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How often do condoms fail? A cross-sectional study exploring incomplete use of condoms, condom failures and other condom problems among black and white MSM in southern USA
submitted by miow 17 minutes ago - Topic: Health
To compare the occurrence of risk-inducing condom events (condom failures and incomplete use) and the frequency of their antecedents (condom errors, fit/feel problems and erection problems) between black and white men who have sex with men (MSM), and determine the associations between risk-inducing condom events and their antecedents. We studied cross-sectional data of 475 MSM who indicated usi...



Effects of Baclofen and Naltrexone, Alone and in Combination, on the Consumption of Palatable Food in Male Rats
submitted by silsay74 18 minutes ago - Topic: Health
Excess consumption of palatable food has been shown to affect reward-related brain regions, and pharmaceutical treatments for drug addiction may also be effective in treating overeating of such foods. The GABA-B agonist baclofen and opioid antagonist naltrexone have both been used to treat addiction, and have been shown to suppress intake of certain foods. The combination of these drugs has sho...

A New Look at Risk-Taking: Using a Translational Approach to Examine Risk-Taking Behavior on the Balloon Analogue Risk Task
submitted by silsay74 18 minutes ago - Topic: Health
Models of risk-taking typically assume that the variability of outcomes is important in the likelihood of making a risky choice. In an animal model of the Balloon Analogue Risk Task (BART), within-session variability, or the coefficient of variability (CV), was found to be a novel predictor of behavior (Jentsch et al., 2010). Human studies have not investigated how BART performance differs when...

A Naturalistic Comparison of the Effectiveness of Methadone and Two Sublingual Formulations of Buprenorphine on Maintenance Treatment Outcomes: Findings From a Retrospective Multisite Study
submitted by silsay74 18 minutes ago - Topic: Health
This study sought to compare the effectiveness of the 3 most commonly prescribed maintenance medications in the United States indicated for the treatment of opioid dependence in reducing illicit drug use and retaining patients in treatment. Data were abstracted from electronic medical records for 3,233 patients admitted to 34 maintenance treatment facilities located throughout the United States...

Effects of density and sowing pattern on weed suppression and grain yield in three varieties of maize under high weed pressure
submitted by tamradd 24 minutes ago - Topic: Agriculture
We tested the hypothesis that improved weed suppression by maize can be achieved through increased crop density and spatial uniformity. Field experiments on three varieties of maize sown at three densities (5, 7 and 10.5 seeds m−2) and in two spatial patterns (grid pattern and rows) under very high weed pressure from Brachiaria brizantha were performed in 2012 and 2013. We measured weed bio...



Deconstructing ecosystem services: Uncertainties and controversies around a socially constructed concept
submitted by tormik97 28 minutes ago - Topic: Geography
Because of its success, the concept of ecosystem services (ES) is increasingly taken for granted, without sufficient questioning of the strong uncertainties and controversies that surround it. In this paper, we consider this concept as socially constructed and we analyze the surrounding controversies in order to decipher the process through which it is constructed. From a literature review, we ...

Migration, vulnerability and the complexity of violence: Experiences of documented non-EU migrants in Slovakia
submitted by tormik97 28 minutes ago - Topic: Geography
Migration to East and Central Europe (ECE) remains under-researched, not least because of the relatively small number of migrants in the region. Exploring experiences of documented non-EU migrants in Slovakia with various forms of violence – including violence motivated by hate and associated with work exploitation – the paper uncovers patterns of violence and vulnerability across the migra...


Eroding battlefields: Land degradation in Java reconsidered
submitted by tormik97 28 minutes ago - Topic: Geography
Land degradation has been a major political issue in Java for decades. Its causes have generally been framed by narratives focussing on farmers’ unsustainable cultivation practices. This paper causally links land degradation with struggles over natural resources in Central Java. It presents a case study that was part of a research project combining remote sensing and political ecology to expl...

Effets pléïotropes du sévélamer, précurseur d’agent chélateur de la voie intestinale
submitted by jovidhart 53 minutes ago - Topic: Health
Le nombre de patients souffrant d’une maladie rénale chronique (MRC), avec ses pathologies associées, a augmenté de façon majeure dans le monde entier au cours des dernières années. Aussi, de nombreuses études expérimentales et cliniques ont examiné, au cours de la dernière décennie, les mécanismes impliqués, en particulier pour expliquer la forte augmentation de mortalité cardi...


Uremic toxicity and sclerostin in chronic kidney disease patients
submitted by jovidhart 53 minutes ago - Topic: Health
Sclerostin is a circulating inhibitor of the Wnt/β-catenin pathway and may have a role in chronic kidney disease (CKD)-mineral and bone disorder. Blood sclerostin levels are known to be elevated in patients undergoing maintenance dialysis. The aims of the present study were to evaluate sclerostin levels in patients at different CKD stages and study potential associations between sclerostin lev...

Building sense out of situational complexity: The role of ambivalence in creating functional leadership processes
submitted by bollyeon 54 minutes ago - Topic: Health
There is growing consensus among scholars that the organizational environment has become increasingly complex, dynamic, and socially demanding. Leaders and followers navigate through a cognitive paradox where assessments of the situation can be at once cognitively overpowering and cognitively deceiving. In this article, we propose that complex situations can lead to ambivalence, a psychological...


On the role of experience in ethical decision making at work: An ethical expertise perspective
submitted by bollyeon 54 minutes ago - Topic: Health
Previous research has produced contradictory results on whether and how "experience" relates to ethical decision making in the workplace. Maintaining that these divergent findings result from underspecified and inconsistent treatments of experience in the business ethics literature, we build theory around experience and its connection to ethical decision making. To this end, we draw upon and ad...

Exchange and Complementation of Genes Coding for Photosynthetic Reaction Center Core Subunits among Purple Bacteria
submitted by mnasawetz 1 hour ago - Topic: Biology
A mutant of the phototrophic species belonging to the β-proteobacteria, Rubrivivax gelatinosus, lacking the photosynthetic growth ability was constructed by the removal of genes coding for the L, M, and cytochrome subunits of the photosynthetic reaction center complex. The L, M, and cytochrome genes derived from five other species of proteobacteria, Acidiphilium rubrum, Allochromatium vinosum,...

From conventional chemotherapy to targeted therapy: use of monoclonal antibodies (moAbs) in gastrointestinal (GI) tumors
submitted by corlahomilenck 1 hour ago - Topic: Health
In recent years, significant progress has been made in the diagnosis and treatment of gastrointestinal cancers. Researches and clinicians however are still faced with challenges, not the least is the detection and management of tumors with varied gene mutation status. Clarification of the molecular pathology of gastrointestinal cancers may improve treatment options as well as quality of life an...

A novel FGF2 antagonist peptide P8 with potent antiproliferation activity
submitted by corlahomilenck 1 hour ago - Topic: Health
Some fibroblast growth factors (FGFs) play a critical role in tumorigenesis and progression. Among them, FGF2 was highly expressed in some tumors, and antagonists binding to FGF2 can suppress the growth of tumor cells. Therefore, FGF2 has been considered as an important target in cancer therapy. In this study, we identified a novel FGF2-binding short peptide (P8, PLLQATAGGGS-NH2) using phage di...