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Ferritins as nanoplatforms for imaging and drug delivery
submitted by kochrchi 19 minutes ago - Topic: Health
Due to unique architecture and surface properties, ferritin has emerged as an important class of biomaterial. Many studies suggest that ferritin and its derivatives hold great potential in a wide range of bio-applications. Areas covered: In this review, we summarize recent progress on employing ferritins as a platform to construct functional nanoparticles for applications in MRI, optical imagin...



Eating Quality Of Meat From Six Lamb Breed Types Raised In Brazil
submitted by 23456 23 minutes ago - Topic: Agriculture
Breed or genotype is important to consider for developing appropriate eating quality in lamb. The objectives of this study were to compare physical and chemical parameters and sensory acceptance of Longissimus lumborum (LL) muscle from six lamb breed types economically important to Brazilian sheep raising chain. No difference (P > 0.05) among samples was found in relation to L*, aand bparam...

HLA desensitization with bortezomib in a highly sensitized pediatric patient
submitted by ohjarth 24 minutes ago - Topic: Health
The proteasome inhibitor bortezomib has been used with variable success in the treatment of AMR following heart transplant. There is limited experience with this agent as a pretransplant desensitizing therapy. We report a case of successful HLA desensitization with a bortezomib-based protocol prior to successful heart transplantation. A nine-yr-old boy with dilated cardiomyopathy, not initially...

De novo amyloidosis in a renal transplant patient
submitted by ohjarth 24 minutes ago - Topic: Health
Systemic AA amyloidosis is a serious complication of many chronic inflammatory disorders and chronic infections. Renal involvement is seen in the majority of the patients and can lead to end-stage renal disease. Renal transplantation can be performed in these patients; however, amyloidosis can recur in the transplanted kidneys. On the other hand, de novo AA amyloidosis in renal transplant patie...

Assessment of the accuracy of (re)analyses in the equatorial lower stratosphere
submitted by phainex 26 minutes ago - Topic: Geography
The accuracy of horizontal winds and temperature in the equatorial lower stratosphere is evaluated in different (re)analyses (ECMWF operational analysis, ERA Interim and MERRA) using an independent dataset collected at low latitudes during long-duration balloon flights in early 2010. The 3 analyzed wind products are found significantly less accurate than in the extratropics, with periods of 10...



Electric field derivative waveforms from dart-stepped-leader steps in triggered lightning
submitted by phainex 26 minutes ago - Topic: Geography
Electric field derivative (dE/dt) pulse waveforms from dart-stepped leaders in rocket-and-wire triggered lightning, recorded a distance of 226 m from the channel base, are characterized. A single dE/dt pulse associated with a leader step consists of a fast initial rise of the same polarity as the following return stroke followed by an opposite polarity overshoot of smaller amplitude and subse...

Storm track activity over the North Pacific associated with the Madden-Julian Oscillation under ENSO conditions during boreal winter
submitted by phainex 26 minutes ago - Topic: Geography
The present study investigates modulation by the Madden-Julian Oscillation (MJO) of storm track activity (STA) over the North Pacific (NP) during boreal winter for El Ninõ and La Ninã periods. STA defined by vertically averaged synoptic eddy kinetic energy (EKE) greatly intensifies over the western North Pacific (WNP) and central-eastern North Pacific during La Ninã and El Ninõ years, respe...


A familial form of parkinsonism, dementia, and motor neuron disease: A longitudinal study
submitted by bolzonmv 30 minutes ago - Topic: Health
To describe the clinical, positron emission tomography (PET), pathological, and genetic findings of a large kindred with progressive neurodegenerative phenotypes in which the proband had autopsy-confirmed corticobasal degeneration (CBD). Five family members, including the proband, were examined neurologically. Clinical information from the other family members was collected by questionnaires. T...

Lifetime exposure to estrogens and Parkinson's disease in California teachers
submitted by bolzonmv 30 minutes ago - Topic: Health
Parkinson's disease (PD) is consistently observed to occur less frequently in women than men, prompting investigation into whether estrogen protects against neurodegeneration of dopaminergic neurons. We used baseline data in the California Teachers Study, a prospective cohort of women, to investigate whether reproductive factors indicating higher long-term estrogen levels are associated with PD...


Interactions between voluntary head control and neck proprioceptive reflexes in cervical dystonia
submitted by bolzonmv 30 minutes ago - Topic: Health
To investigate deficiencies in mechanisms of sensorimotor processing and reflexive–voluntary interactions leading to the impaired head position control in primary cervical dystonia. Thirteen patients and 23 healthy controls were subjected to transient, low amplitude, low velocity head-on-trunk, trunk-under-head and whole-body rotations in the horizontal plane. With the instruction not to resi...

Which features of Parkinson's disease predict earlier exit from the workforce?
submitted by bolzonmv 30 minutes ago - Topic: Health
Few objective data exist regarding predictors of leaving the workforce (LWF) in Parkinson's disease (PD). Employed PD patients were followed prospectively. Baseline demographics, disease duration, and measures of disease severity, cognition, disability, and mental health were compared between patients working at last follow-up versus those who left the workforce using student's t-tests and mult...


Drooling in Parkinson’s Disease: a review
submitted by bolzonmv 30 minutes ago - Topic: Health
Parkinson’s disease (PD) is a neurodegenerative disease causing both motor and non-motor symptoms. Drooling, an excessive pooling and spillover of saliva out of the oral cavity, is one of the non-motor symptoms in PD patients that produces various negative physical and psychosocial consequences for patients and their caregivers. At present, the pathophysiology of drooling in PD is not complet...

Calculating clinical progression rates in Parkinson’s disease: Methods matter
submitted by bolzonmv 30 minutes ago - Topic: Health
Disease progression in Parkinson’s disease is often calculated in data from cross-sectional studies, where a severity score (e.g. UPDRS-motor score) is divided by disease duration. While this intuitively may seem a plausible approach, it is uncertain if these rates are similar to those calculated from longitudinal data. The aim of this study is to examine if progression rates calculated accor...

Randomized, placebo-controlled trial of trimethobenzamide to control nausea and vomiting during initiation and continued treatment with subcutaneous apomorphine injection
submitted by bolzonmv 30 minutes ago - Topic: Health
Nausea and vomiting can occur in Parkinson’s disease (PD) patients initiated on apomorphine subcutaneous injections and antiemetic prophylaxis is recommended per product labeling. Data suggest long-term antiemetic prophylaxis may not be needed, although this has not been systematically studied. We evaluated coadministered trimethobenzamide with apomorphine in 182 PD subjects using a randomize...

Diagnostic accuracy of Parkinson’s disease and atypical parkinsonism in nursing homes
submitted by bolzonmv 30 minutes ago - Topic: Health
Management of Parkinson’s disease (PD) and atypical parkinsonism in nursing homes depends on a timely and accurate diagnosis. However, little is known about the diagnostic accuracy of these parkinsonian syndromes in nursing homes. We examined this issue in a large group of Dutch nursing home residents. Twelve large nursing home organisations in the Netherlands accounting for 100 nursing homes...