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Dysanapsis Ratio as a Predictor for Expiratory Flow Limitation
submitted by 14 minutes ago - Topic: Health
To determine the efficacy of the dysanapsis ratio (DR) in predicting expiratory flow limitation during exercise, 146 subjects (73 men, 73 women) performed standard pulmonary function and maximal incremental exercise tests. Tidal flow-volume loops were recorded at maximal exercise with maximal flow-volume loops measured pre- and post-exercise. Men had larger (p<0.05) lung volumes,flow rat...



Assessment of acute bronchodilator effects from specific airway resistance changes in stable COPD patients
submitted by 14 minutes ago - Topic: Health
In COPD patients, reversibility is currently evaluated from the changes of forced expiratory volume at 1s (ΔFEV1) and forced vital capacity (ΔFVC). By lowering peripheral airway smooth muscle tone, bronchodilators should decrease dynamic hyperinflation, gas trapping, and possibly dyspnea at rest. Hence, we hypothesize that specific airway resistance changes (ΔsRAW) should better characterize...

Breathing hot humid air induces airway irritation and cough in patients with allergic rhinitis
submitted by 14 minutes ago - Topic: Health
We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4min of humidified hot air (HA; 49°C) and room air (RA: 21°C) were compared between AR patients (n =7) and healthy subjects (n =6). In AR patients, cough frequency increased pronouncedly from 0.10...

Diaphragmatic neuromechanical coupling and mechanisms of hypercapnia during inspiratory loading
submitted by 14 minutes ago - Topic: Health
We hypothesized that improved diaphragmatic neuromechanical coupling during inspiratory loading is not sufficient to prevent alveolar hypoventilation and task failure, and that the latter results primarily from central-output inhibition of the diaphragm and air hunger rather than contractile fatigue. Eighteen subjects underwent progressive inspiratory loading. By task failure all developed hype...

Indigenous African building techniques and the prospects for sustainable housing and environmental development
submitted by 14 minutes ago - Topic: Environment
In this paper, sustainability is examined as one of the objectives of enabling man in a preserved, efficient and enduring world environment. Thus, sustainable housing and environmental development is conceptualized as a building or shelter provided through judicious, selective sourcing, processing and use of building materials to satisfy current shelter needs while ensuring quality environment ...



An assessment of the metabolic profile implied by agricultural change in two rural communities in the North of Argentina
submitted by 14 minutes ago - Topic: Environment
The soy expansion model in Argentina generates structural changes in traditional lifestyles, which can be associated with different biophysical and socioeconomic impacts. To explore this issue, we apply an innovative method for integrated assessment—the multi-scale integrated analysis of societal and ecosystem metabolism framework—to characterize two communities in the Chaco Region, Provinc...

Water use in arid rural systems and the integration of water and agricultural policies in Europe: the case of Andarax river basin
submitted by 14 minutes ago - Topic: Environment
Water is a precious resource in arid rural areas with irrigated agriculture. Nonetheless, water and agricultural policies in Europe show different management scopes , usually translated in divergent drivers of rural change. This paper has a double aim: to propose a specific method for quantitative biophysical analysis of water use in rural systems with the multi-scale integrated analysis of soc...


Integrating energy and land-use planning: socio-metabolic profiles along the rural–urban continuum in Catalonia (Spain)
submitted by 14 minutes ago - Topic: Environment
Abandoning fossil fuels and increasingly relying on low-density, land-intensive renewable energy will increase demand for land, affecting current global and regional rural–urban relationships. Over the past two decades, rural–urban relationships all over the world have witnessed unprecedented changes that have rendered their boundaries blurred and have lead to the emergence of “new rurali...

Antiplatelet Therapy for Stable Coronary Artery Disease in Atrial Fibrillation Patients Taking an Oral Anticoagulant: A Nationwide Cohort Study
submitted by 14 minutes ago - Topic: Health
The optimal long-term antithrombotic treatment of patients with coexisting atrial fibrillation and stable coronary artery disease is unresolved, and commonly, a single antiplatelet agent is added to oral anticoagulation. We investigated the effectiveness and safety of adding antiplatelet therapy to vitamin K antagonist (VKA) in atrial fibrillation patents with stable coronary artery disease. an...


Aldose Reductase-Mediated Phosphorylation of p53 Leads to Mitochondrial Dysfunction and Damage in Diabetic Platelets
submitted by 14 minutes ago - Topic: Health
Platelet abnormalities are well-recognized complications of diabetes mellitus. Mitochondria play a central role in platelet metabolism and activation. Mitochondrial dysfunction is evident in diabetes mellitus. The molecular pathway for hyperglycemia-induced mitochondrial dysfunction in platelets in diabetes mellitus is unknown. and Results-Using both human and humanized mouse models, we report ...

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis
submitted by 14 minutes ago - Topic: Health
Intimal smooth muscle cells (SMCs) contribute to the foam cell population in arterial plaque, and express lower levels of the cholesterol exporter ATP-binding cassette transporter A1 (ABCA1) in comparison with medial arterial SMCs. The relative contribution of SMCs to the total foam cell population and their expression of ABCA1 in comparison with intimal monocyte-derived macrophages, however, a...


Early Adult to Midlife Cardiovascular Risk Factors and Cognitive Function
submitted by 14 minutes ago - Topic: Health
Studies have linked midlife and late-life cardiovascular risk factors (CVRFs) to cognitive function, yet little is known about CVRF exposure in early adulthood and subsequent cognitive function. In addition, most studies rely on single assessments of CVRFs, which may not accurately reflect long-term exposure. We sought to determine the association between cumulative exposure to CVRFs from early...

Variations in Cause and Management of Atrial Fibrillation in a Prospective Registry of 15 400 Emergency Department Patients in 46 Countries: The RE-LY Atrial Fibrillation Registry
submitted by 14 minutes ago - Topic: Health
Atrial fibrillation (AF) is the most common sustained arrhythmia; however, little is known about patients in a primary care setting from high-, middle-, and low-income countries. and Results-This prospective registry enrolled patients presenting to an emergency department with AF at 164 sites in 46 countries representing all inhabited continents. Patient characteristics were compared among 9 ma...

Cytomorphology of non-small cell lung carcinoma with anaplastic lymphoma kinase gene rearrangement
submitted by 14 minutes ago - Topic: Health
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase demonstrating activating mutations in several malignancies including a subset (1–5%) of non-small cell lung carcinomas (NSCLC). Prior work examining, the histologic features of these tumors found a spectrum of findings, notably a solid/acinar pattern, as well as a mucinous cribriform pattern. We present the first study to date des...

Fine needle aspiration cytology of a myoepithelioma presenting as a thyroid nodule
submitted by 14 minutes ago - Topic: Health
Myoepitheliomas are rare neoplasms that are typically found in the major and minor salivary glands and represent approximately 1.5% of all salivary gland neoplasms. We present a patient with an exophytic anterior midline neck mass, which was initially believed to be a thyroid isthmus nodule that underwent fine needle aspiration (FNA) biopsy. FNA cytologic evaluation reveals numerous plump spind...

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