast first-pass perfusion MRI of the mouse heart: Development and application to diet-induced obese mice
submitted by ponyombele 15 minutes ago - Topic: Health
Gene-modified mice may be used to elucidate molecular mechanisms underlying abnormal myocardial blow flow (MBF). We sought to develop a quantitative myocardial perfusion imaging technique for mice and to test the hypothesis that myocardial perfusion reserve (MPR) is reduced in a mouse model of diet-induced obesity (DIO). A dual-contrast saturation-recovery sequence with ky-t undersampling and a...

Social interactions and malaria preventive behaviors in sub-saharan africa
submitted by tormik97 19 minutes ago - Topic: Health
This paper examines the existence of social interactions in malaria preventive behaviors in Sub-Saharan Africa, that is, whether an individual's social environment has an influence on the individual's preventive behaviors. We focus on the two population groups which are the most vulnerable to malaria (children under 5 years and pregnant women) and on two preventive behaviors (sleeping under a...


The inhibition of RANK-ligand in the management of postmenopausal osteoporosis and related fractures: the role of denosumab
submitted by gseikmon 21 minutes ago - Topic: Health
There is great interest in new treatments of osteoporosis owing to general ageing of population and increased risk for fragility fractures in the elderly. Current therapies show a good efficacy in improving bone quality and bone density, but, in spite of a certain reduction in fracture rate, according to each treatment, the problem of osteoporotic fractures is yet far from to be solved. Moreove...

Carbon and nitrogen fluxes between beech and their ectomycorrhizal assemblage
submitted by esmoil 21 minutes ago - Topic: Agriculture
To determine the exchange of nitrogen and carbon between ectomycorrhiza and host plant, young beech (Fagus sylvatica) trees from natural regeneration in intact soil cores were labelled for one growing season in a greenhouse with 13CO2 and 15NO315NH4. The specific enrichments of 15N and 13C were higher in ectomycorrhizas (EMs) than in any other tissue. The enrichments of 13C and 15N were also hi...

Tuber aestivum association with non-host roots
submitted by esmoil 21 minutes ago - Topic: Agriculture
Mycorrhizal fungi provide direct and functional interconnection of soil environment with their host plant roots. Colonization of non-host plants have occasionally been described, but its intensity and functional significance in complex plant communities remain generally unknown. Here, the abundance of ectomycorrhizal fungus Tuber aestivum was measured in the roots of host and non-host (non-ecto...

An NRAS mutation in a case of Erdheim Chester disease
submitted by mecralrimideis 22 minutes ago - Topic: Health
Erdheim Chester disease (ECD) is a rare, non-Langerhans’ cell histiocytic neoplastic disorder that usually presents in patients in their fifties. ECD often presents as a multi-system macrophagic infiltration and common sites of involvement are the central nervous system, cardiovascular system, respiratory system, retroperitoneum, and skin. Extra-skeletal involvement is usually responsible for...