Biology Agriculture Aquaculture Horticulture Postharvest Forestry Geography Environment Health





View All

A short-term laboratory and in situ sediment assay based on the postexposure feeding of the estuarine isopod Cyathura carinata
submitted by ijo 20 minutes ago - Topic: Environment
In situ assays based on feeding depression have been proposed as sublethal assays able to assess immediate contaminant effects on key ecosystem functions, long before effects on life-history traits can be detected. The in situ peculiarities provide more realistic exposure scenarios than laboratory-controlled conditions, which is particularly relevant for estuarine ecosystems where environmental...



A systematic study of the disposition and metabolism of mercury species in mice after exposure to low levels of thimerosal (ethylmercury)
submitted by ijo 20 minutes ago - Topic: Environment
Thimerosal (TM) is an ethylmercury (etHg)-containing preservative used in some vaccines despite very limited knowledge on the kinetics and direct interaction/effects in mammals׳ tissues after exposure. Thus, this study aimed to evaluate the kinetics of Hg species in mice in a time course analysis after intramuscular injection of TM, by estimating Hg half-lives in blood and tissues. Mice were e...

Persistent organic pollutants and liver dysfunction biomarkers in a population-based human sample of men and women
submitted by ijo 22 minutes ago - Topic: Environment
Persistent organic pollutants (POPs) are stable organic compounds generated through different industrial activities. Liver is involved in the metabolism of POPs, and hence exposure to POPs may interfere with liver function. Although a few studies have shown adverse effects of POPs on liver function, large-scale studies involving humans are lacking. We performed this large population-based cross...

Low-level mercury in children: Associations with sleep duration and cytokines TNF-α and IL-6
submitted by ijo 22 minutes ago - Topic: Environment
There is a sizeable literature suggesting that mercury (Hg) exposure affects cytokine levels in humans. In addition to their signaling role in the immune system, some cytokines are also integrally associated with sleep behavior. In this cross-sectional study of 9–11 year old children (N=100), we measured total blood Hg in whole blood, serum levels of tumor necrosis factor α (TNF-α) and inte...

Exposure to elevated temperatures and risk of preterm birth in Valencia, Spain
submitted by ijo 22 minutes ago - Topic: Environment
Prematurity is the second-leading cause of death in children under the age of 5 worldwide. It is predicted that the future climate will have more intense, longer lasting and frequent extreme heat episodes, and so the temperature effect on the risk of preterm birth is generating considerable interest in the public health field. Our aim was to explore the potential short-term effects of elevated ...



Organochlorine chemicals and neurodegeneration among elderly subjects in Costa Rica
submitted by ijo 22 minutes ago - Topic: Environment
We previously screened 400 elderly Costa Ricans for neurodegenerative disease. Those reporting occupational pesticide exposure (18%) had an increased Parkinson׳s disease (PD) risk (OR 2.57, 95% CI 0.91–7.26), and worse cognition (Mini-Mental States Exam (MMSE) 24.5 versus 25.9 points, p=0.01). We subsequently measured long-lasting organochlorine pesticides (β-HCH, DDE, DDT, and dieldrin) in...

The effects of air pollution on adverse birth outcomes
submitted by ijo 22 minutes ago - Topic: Environment
Air pollution has been shown to have adverse effects on many health outcomes including cardiorespiratory diseases and cancer. However, evidence on the effects of prenatal exposure is still limited. The purpose of this retrospective cohort study is to evaluate the effects of prenatal exposure to air pollutants including particulate matter with aerodynamic diameter less than 2.5μm (PM2.5) and oz...


Persistent organic pollutants are related to the change in circulating lipid levels during a 5 year follow-up
submitted by ijo 22 minutes ago - Topic: Environment
When reporting circulating levels of persistent organic pollutants (POPs), usually lipid-normalized values are given. However, animal experiments and some human data indicate that exposure to POPs may change lipid values. The aim of the present study is to investigate if POP levels can predict future changes in levels of circulating lipids. In the population-based Prospective Investigation of t...

Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma
submitted by iic 31 minutes ago - Topic: Health
Endometrial adenocarcinoma is one of the most common gynecologic malignancies worldwide and in stages confined to the uterus considered to have an excellent prognosis. However, in advanced or recurrent cases when surgery fails to achieve disease control other treatment options are less effective. Thus, new therapeutic avenues are needed. To provide the rationale for the use of novel agents that...


Improved survival of patients with cervical cancer treated with image-guided brachytherapy compared with conventional brachytherapy
submitted by iic 31 minutes ago - Topic: Health
Since the Group Européen de Curiethérapie and the European Society for Radiotherapy and Oncology (GEC–ESTRO) published recommendations for 3D MRI-based image-guided adaptive brachytherapy (IGBT) in the treatment of cervical cancer, many institutions have implemented this technique and favourable results were documented. We investigated if introduction of IGBT in our centre indeed improved t...

Phase II Study of oral ridaforolimus in Women With Recurrent or Metastatic Endometrial Cancer
submitted by iic 31 minutes ago - Topic: Health
The phosphatidylinositol-3 kinase/serine-threonine kinase PI3K/AKT pathway is postulated to be central to cancer cell development. Activation of this pathway is believed to promote angiogenesis, protein translation and cell cycle progression. A large percentage of endometrial carcinomas have demonstrated mutations within this regulation pathway which result in constitutional activation. The dow...


Accuracy of robotic sentinel lymph node detection (RSLND) for patients with endometrial cancer (EC)
submitted by iic 31 minutes ago - Topic: Health
Lymphadenectomy as a part of the staging for EC patients is controversial. Sentinel lymph node detection has been introduced to determine which patients would benefit from adjuvant therapy and to limit morbidities associated with a full pelvic nodal dissection. The purpose of this study is to evaluate diagnostic accuracy and detection rate of robotic sentinel lymph node detection (RSLND) as par...

The effect of neighborhood-level socioeconomic status on racial differences in ovarian cancer treatment in a population-based analysis in Chicago
submitted by iic 31 minutes ago - Topic: Health
Less than half of women with ovarian cancer and blacks specifically receive therapy adherent to National Comprehensive Cancer Network (NCCN) guidelines. The purpose is to assess the effect of neighborhood-level socioeconomic status (SES) on black-white treatment differences in a population-based analysis in a highly-segregated community. Illinois State Cancer Registry data for invasive epitheli...

Transformation of the education of health professionals in China: progress and challenges
submitted by sasonstontan 32 minutes ago - Topic: Health
In this Review we examine the progress and challenges of China's ambitious 1998 reform of the world's largest health professional educational system. The reforms merged training institutions into universities and greatly expanded enrolment of health professionals. Positive achievements include an increase in the number of graduates to address human resources shortages, acceleration of productio...

Harnessing the privatisation of China's fragmented health-care delivery
submitted by sasonstontan 32 minutes ago - Topic: Health
Although China's 2009 health-care reform has made impressive progress in expansion of insurance coverage, much work remains to improve its wasteful health-care delivery. Particularly, the Chinese health-care system faces substantial challenges in its transformation from a profit-driven public hospital-centred system to an integrated primary care-based delivery system that is cost effective and ...