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Dedicated Bifurcation Paclitaxel-Eluting Stent BiOSS Expert® in the Treatment of Distal Left Main Stem Stenosis
submitted by 22 minutes ago - Topic: Health
The aim of this study was to assess prospectively the effectiveness and safety profile of distal left main stem (LMS) stenosis treatment with dedicated bifurcation paclitaxel-eluting stent BiOSS Expert®. Angioplasty of distal LMS stenosis is always a high-risk procedure, and optimal treatment is uncertain. This was a prospective international 2-center study, which enrolled patients with non-ST...



Impact on Prognosis of Periprocedural Bleeding after TAVI: Mid-Term Follow-Up of a Multicenter Prospective Study
submitted by 22 minutes ago - Topic: Health
Impact of periprocedural bleeding after transcatheter aortic valve implantation (TAVI) over mid-term prognosis remains still unclear. Consecutive patients who underwent TAVI from May 2008 to July 2012 were prospectively included and stratified according to life-threatening (LT) and major bleeding (MB). Mid-term all-cause death was the primary end-point, and 30-day death, vascular complications,...

Localized demodicosis due to Demodex cati on the muzzle of two cats treated with inhalant glucocorticoids
submitted by 22 minutes ago - Topic: Agriculture
Feline demodicosis due to Demodex cati is a rare skin disease often associated with concurrent disease and generalized immunosuppression. Local immunosuppression due to the application of topical immunomodulatory drugs, such as glucocorticoids and tacrolimus, or by tumour cells has been suggested as a potential trigger for development of localized demodicosis in humans and animals. The goal was...

Micoplasmi e ureaplasmi: aspetti clinici, stato attuale e prospettive delle tecniche diagnostiche
submitted by 22 minutes ago - Topic: Health
I micoplasmi isolati nell’uomo appartengono al genere Mycoplasma e Ureaplasma e si localizzano soprattutto a livello delle mucose dell’apparato respiratorio e genitourinario, come parassiti di superficie che aderiscono alla membrana plasmatica delle cellule epiteliali. Come patogeni della specie umana il loro comportamento è controverso: la maggior parte è commensale, altri veri patogeni ...

Attività piastrinica residua in pazienti in terapia con inibitori dei recettori P2Y12 e/o acido acetilsalicilico: 30 mesi di esperienza con il Multiplate®
submitted by 22 minutes ago - Topic: Health
Molti strumenti, basati su diverse tecnologie, sono in uso da alcuni anni per misurare la funzionalità piastrinica ex vivo. L’aggregometria a impedenza (multiple electrode aggregometry, MEA) è uno di questi sistemi di monitoraggio: l’aggregazione piastrinica nel sangue intero viene misurata dalle modifiche di impedenza elettrica causate dall’adesione delle piastrine, indotta da specific...



Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig
submitted by 24 minutes ago - Topic: Health
The microminipig, a small minipig was bred as a novel experimental animal for nonclinical pharmacology/toxicology studies by Fuji Micra Inc. (Shizuoka, Japan). Species differences in drug metabolism between humans and the microminipig need to be elucidated in more detail in order to discuss the results of nonclinical studies. Glucuronidation catalyzed by UDP-glucuronosyltransferase (UGT) is an ...

New perspective on characterizing pressure–sinkage relationship of terrains for estimating interaction mechanics
submitted by 25 minutes ago - Topic: Geography
Conventional pressure–sinkage models of characterizing bearing properties of terrains for vehicles are semi-empirical with poor adaptability and extrapolation ability; definitions of parameters are nonintuitive. The purpose of this paper is to provide more general and high-fidelity models for terrain characterization to satisfy the high requirements of autonomous wheeled vehicles, which shoul...


Assessing confined and semi-confined compression curves of highly calcareous remolded soil amended with farmyard manure
submitted by 25 minutes ago - Topic: Geography
Confined and semi-confined compression curves of a highly calcareous remolded soil amended with farmyard manure (FYM) from dairy cattle were investigated. The samples were collected from the topsoil of the experimental plots where FYM had been added to the soil at four application rates (0, 25, 50 and 100Mgha−1) for 7years. Large remolded specimens were prepared by applying 100kPa load at 17....

Application of an ANN-based methodology for road surface condition identification on mining vehicles and roads
submitted by 25 minutes ago - Topic: Geography
An artificial neural networks-based methodology for the identification of road surface condition was applied to two different vehicles in their normal operating environments at two mining sites. An ultra-heavy haul truck used for hauling operations in surface mining and a small utility underground mine vehicle were utilised in the current investigation. Unlike previous studies where numerical m...


Ride dynamics mathematical model for a single station representation of tracked vehicle
submitted by 25 minutes ago - Topic: Geography
Tracked vehicles are exposed to severe ride environment due to dynamic terrain-vehicle interactions. Hence it is essential to understand the vibration levels transmitted to the vehicle, as it negotiates different types of terrains at different speeds. The present study is focused on the development of single station representation of tracked vehicles with trailing arm hydro-gas suspension syste...

Effects of gravity on rigid rover wheel sinkage and motion resistance assessed using two-dimensional discrete element method
submitted by 25 minutes ago - Topic: Geography
Elucidating the effects of gravity on rover/rover wheel performance is important because it can provide a basis for predicting their performance on extraterrestrial surfaces based on test results obtained on Earth. of previous studies by Wong (2012) and by Wong and Kobayashi (2012) indicate that if in conducting performance testing of rovers/rover wheels on Earth with identical mass to that on ...


Navigating the city: gender and positionality in cultural geography research
submitted by 26 minutes ago - Topic: Geography
How is qualitative research in geography performed? What are some considerations relevant to qualitative research in the field? Answering these questions requires reflections on the role of positionality and gender in cultural geography research. This paper explores the various ways that insider/outsider status and gender impact urban fieldwork. In doing so, it demonstrates that the issues conf...

Serial brain 18FDG-PET in anti-AMPA receptor limbic encephalitis
submitted by 30 minutes ago - Topic: Health
Immunotherapy-responsive autoimmune CNS syndromes linked to antibodies targeting surface neuronal antigens lack reliable biomarkers of disease activity. We report serial cerebral 18FDG PET studies in a woman with AMPA receptor (AMPA-R) autoimmune limbic encephalitis. During her follow-up, despite an aggressive immunotherapy, she displayed a persistent, predominantly left hippocampal FDG hyperme...

Activation-induced cell death in T lymphocytes from multiple sclerosis patients
submitted by 30 minutes ago - Topic: Health
Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of activation induced cell-death (AICD) has been described in T lymphocytes from patients with multiple sclerosis (MS). The aim of this study was to evaluate AICD in T lymphocytes from patients with MS and healthy controls, and to explore the molecular mechanisms underlying the...

Levels of soluble TNF-RII are increased in serum of patients with primary progressive multiple sclerosis
submitted by 30 minutes ago - Topic: Health
The levels of soluble tumor necrosis factor receptor II (sTNF-RII) were determined in serum of 161 untreated multiple sclerosis (MS) patients with different clinical forms and 46 healthy controls (HC) by ELISA. Our results show that serum sTNF-RII levels were significantly increased in patients with primary progressive MS (PPMS) compared with other MS forms and HC. Although sTNF-RII levels sign...

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