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Demographic clinical and prognostic characteristics of primary ovarian, peritoneal and tubal adenocarcinomas of serous histology — A prospective comparative study
submitted by iic 14 minutes ago - Topic: Health
Invasive serous adenocarcinomas may present as primary ovarian (POC), primary fallopian tube (PFC) or primary peritoneal (PPC) carcinomas. Whether they are variants of the same malignancy or develop through different pathways is debated. Population-based prospectively collected data on POC (n=1443), PPC (n=268) and PFC (n=171) cases was obtained from the Danish Gynecological Cancer Database (20...



Taselisib, a selective inhibitor of PIK3CA, is highly effective on PIK3CA-mutated and HER2/neu amplified uterine serous carcinoma in vitro and in vivo
submitted by iic 14 minutes ago - Topic: Health
To evaluate the efficacy of Taselisib, a selective inhibitor of PIK3CA, against primary uterine serous carcinomas (USC) harboring PIK3CA mutations and HER2/neu gene amplification. Sensitivity to taselisib was evaluated by flow-cytometry viability assays in vitro against nine primary USC cell lines. Cell cycle distribution and downstream signaling were assessed by measuring the DNA content of ce...

Early integration of palliative care facilitates the discontinuation of anticancer treatment in women with advanced breast or gynecologic cancer
submitted by iic 14 minutes ago - Topic: Health
To evaluate some health indicators in women with advanced breast or gynecological cancer (ABGC) after discontinuation of active cancer treatment in function of the model of care received. This prospective study included patients who were discontinuing anticancer treatment to be followed up only with Palliative Care (PC). Patients who had been evaluated at least once in PC were categorized into ...

Inhibition of epithelial ovarian cancer by Minnelide, a water-soluble pro-drug
submitted by iic 14 minutes ago - Topic: Health
Minnelide is a water-soluble pro-drug of triptolide, a natural product. The goal of this study was to evaluate the effectiveness of Minnelide on ovarian cancer growth in vitro and in vivo. The effect of Minnelide on ovarian cancer cell proliferation was determined by real time electrical impedance measurements. Multiple mouse models with C200 and A2780 epithelial ovarian cancer cell lines were ...

Integrated collaborative care for comorbid major depression in patients with cancer (SMaRT Oncology-2): a multicentre randomised controlled effectiveness trial
submitted by sasonstontan 14 minutes ago - Topic: Health
Medical conditions are often complicated by major depression, with consequent additional impairment of quality of life. We aimed to compare the effectiveness of an integrated treatment programme for major depression in patients with cancer (depression care for people with cancer) with usual care. SMaRT Oncology-2 is a parallel-group, multicentre, randomised controlled effectiveness trial. We en...



Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial
submitted by sasonstontan 14 minutes ago - Topic: Health
Impetigo affects more than 110 million children worldwide at any one time. The major burden of disease is in developing and tropical settings where topical antibiotics are impractical and lead to rapid emergence of antimicrobial resistance. Few trials of systemic antibiotics are available to guide management of extensive impetigo. As such, we aimed to compare short-course oral co-trimoxazole wi...

Effects of Acupressure on Menstrual Distress and Low Back Pain in Dysmenorrheic Young Adult Women: An Experimental Study
submitted by bioagri 18 minutes ago - Topic: Health
The purpose of this study was to examine the effects of acupressure on menstrual distress and low back pain (LBP) in dysmenorrheic young adult women. In all, 129 female students, who had been experiencing dysmenorrhea with LBP during menstruation and who scored more than 4 points on the visual analog scale for pain, were randomly assigned to an experimental group and a control group. The experi...


Progression of Pain in Ambulatory HIV-positive South Africans
submitted by bioagri 18 minutes ago - Topic: Health
Cross-sectional studies report that pain in ambulatory HIV-infected individuals is frequent and often undermanaged. Expanding access to HIV treatment in developing countries means that infected individuals are living longer, but there is a dearth of pain-directed studies from developing countries that describe the progression of pain and its treatment over any period of time. The aim of this st...

Sickle Cell Disease Pain Management in Adolescents: A Literature Review
submitted by bioagri 18 minutes ago - Topic: Health
Sickle cell disease (SCD) pain continues to emerge in adolescents. More than 98,000 individuals are believed to have SCD in the United States. In fact, 1 in 500 Black infants will be affected by SCD. Identifying standards of care for this unique population can improve pain management and treatment. A significant effect of vaso-occlusive crisis is a decrease in the quality of life in children. T...


Exploring Diversity among Norwegian Borrelia Strains Originating from Ixodes ricinus Ticks
submitted by irecoggriy 18 minutes ago - Topic: Biology
Characterisation of Borrelia strains from Ixodes ricinus ticks is important in the epidemiological surveillance of vector-borne pathogens. Multilocus sequences analysis (MLSA) is a molecular genotyping tool with high discriminatory power that has been applied in evolutionary studies and for the characterisation of Borrelia genospecies. MLSA was used to study genetic variations in Borrelia strai...

From membrane excitability to metazoan psychology
submitted by tozzaka 19 minutes ago - Topic: Health
Unlike the nonexcitable cell membranes that are ubiquitous in all domains of life, excitable membranes are found almost exclusively in animal organisms (Protozoa and Metazoa). Their transient permeability to ion flow makes possible the rapid detection of, and response to, external stimuli, and results in the phenomena that most clearly distinguish fauna from flora: perception, cognition, and mo...


Stereotactive Ablative Radiotherapy (SABR) in inoperable oligometastatic disease from colorectal cancer: a safe and effective approach
submitted by tammol32 19 minutes ago - Topic: Health
To assess the safety and efficacy of Stereotactic Ablative Radiotherapy (SABR) in oligometastatic patients from colorectal cancer. 82 patients with 1-3 inoperable metastases confined to one organ (liver or lung), were treated with SABR for a total of 112 lesions in an observational study. Prescription dose ranged between 48 and 75Gy in 3 or 4 consecutive fractions. Primary end-points were local...

A computational model to predict bone metastasis in breast cancer by integrating the dysregulated pathways
submitted by tammol32 19 minutes ago - Topic: Health
Although there are a lot of researches focusing on cancer prognosis or prediction of cancer metastases, it is still a big challenge to predict the risks of cancer metastasizing to a specific organ such as bone. In fact, little work has been published for such a purpose nowadays. In this work, we propose a Dysregulated Pathway Based prediction Model (DPBM) built on a merged data set with 855 sam...

Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer
submitted by tammol32 19 minutes ago - Topic: Health
Ovarian tumors create a dynamic microenvironment that promotes angiogenesis and reduces immune responses. Our research has revealed that threonyl-tRNA synthetase (TARS) has an extracellular angiogenic activity separate from its function in protein synthesis. The objective of this study was to test the hypothesis that TARS expression in clinical samples correlates with angiogenic markers and ova...

Evaluation of the walk-through inflatable colon as a colorectal cancer education tool: results from a pre and post research design
submitted by tammol32 19 minutes ago - Topic: Health
Colorectal cancer (CRC) is a disease that can be prevented through early detection. Through the use of effective educational tools, individuals can become better informed about CRC and understand the importance of screening and early detection. The walk through Inflatable Colon is an innovative educational resource developed to engage and educate communities on CRC and the importance of receivi...