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Network meta-analysis of multiple outcome measures accounting for borrowing of information across outcomes
submitted by dlianawins 17 minutes ago - Topic: Health
Network meta-analysis (NMA) enables simultaneous comparison of multiple treatments while preserving randomisation. When summarising evidence to inform an economic evaluation, it is important that the analysis accurately reflects the dependency structure within the data, as correlations between outcomes may have implication for estimating the net benefit associated with treatment. A multivariate...



Dicrocoelium chinensis and Dicrocoelium dendriticum (Trematoda: Digenea) are distinct lancet fluke species based on mitochondrial and nuclear ribosomal DNA sequences
submitted by brejsdi 18 minutes ago - Topic: Biology
Lancet flukes parasitize the bile ducts and gall bladder of a range of mammals, including humans, causing dicrocoeliosis. In the present study, we sequenced and characterized the complete mitochondrial (mt) genomes as well as the first and second internal transcribed spacers (ITS-1 and ITS-2=ITS) of nuclear ribosomal DNA (rDNA) of two lancet flukes, Dicrocoelium chinensis and D. dendriticum. Se...

Mitogenomic data resolve basal relationships among passeriform and passeridan birds
submitted by brejsdi 18 minutes ago - Topic: Biology
Passerine birds compose over half of avian species diversity and exhibit an impressive array of phenotypic variation of interest to evolutionary biologists. Although this group has long been the focus of comparative study, many phylogenetic relationships within the group remain unresolved, despite an impressive number of molecular phylogenetic studies. Much of this uncertainty involves “trans...

Towards a phylogeny of the Tenebrionoidea (Coleoptera)
submitted by brejsdi 18 minutes ago - Topic: Biology
The phylogenetic relationships of the beetle superfamily Tenebrionoidea are investigated using the most comprehensive genetic data set compiled to date. With ∼34,000 described species in approximately 1250 genera and 28 families, Tenebrionoidea represent one of the most diverse and species-rich superfamilies of beetles. The interfamilial relationships of the Tenebrionoidea are poorly known; p...

The evolutionary jigsaw puzzle of the surviving trout (Salmo trutta L. complex) diversity in the Italian region. A multilocus Bayesian approach
submitted by brejsdi 18 minutes ago - Topic: Biology
Mediterranean trout populations display a diversity of phenotypes, representing a valuable model for the study of adaptation and a puzzling dilemma for taxonomists and biogeographers, which is further entangled by the widespread introgression of allochthonous genes. In this paper we analysed DNA polymorphism at multiple loci (sequence variation of the mitochondrial control region and eight nucl...



Multilocus assessment of phylogenetic relationships in Alytes (Anura, Alytidae)
submitted by brejsdi 19 minutes ago - Topic: Biology
With the advent of large multilocus datasets, molecular systematics is experiencing very rapid progress, but important challenges remain regarding data analysis and interpretation. Midwife toads (genus Alytes) exemplify two of the most widespread problems for accurate phylogenetic reconstruction: discerning the causes of discordance between gene trees, and resolving short internodes produced du...

Molecular phylogenetic investigations of the relationships of the echinoderm-parasite family Eulimidae within Hypsogastropoda (Mollusca)
submitted by brejsdi 19 minutes ago - Topic: Biology
The gastropod family Eulimidae has attracted considerable attention as one of the most diverse groups of parasitic molluscs in terms of number of species and ranges of body plans and parasitic strategies. However, the phylogenetic position of the family has not been established within the Hypsogastropoda and this has hampered the inference of ancestral states in the evolution of the morphology ...


Classification of the cormorants of the world
submitted by brejsdi 19 minutes ago - Topic: Biology
Relationships among the 40 or so extant species of cormorants (family Phalacrocoracidae) have been obscured by their morphological similarities, many of which have recently been shown to be the result of convergent evolution. Previous attempts to derive an evolutionarily justifiable classification for this group of birds using osteological and behavioral data have been hampered by these similar...

Gorgonia mariae and Antillogorgia bipinnata populations inferred from compensatory base change analysis of the internal transcribed spacer 2
submitted by brejsdi 19 minutes ago - Topic: Biology
The systematics within some families of octocorals (Class Anthozoa: Sub-class Octocorallia) remains uncertain in terms of morphological variability and unresolved molecular phylogenies. Elucidating the phylogenetic relationships among octocorals can help for understanding the origin of its huge biodiversity and optimizing conservation plans. The phylogenetic relationships within Gorgoniidae fam...


Cytonuclear discordance and historical demography of two brown frogs, Rana tagoi and R. sakuraii (Amphibia: Ranidae)
submitted by brejsdi 19 minutes ago - Topic: Biology
Prior studies of mitochondrial genomic variation reveal that the Japanese brown frog Rana tagoi comprises a complex of cryptic species lineages, and that R. sakuraii arose from within this complex. Neither species forms a monophyletic group on the mitochondrial haplotype tree, precluding a simple explanation for the evolutionary origins of R. sakuraii. We present a more complete sampling of mit...

A hybrid phylogenetic–phylogenomic approach for species tree estimation in African Agama lizards with applications to biogeography, character evolution, and diversification
submitted by brejsdi 19 minutes ago - Topic: Biology
Africa is renowned for its biodiversity and endemicity, yet little is known about the factors shaping them across the continent. African Agama lizards (45 species) have a pan-continental distribution, making them an ideal model for investigating biogeography. Many species have evolved conspicuous sexually dimorphic traits, including extravagant breeding coloration in adult males, large adult ma...


Molecular phylogeny of short-tailed opossums (Didelphidae: Monodelphis): Taxonomic implications and tests of evolutionary hypotheses
submitted by brejsdi 19 minutes ago - Topic: Biology
Short-tailed opossums (genus Monodelphis) represent one of the most speciose clades of New World marsupials, with 26 currently recognized species that collectively range from eastern Panama to northern Argentina. Here we present the first phylogenetic analyses of the genus based on dense taxonomic sampling and multiple genes. From most sampled species we obtained >4800bp of DNA sequence ...

How many genera and species of woolly monkeys (Atelidae, Platyrrhine, Primates) are there? The first molecular analysis of Lagothrix flavicauda, an endemic Peruvian primate species
submitted by brejsdi 19 minutes ago - Topic: Biology
We sequenced COI and COII mitochondrial genes of 141 Neotropical woolly monkeys to provide new insights concerning their phylogeography and phylogenetic relationships. For the first time, eight individuals of the endemic and extremely rare Peruvian yellow-tailed woolly monkey (flavicauda) were sequenced at these genes and compared with other Lagothrix taxa (poeppigii, lagotricha, lugens and can...

Towards a mitogenomic phylogeny of Lepidoptera
submitted by brejsdi 20 minutes ago - Topic: Biology
The backbone phylogeny of Lepidoptera remains unresolved, despite strenuous recent morphological and molecular efforts. Molecular studies have focused on nuclear protein coding genes, sometimes adding a single mitochondrial gene. Recent advances in sequencing technology have, however, made acquisition of entire mitochondrial genomes both practical and economically viable. Prior phylogenetic stu...

Hide and vanish: Data sets where the most parsimonious tree is known but hard to find, and their implications for tree search methods
submitted by brejsdi 20 minutes ago - Topic: Biology
Three different types of data sets, for which the uniquely most parsimonious tree can be known exactly but is hard to find with heuristic tree search methods, are studied. Tree searches are complicated more by the shape of the tree landscape (i.e. the distribution of homoplasy on different trees) than by the sheer abundance of homoplasy or character conflict. Data sets of Type 1 are those const...