Biology Agriculture Aquaculture Horticulture Postharvest Forestry Geography Environment Health





View All

Perceived trustworthiness of faces drives trust behaviour in children
submitted by niaraindacreni 46 minutes ago - Topic: Health
Facial appearances can powerfully influence adults' trust behaviour, despite limited evidence that these cues constitute honest signals of trustworthiness. It is not clear, however, whether the same is also true for children. The current study investigated whether, like adults, 5-year-olds and 10-year-olds are more likely to place their trust in partners that look trustworthy than those that lo...



Children use salience to solve coordination problems
submitted by niaraindacreni 46 minutes ago - Topic: Health
Humans are routinely required to coordinate with others. When communication is not possible, adults often achieve this by using salient cues in the environment (e.g. going to the Eiffel Tower, as an obvious meeting point). To explore the development of this capacity, we presented dyads of 3-, 5-, and 8-year-olds (N = 144) with a coordination problem: Two balls had to be inserted into the same...

Institutional care and iron deficiency increase ADHD symptomology and lower IQ 2.5–5 years post-adoption
submitted by niaraindacreni 47 minutes ago - Topic: Health
Increased ADHD symptomology and lower IQ have been reported in internationally adopted (IA) children compared to non-adopted peers (Hostinar, Stellern, Schaefer, Carlson & Gunnar, ; Kreppner, O'Connor & Rutter, ). However, it is unclear whether these outcomes are due to institutional deprivation specifically or to co-occurring micronutrient deficiencies that disrupt brain development (Fuglestad...

Cancer stem cells, cancer cell plasticity and radiation therapy
submitted by bole 49 minutes ago - Topic: Health
Since the first prospective identification of cancer stem cells in solid cancers the cancer stem cell hypothesis has reemerged as a research topic of increasing interest. It postulates that solid cancers are organized hierarchically with a small number of cancer stem cells driving tumor growth, repopulation after injury and metastasis. They give rise to differentiated progeny, which lack these ...

Understanding & exploiting 5T4 oncofoetal glycoprotein expression
submitted by bole 49 minutes ago - Topic: Health
Oncofoetal antigens are present during foetal development with generally limited expression in the adult but are upregulated in cancer. These molecules can sometimes be used to diagnose or follow treatment of tumours or as a target for different immunotherapies. The 5T4 oncofoetal glycoprotein was identified by searching for shared surface molecules of human trophoblast and cancer cells with th...



Evolving paradigms in multifocal breast cancer
submitted by bole 49 minutes ago - Topic: Health
The 7th edition of the TNM defines multifocal breast cancer as multiple simultaneous ipsilateral and synchronous breast cancer lesions, provided they are macroscopically distinct and measurable using current traditional pathological and clinical tools. According to the College of American Pathologists (CAP), the characterization of only the largest lesion is considered sufficient, unless the gr...

An oncofetal and developmental perspective on testicular germ cell cancer
submitted by bole 49 minutes ago - Topic: Health
Germ cell tumors (GCTs) represent a diverse group of tumors presumably originating from (early fetal) developing germ cells. Most frequent are the testicular germ cell cancers (TGCC). Overall, TGCC is the most frequent malignancy in Caucasian males (20-40yr) and remains an important cause of (treatment related) mortality in these young men. The strong association between the phenotype of TGCC s...


The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer
submitted by bole 49 minutes ago - Topic: Health
The post-transcriptional control of gene expression mediated by RNA-binding proteins (RBPs), long non-coding RNAs (lncRNAs) as well as miRNAs is essential to determine tumor cell fate and thus is a major determinant in cancerogenesis. The IGF2 mRNA binding protein family (IGF2BPs) comprises three RBPs. Two members of the family, IGF2BP1 and IGF2BP3, are bona fide oncofetal proteins, which are d...

The receptor tyrosine kinase ROR1 an oncofetal antigen for targeted cancer therapy
submitted by bole 49 minutes ago - Topic: Health
Targeted cancer therapies have emerged as new treatment options for various cancer types. Among targets, receptor tyrosine kinases (RTKs) are among the most promising. ROR1 is a transmembrane RTK of importance during the normal embryogenesis for the central nervous system, heart, lung and skeletal systems, but is not expressed in normal adult tissues. However, ROR1 is overexpressed in several h...


FOXM1: A key oncofoetal transcription factor in health and disease
submitted by bole 49 minutes ago - Topic: Health
Forkhead Box M1 (FOXM1) is a bona fide oncofoetal transcription factor, which orchestrates complex temporal and spatial gene expression throughout embryonic and foetal development as well as during adult tissue homeostasis and repair. Controlled FOXM1 expression and activity provides a balanced transcriptional programme to ensure proper growth and maturation during embryogenesis and foetal deve...

Nodal signaling promotes a tumorigenic phenotype in human breast cancer
submitted by bole 50 minutes ago - Topic: Health
The Ras-ERK pathway is deregulated in approximately a third of human cancers, particularly those of epithelial origin. In aggressive, triple-negative, basal-like breast cancers, most tumors display increased MEK and ERK phosphorylation and exhibit a gene expression profile characteristic of Kras or EGFR mutant tumors; however, Ras family genetic mutations are uncommon in triple-negative breast ...


Treatment of an ECF bleaching effluent with white-rot fungi in an air-lift bioreactor
submitted by lene253541 56 minutes ago - Topic: Environment
Pulp and paper mills utilise huge amount of natural resources, inorganic and organic materials along with large volume of water in different stages of paper manufacturing, resulting in a significant volume of effluents. The aim of this work was to investigate the treatment of a bleaching effluent [effluent chlorine free (ECF)] from the cellulose industry with white-rot fungi in an air-lift bior...

Curcumin inhibits the replication of enterovirus 71 in vitro
submitted by j5onjin 1 hour ago - Topic: Health
Human enterovirus 71 (EV71) is the main causative pathogen of hand, foot, and mouth disease (HFMD) in children. The epidemic of HFMD has been a public health problem in Asia-Pacific region for decades, and no vaccine and effective antiviral medicine are available. Curcumin has been used as a traditional medicine for centuries to treat a diversity of disorders including viral infections. In this...

Complications of tibio-talar-calcaneal fusion using intramedullary nails
submitted by apsengh 1 hour ago - Topic: Health
Hindfoot nails are being increasingly used, however significant complications can occur. The purpose of this study was to assess the complications following the use of hindfoot nails at our institution. We identified patients from a retrospective database. All underwent hindfoot nailing under the care of the senior author. Details of complications were recorded. We identified 52 patients underg...

Results after gastrocnemius recession in 73 patients
submitted by apsengh 1 hour ago - Topic: Health
Very few studies describe the clinical results and complications following the surgical procedure of gastrocnemius recession. To survey the patient reported outcomes in patients operated with gastrocnemius recession as single procedure for various foot conditions. 93 patients operated with gastrocnemius recession as single procedure between 2006 and 2011 were detected in the database. 73 patien...