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A multicenter, open-label, phase 2 study of lenalidomide plus low-dose dexamethasone in Chinese patients with relapsed/refractory multiple myeloma: the MM-021 trial
submitted by iffeik 15 minutes ago - Topic: Health
There is an unmet need for treatment options in Chinese patients with relapsed or refractory multiple myeloma (RRMM). Lenalidomide plus low-dose dexamethasone is effective and generally well tolerated in Caucasian RRMM patients, but no previous study has evaluated this regimen in Chinese RRMM pat...



Estimation of carbonate, total organic carbon, and biogenic silica content by FTIR and XRF techniques in lacustrine sediments
submitted by ogradivca 15 minutes ago - Topic: Geography
Major components of lacustrine sediments, such as carbonates, organic matter, and biogenic silica, provide significant paleoenvironmental information about lake systems. Fourier transform infrared spectroscopy (FTIR) and scanning X-ray fluorescence (XRF) techniques are fast, cost effective, effic...

Pollen, phytoliths, arthropods and high-resolution 14C sampling from Rano Kau, Easter Island: evidence for late Quaternary environments, ant (Formicidae) distributions and human activity
submitted by ogradivca 15 minutes ago - Topic: Geography
A 20-m sediment core from Rano Kau, Easter Island provides plant microfossil, arthropod fossil and high-resolution 14C sampling evidence for late Quaternary environments, ant (Formicidae) distributions and human activity. The record commences prior to or during the LGM, providing the two oldest d...

Lessons about terminal differentiation from the specification of color-detecting photoreceptors in the Drosophila retina
submitted by corlahomilenck 16 minutes ago - Topic: Biology
Metazoans require highly diverse collections of cell types to sense, interpret, and react to the environment. Developmental programs incorporate deterministic and stochastic strategies in different contexts or different combinations to establish this multitude of cell fates. Precise genetic disse...

Optimization of sperm irradiation protocol for induced gynogenesis in Siberian sturgeon, Acipenser baerii
submitted by bregetti 17 minutes ago - Topic: Agriculture
The great diversity of optimal UV irradiation doses are used for DNA inactivation in fish sperm forcing authors to repeat optimization of irradiation treatment every time. Analysis of sperm UV irradiation protocol for induction of gynogenesis showed the importance of sperm UV light absorption est...



Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort
submitted by forilolefeyoh 19 minutes ago - Topic: Health
Comorbidities, are common in COPD, have been associated with poor outcomes and are thought to relate to systemic inflammation. To investigate comorbidities in relation to systemic inflammation and outcomes we recorded comorbidities in a well characterized cohort (ECLIPSE study) for 2164 clinicall...

Fibrosing interstitial pneumonia predicts survival in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD)
submitted by forilolefeyoh 19 minutes ago - Topic: Health
Rheumatoid arthritis (RA) is a systemic autoimmune disorder with a variety of extra-articular manifestations. The lung is a common target and diffuse parenchymal lung disease can appear as any of the patterns found with idiopathic interstitial pneumonia. Controversy exists as to the prognostic si...

Overexpression of the Polycystin-1 C-Tail Enhances Sensitivity of M-1 Cells to Ouabain
submitted by majtobo3521 20 minutes ago - Topic: Biology
Cells derived from renal cysts of patients with autosomal dominant polycystic kidney disease (ADPKD) are abnormally sensitive to ouabain, responding to physiological ouabain concentrations with enhanced proliferation and increased forskolin-induced transepithelial fluid secretion. This requires a...

Subcellular Localization and Kinetic Characterization of a Gill (Na+, K+)-ATPase from the Giant Freshwater Prawn Macrobrachium rosenbergii
submitted by majtobo3521 20 minutes ago - Topic: Biology
The stimulation by Mg2+, Na+, K+, NH4+, and ATP of (Na+, K+)-ATPase activity in a gill microsomal fraction from the freshwater prawn Macrobrachium rosenbergii was examined. Immunofluorescence labeling revealed that the (Na+, K+)-ATPase α-subunit is distributed predominantly within the intralamel...

Mislabeled: eco-labeling an invasive alien shellfish fishery
submitted by krsch 23 minutes ago - Topic: Biology
The invasive alien Manila clam fishery from Ria Arousa, Spain, was recommended for a Marine Stewardship Council certificate which implies the fishery maintains the integrity of the ecosystem. By certifying an environmentally harmful invasive alien clam fishery, the MSC harms the environment and r...

Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat
submitted by gono3119 25 minutes ago - Topic: Health
Diabetic encephalopathy (DE) has been characterized by the impaired cognition and the abnormalities of neurochemistry and neurostructure. The study was conducted to evaluate the neuroprotective effect of paeonol on STZ-induced DE rats. Paeonol of 25, 50, 100mg/kg (p.o.) could decrease the latency...

Intoxications with the monoamine oxidase inhibitor tranylcypromine: An analysis of fatal and non-fatal events
submitted by obdole3113 33 minutes ago - Topic: Health
Tranylcypromine (TCP) is a non-selective and irreversible monoamine oxidase inhibitor and an effective agent in the treatment of major depression. It features a complex pharmacologic profile and overdoses might induce severe intoxications. To identify typical clinical presentations of TCP-intoxic...

Intimate Partner Violence and Antiretroviral Adherence Among Women Receiving Care in an Urban Southeastern Texas HIV Clinic
submitted by ssshet 35 minutes ago - Topic: Health
This nonexperimental, descriptive study examined relationships between recent intimate partner violence (IPV) and antiretroviral therapy (ART) adherence among women. Data from 272 HIV-infected women receiving care at a large HIV clinic were obtained through interviews and medical record abstracti...

Unique Factors that Place Older Hispanic Women at Risk for HIV: Intimate Partner Violence, Machismo, and Marianismo
submitted by ssshet 35 minutes ago - Topic: Health
Hispanic women who are 50 years of age and older have been shown to be at increased risk of acquiring HIV infection due to age and culturally related issues. The purpose of our study was to investigate factors that increase HIV risk among older Hispanic women (OHW) as a basis for development or a...

HIV Risk Among Women From Domestic Violence Agencies: Prevalence and Correlates
submitted by ssshet 35 minutes ago - Topic: Health
The co-occurrence of HIV and intimate partner violence is a significant public health problem. Although these intersecting epidemics have been examined in various populations, limited data exist among recently abused women seeking services from domestic violence agencies. Our study examined sexua...




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