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Comparisons between two biochemical markers in evaluating periodontal disease severity: a cross-sectional study
submitted by chaanshiin 17 minutes ago - Topic: Health
The purpose of this study was to compare two biochemical markers, which have been previously used to determine the degrees of alveolar bone destruction, in evaluating periodontal disease severity. The WF6 epitope of chondroitin sulfate (CS) and the alkaline phosphatase (ALP) levels were determined in gingival crevicular fluid (GCF) samples collected from patients with various degrees of disease...



Agent-based model of fecal microbial transplant effect on bile acid metabolism on suppressing Clostridium difficile infection: an example of agent-based modeling of intestinal bacterial infection
submitted by harn 18 minutes ago - Topic: Health
Agent-based modeling is a computational modeling method that represents system-level behavior as arising from multiple interactions between the multiple components that make up a system. Biological systems are thus readily described using agent-based models (ABMs), as multi-cellular organisms can be viewed as populations of interacting cells, and microbial systems manifest as colonies of indivi...

The bifactor structure and the “dark nomological network” of the State Self-Esteem Scale
submitted by dacrhio13 20 minutes ago - Topic: Health
The State Self-Esteem Scale (SSES) measures transient feelings of self-worth. The SSES has been hypothesized to possess a number of latent structures, ranging from one to three factors. The present study compared these putative structures along with a newly hypothesized bifactor structure (i.e., one global factor, three subfactors). offered greatest support for the bifactor model. A secondary g...

The Aeronomy of Mars: Characterization by MAVEN of the Upper Atmosphere Reservoir That Regulates Volatile Escape
submitted by xchenanex 20 minutes ago - Topic: Geography
The Mars thermosphere-ionosphere-exosphere (TIE) system constitutes the atmospheric reservoir (i.e. available cold and hot planetary neutral and thermal ion species) that regulates present day escape processes from the planet. The characterization of this TIE system, including its spatial and temporal (e.g., solar cycle, seasonal, diurnal, episodic) variability is needed to determine present da...

Examining the relationship between face processing and social interaction behavior in children with and without autism spectrum disorder
submitted by girordamx 20 minutes ago - Topic: Health
Children with autism spectrum disorder (ASD) show impairment in reciprocal social communication, which includes deficits in social cognition and behavior. Since social cognition and social behavior are considered to be interdependent, it is valuable to examine social processes on multiple levels of analysis. Neuropsychological measures of face processing often reveal deficits in social cognitio...



Typical and Atypical Development of Visual Attention in 3- to 9-Month-Old Infants
submitted by crazmeis 20 minutes ago - Topic: Health
The interactions between attention and stimulus encoding in infancy were examined using heart rate (HR) and visual habituation measures. At 3, 6, and 9 months of age, infants (N = 119) were habituated to an adult face; longest look (LL) duration was measured as an indicator of encoding speed. Three groups were formed based on LL change from 3 to 9 months: Large Decrease, Small Decrease, and...

Pointing as Epistemic Request: 12-month-olds Point to Receive New Information
submitted by crazmeis 20 minutes ago - Topic: Health
Infants start pointing systematically to objects or events around their first birthday. It has been proposed that infants point to an event to share their appreciation of it with others. In this study, we tested another hypothesis, according to which infants’ pointing could also serve as an epistemic request directed to the adult. Thus, infants’ motivation for pointing could include the exp...


Survival and early recourse to care for dementia: A population based study
submitted by fvw64 21 minutes ago - Topic: Health
A large proportion of dementia cases are still undiagnosed. although early dementia care has been hypothesized to benefit both patients and families, evidence-based benefits are lacking. Thus, investigating the benefits for newly demented persons according to their recourse to care in the “real life” appears critical. We examined the relation between initial care recourse care and demented ...

Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance
submitted by fvw64 21 minutes ago - Topic: Health
This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation. The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to al...


Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study
submitted by fvw64 21 minutes ago - Topic: Health
Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD. Blood exosomes obtained at one time-point from patients with AD (n = 57) or frontotemporal dementia (FTD) (n = 16), and at two time-points from others (n = 24) when cognitively normal and 1 to 10 years later when diagnosed...

Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline
submitted by fvw64 21 minutes ago - Topic: Health
Longitudinal data on the role of atherosclerosis in different vessel beds in the etiology of cognitive impairment and dementia are scarce and inconsistent. Between 2003–2006, 2364 nondemented persons underwent computed tomography of the coronaries, aortic arch, extracranial, and intracranial carotid arteries to quantify atherosclerotic calcification. Participants were followed for incident de...


The Israel Diabetes and Cognitive Decline (IDCD) study: Design and baseline characteristics
submitted by fvw64 21 minutes ago - Topic: Health
Type 2 diabetes (T2D) is associated with increased risk of dementia. The prospective longitudinal Israel Diabetes and Cognitive Decline study aims at identifying T2D-related characteristics associated with cognitive decline. Subjects are population-based T2D 65+, initially cognitively intact. Medical conditions, blood examinations, and medication use data are since 1998; cognitive, functional, ...

Temporal evolution of biomarkers and cognitive markers in the asymptomatic, MCI, and dementia stage of Alzheimer's disease
submitted by fvw64 21 minutes ago - Topic: Health
We investigated the pattern of disease progression in the asymptomatic, mild cognitive impairment (MCI), and dementia stage of Alzheimer's disease (AD). We selected 284 subjects with AD pathology, defined as abnormal levels of amyloid beta 1–42 (Aβ1–42) in cerebrospinal fluid (CSF). Disease outcome measures included six biomarkers and five cognitive markers. We compared differences in base...

A structure-based approach to predict predisposition to amyloidosis
submitted by fvw64 21 minutes ago - Topic: Health
Neurodegenerative diseases and other amyloidoses are linked to the formation of amyloid fibrils. It has been shown that the ability to form these fibrils is coded by the amino acid sequence. Existing methods for the prediction of amyloidogenicity generate an unsatisfactory high number of false positives when tested against sequences of the disease-related proteins. Recently, it has been shown t...

Prevalence of dementia in the oldest old: The Monzino 80-plus population based study
submitted by fvw64 21 minutes ago - Topic: Health
Epidemiological studies commonly include too few of the oldest old to provide accurate prevalence rates of dementia in older age groups. Estimates of the number of those affected, necessary for healthcare planning, are thus flawed. The objective is to estimate the prevalence of dementia and levels of dementia severity in a very large population of oldest old and to investigate the relation betw...