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The perspectives of Aboriginal patients and their health care providers on improving the quality of hemodialysis services: A qualitative study
submitted by geriishkoyyar 27 minutes ago - Topic: Health
Chronic kidney disease has a higher prevalence in Indigenous populations globally. The incidence of end-stage kidney disease in Australian Aboriginal people is eight times higher than non-Aboriginal Australians. Providing services to rural and remote Aboriginal people with chronic disease is challenging because of access and cultural differences. This study aims to describe and analyze the pers...



Influence of season and organ on antibacterial activity of Magnolia dealbata Zucc. against two phytopathogenic bacteria
submitted by mnasawetz 39 minutes ago - Topic: Biology
As an alternative to reduce the use of agrochemicals, plant extracts can be a better choice in the control of phytopathogens. In this study, we tested the effects of Magnolia dealbata Zucc. crude extracts on the bacterial growth of Pectobacterium carotovorum and Pseudomonas cichorii, both micro-organisms of phytopathogenic relevance. In addition, our other aim was to explain the influence of th...

Streptococcus mitis/oralis endophthalmitis management without phakic intraocular lens removal in patient with iris-fixated phakic intraocular lens implantation
submitted by samonothco 54 minutes ago - Topic: Health
To report a case of Streptococcus mitis/oralis endophthalmitis management which had developed after complicated iris-fixated phakic intraocular (pIOL) lens implantation. A 23-year-old-woman received pIOL implantation followed secondary intraocular intervention to lower intraocular pressure. The patient presented with severe pain and decreased visual acuity and was managed with intravitreal and ...

What factors influence concordance with medications? Findings from the UK Asian Diabetes study
submitted by xchenanex 1 hour ago - Topic: Health
To investigate concordance with medication, as assessed at baseline and at 1- and 2-year follow-up, and to examine factors associated with non-concordance in a UK-resident South-Asian population. Data from the UK Asian Diabetes Study were analysed. Concordance with medications was assessed and recorded at three time points during the study. Multiple logistic regression was used to investigate t...

Role of sleep duration as a risk factor for Type 2 diabetes among adults of different ages in Japan: the Niigata Wellness Study
submitted by xchenanex 1 hour ago - Topic: Health
To compare the role of short sleep duration as a risk factor for diabetes among adults of different ages. The study enrolled 38987 Japanese individuals without diabetes, and the 8-year risk of developing diabetes attributable to different sleep durations (...



Impact of deferred grazing and fertilizer on herbage production, soil seed reserve and nutritive value of native pastures in steep hill country of southern Australia
submitted by ritmon 1 hour ago - Topic: Agriculture
Developing sustainable grazing management systems based on perennial species is critical to preventing land degradation in marginal land classes. A field study was conducted from 2002 to 2006 to identify the impacts of deferred grazing (no defoliation of pastures for a period generally from spring to autumn) and fertilizer application on herbage accumulation, soil seed reserve and nutritive val...

Functional elucidation of antibacterial phage ORFans targeting Pseudomonas aeruginosa
submitted by vejoykamor 1 hour ago - Topic: Biology
Immediately after infection, virulent bacteriophages hijack the molecular machinery of their bacterial host to create an optimal climate for phage propagation. For the vast majority of known phages, it is completely unknown which bacterial functions are inhibited or coopted. Early expressed phage genome regions are rarely identified, and often filled with small genes with no homology in databas...


Phosphoinositides and Engulfment
submitted by vejoykamor 1 hour ago - Topic: Biology
Cellular engulfment of particles, cells or solutes displaces large domains of plasma membrane into intracellular membranous vacuoles. This transfer of membrane is accompanied by major transitions of the phosphoinositide (PI) species that comprise the cytoplasmic face of membrane bilayers. Mapping of membrane PIs during engulfment reveals distinct patterns of protein and PI distributions associa...

Pediatric medial epicondyle fractures with intra-articular elbow incarceration
submitted by motgerl 1 hour ago - Topic: Health
Intra-articular incarceration of the epicondylar fragment occurs in 5–18 % of all cases of medial epicondyle fracture. It requires stable fixation to allow early motion, since elbow stiffness is the most common complication following medial epicondyle fracture. In this retrospective study, we report the clinical and functional outcomes and the complications that occurred following open reduc...


Effect of iron deficiency on the expression of insulin-like growth factor-II and its receptor in neuronal and glial cells
submitted by mahonbintar 1 hour ago - Topic: Health
Many studies have demonstrated that iron deficiency modifies the normal function of the central nervous system (CNS) and alters cognitive abilities. When cellular damage occurs in the CNS, neuroprotective mechanisms, such as the production of neurotrophic factors, are essential in order for nervous tissue to function correctly. Insulin-like growth factor II (IGF-II) is a neurotrophic factor tha...

Cranial trepanation in The Egyptian
submitted by mahonbintar 1 hour ago - Topic: Health
Medicine and literature have been linked from ancient times; proof of this shown by the many doctors who have been dedicated to literature and many writers have described medical activities and illnesses in their works. An example is Sinuhe, the Egyptian from the work of Mika Waltari that masterly narrates the medical activity of the protagonist and describes the trepanation technique. The pres...


Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27 (H3K27me3): Another poor prognostic phenotype independent of c-Myc/Bcl2co-expression
submitted by morc 2 hours ago - Topic: Health
Deregulation of histone H3 trimethylation at lysine 27 (H3K27me3) via aberration of the histone methyltransferase, enhancer of zeste homologue 2 (EZH2), is suggested to play a critical role in cancers including hematologic malignancies. In the present study, implications of H3K27me3 were investigated in diffuse large B-cell lymphoma (DLBCL) with respect to clinico-pathological factors, especial...

ARID1A Immunohistochemistry Improves Outcome Prediction In Invasive Urothelial Carcinoma of Urinary Bladder
submitted by morc 2 hours ago - Topic: Health
AT-rich interactive domain 1A (ARID1A) is tumor suppressor gene that interacts with BRG1 ATPase to form a SWI/SNF chromatin remodeling protein complex. Inactivation of ARID1A has been described in several neoplasms, including epithelial ovarian and endometrial carcinomas, and has been correlated with prognosis. In the current study, ARID1A expression in urothelial carcinoma (UC) of the bladder ...

How reliable is immunohistochemical staining for DNA mismatch repair proteins performed after neoadjuvant chemoradiation?
submitted by morc 2 hours ago - Topic: Health
Immunohistochemistry (IHC) testing for mismatch repair proteins (MMRP) is currently being used primarily in colorectal cancer resection specimens. We aimed to compare the results of IHC staining performed on biopsy specimens obtained at endoscopy with that performed on surgical specimens following neoadjuvant therapy. Thirty-two rectal cancer subjects had paired pre- and post-neoadjuvant tissue...

Low Grade Neuroendocrine Tumors Arising in Intestinal Adenomas: evidence for Alterations in the APC/β-catenin Pathway
submitted by morc 2 hours ago - Topic: Health
Low grade neuroendocrine tumors (NETs) arising in intestinal adenomas are rare. They are occasionally observed in patients with familial adenomatous polyposis (FAP), suggesting a role for the adenomatous polyposis coli (APC)/β-catenin pathway. We identified 25 composite adenoma/low grade NETs from colorectum (21) and duodenum and evaluated their clinicopathologic features, survival, and nuclea...